Transcript OER PPT

ARGENTINA
AUSTRALIA
BELGIUM
BOTSWANA
BRAZIL
CAMBODIA
CANADA
CHILE
CHINA
COLUMBIA
CZECH REPUBLIC
DENMARK
DOMINICAN REPUBLIC
EGYPT
ESTONIA
FINLAND
FRANCE
GERMANY
HAITI
HONG KONG
HUNGARY
ICELAND
IRELAND
ISRAEL
ITALY
JAPAN
NIH Supports
Biomedical and Behavioral
Research Around the Globe
Including Scientists at Institutions
in over 90 Countries!
KENYA
LEBANON
MALAWI
MEXICO
NETHERLANDS
NEW ZEALAND
NIGERIA
PAKISTAN
PERU
POLAND
RUSSIA
SENEGAL
SINGAPORE
SOUTH AFRICA
SPAIN
SWEDEN
SWITZERLAND
THAILAND
TURKEY
UNITED KINGDOM
URAGUAY
ZIMBABWE
AND MORE…
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U.S. Dept. of Health & Human Services
Secretary of
Health and
Human Services
Administration for
Children and Families
(ACF)
Administration on
Aging
(AoA)
Food and Drug
Administration
(FDA)
Health Resources
and Services
Administration
(HRSA)
Center for Medicare
& Medicaid
Services
(CMS)
Agency for
Healthcare Research
and Quality
(AHRQ)
Indian Health
Services
(IHS)
National Institutes
of Health
(NIH)
Centers for
Disease Control
and Prevention
(CDC)
Agency for Toxic
Substances and
Disease Registry
(ATSDR)
Substance Abuse and
Mental Health Services
Administration
(SAMHSA)
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National Institutes of Health
Office of
Extramural Research
Office of the Director
National Institute
on Aging
National Institute
on Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
National Institute
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Eye
Institute
National Institute
of General
Medical Sciences
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing Research
National Center on
Minority Health
and Health
Disparities
National Center
for Complementary
and Alternative
Medicine
Fogarty
International
Center
National Center
for Research
Resources
NIH
Clinical Center
Center
for Information
Technology
National Library
of Medicine
Center
for Scientific
Review
National Institute
of Biomedical
Imaging and
Bioengineering
No funding
authority3
The NIH Extramural Team
The Research Partnership
Applicant
Institution
NIH
Review
Administrator
Program
Administrator
Grants
Management
Administrator
Principal
Investigator
Authorized
Institutional
Official
Sponsored
Research
Administrator
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NIH Initiatives and Hot Topics
• NIH Themes
• The B Word: NIH Budget and
the impact of ARRA
• Focus on New Investigators
• Directions for Peer Review
• Stem Cell Research
• Assuring Objectivity in Research
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Looking to the Future with the
New NIH Director
To better understand the direction of NIH, here’s some
known (and little known) facts about the leader of NIH:
1. NIH Director as of August 17, 2009
2. Former Director of the National Human Genome
Research Institute, NIH
3. Leader of the Human Genome Project
Francis S. Collins,
Ph.D., MD
4. Dr. Collins’ own lab discovered a number of important
genes, including those responsible for cystic fibrosis,
neurofibromatosis, Huntington's disease and more.
5. New York Times best selling book author
6. Interest in the interface of science and faith.
7. Musician and Rock Star of Science
8. Believes the value of the NIH community is one where
hard work, laughter, and compassion allow the
imagination to soar.
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Opportunity 1: Using high throughput technologies to understand
fundamental biology, and to uncover the causes of specific diseases
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Opportunity 1: Using high throughput technologies to understand
fundamental biology, and to uncover the causes of specific diseases
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NextGen DNA sequencing and beyond
Nanotechnology
Small molecule screening
New imaging modalities
Emphasis on comprehensive approaches
– All of the genes, all of the proteins, all of the common
variations, all of the pathways for signal transduction, all of
the patterns of gene expression, all of the steps in early
development, all of the components of the immune
system…
• Computational biology is critical
• Examples that are ripe for expanded effort
– Cancer
– Autism
– Microbiome
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– Many more….
Opportunity #2: Translating basic science discoveries into new
and better treatments
Basic Research
Drugs
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Opportunity #2: Translating basic science discoveries into new
and better treatments
• Stage is set for NIH to play a greatly expanded role in
translation
– New discoveries about the fundamental basis of disease
– Resources empowering academic investigators to
develop lead compounds and “de-risk” projects
– Opportunity for public-private partnerships
• Stem cells (including hESC and iPSC)
– Explosion of new information likely with new NIH policy
– 64 cell lines now approved for federal funding
– Therapeutic uses still uncertain but urgent to pursue
• Small molecules
– Roadmap provides high throughput screening (HTS)
capabilities that now match that of many pharmaceutical
companies
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– More on this theme later in the talk
Opportunity #3: Putting science to work for the benefit of
health care
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Opportunity #3: Putting science to work for the benefit of
health care
• Comparative effectiveness research
• Prevention and personalized medicine
– Behavioral research
• Health disparities research
• Pharmacogenomics
• Large scale prospective studies
– National Children’s Study
– Study of adult onset diseases?
• Health IT
• Health research economics
– Going beyond clinical trials to studying health care
delivery in the real world?
– What payment incentives actually work to reduce
costs and improve outcomes?”
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