Transcript Document

Chapters 8 & 18:
Metabolism and Movement of Lipids
What types of fats are needed for cell function?
Where are each of these types of fats manufactured?
How do phospholipids in the outer leaflet of the plasma membrane
get there?
How do lipids move from place to place in the cell?
Where is cholesterol made?
What are lipoproteins?
How is lipid metabolism regulated?
How does imbalance in lipid metabolism contribute to
atherosclerosis, heart attacks, and strokes?
What types of fats are needed for cell function?
Fatty Acid Synthesis and Transport
Acetyl coA carboxylase
Acetyl CoA carboxylase catalyzes the reaction:
acetyl CoA + HCO3- + ATP -> malonyl CoA + ADP + Pi
Six molecules of malonyl CoA and one molecule of acetyl CoA then interact
sequentially with fatty acid synthase to yield the final product, palmitate.
Gene Name
Common Name
Other Names
(species)
Expression
FABP1
Liver
L-FABP
h-FABP
Z protein
liver, intestine, kidney, lung(est)
FABP2
Intestinal
I-FABP
gFABP
intestine
FABP3
Heart/Muscle
H-FABP
M-FABP
MDGI
c-FABP
heart, mammary, skeletal muscle
FABP4
Adipocyte
ALBP
aP2
A-FABP
p422
p15
adipose, macrophage
FABP5
Epidermal
KLBP (murine)
mal-1 (murine)
E-FABP (human)
PA-FABP (human)
C-FABP (rat)
S-FABP (rat)
LE-LBP (rat)
DA11 (rat)
LP2 (bovine)
Melanogenic Inhibitor
abnormal skin, lens, adipose,
endothelial cells, lung,
mammary,
brain, stomach, tongue,
stomach,
placenta, heart, skeletal
muscle, intestine, testis,
retina
FABP6
Ileal
IlLBP
ILBP
BABP
IL-FABP
I15P
Gastrotropin
ileum
Gene Name
Common Name
Other Names
(species)
Expression
FABP7
Brain
B-FABP
BLBP
MRG
R-FABP (chicken)
brain, olfactory bulb
FABP(9)
Testis
T-FABP
TLBP
PERF15
testis
MP2
Myelin P2
Myelin P2
PMP2
MLBP
My-FABP
Schwann cells
ER
cytosol
ER