Transcript IntelSim - The Quilt

Enabling Research with Infrastructure:
From Alzheimer’s to Tinnitus to Big Bird
Ardoth Hassler
Associate Vice President
University Information Services
With Collaborators:
Steve Moore, Director Research Technologies
Scott Allen, Director Network Services
Clay Shields, Professor, Computer Science
Slide 1
Slide 1
Overview
• CC-NIE – Network Infrastructure: Enabling Big-Data
Science Collaboration at Georgetown
• CC*IIE – NWIRED - Network Innovation for Research
and Education at Georgetown: Science DMZ and Cloud
Services
• CC*DNI – Engineer: CRaNE – Cyberinfrastructure
Research Network Engineer (pending)
Scientific Research – Over 22 use cases from researchers from both Main
Campus and the Medical Center were cited in these proposals.
Slide 2
CC-NIE Award:
Network Infrastructure: Enabling Big-Data Science Collaboration
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Georgetown upgraded high-end networking across Hilltop campuses
Improvements enabled end-to-end 10 Gbps connectivity among GU's
science buildings, campus backbone, off-campus data center, Mid-Atlantic
Crossroads (MAX) Gigapop, and Internet2.
1Gbps or 10Gbps connections were provided to select departmental
locations including:
Programs
• Biology
• Chemistry
• Computer
Science
• Medicine
• Neuroscience
• Pharmacology
• Physics
Centers
• Center for Brain Plasticity
• Center for Functional and Molecular Imaging
• Georgetown-Howard Center for Clinical and
Translational Science
• Innovation Center for Biomedical Informatics
• Lombardi Cancer Center Shared Resources
• Universal Protein Resource
• Others
Slide 3
Enhanced Research
Infrastructure
Slide 4
CC*IIE: Create Science a DMZ
NWIRED - Network Innovation for Research and Education at
Georgetown: Science DMZ and Cloud Services
• Goals/Plans:
– Provide a friction-free, high-speed network for Big
Science and Big Data
– Create a network for scientific collaboration internally
and with external researchers
– Leverage GU's extant plan for Multi-Processing Label
Switching deployment on campus
Slide 5
CC*IIE: Create Science a DMZ
Science DMZ:
• Creates “Friction Free” IP networks on and off campus
• Leverages GU’s10Gbps network enhancements on
campus and to Internet2 (via CAAREN)
• Securely extends the network into cloud services via
encrypted Layer-2/3 connection at GU’s Virginia Data
Center (VDC)
• Benefits Access to:
– HPC and Storage at GU’s at Laurel Data Center (LDC)
– Services at VDC including access to Amazon Web
Services, Internet2 Net+, and compute and storage
resources at National Labs, XSEDE, et al
Slide 6
GU’s Science DMZ
Slide 7
R Alzheimer’s Research
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GU’s 10 Gbps network
upgrade allowed Dr.
Federoff’s team the
ability to store,
manage, and analyze
over 16 TBs of data
from blood tests from
525 participants, age
70, over a 5-year
observational period
using and validating 10
plasma phospholipid
biomarkers.
The results identified a
potential blood test for
cognitive decline that
is now moving to
commercialization.
Slide 8
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Georgetown and Howard universities received notification
of a $27 million Clinical and Translational Science Award
(CTSA) from the NIH.
The Georgetown-Howard Universities Center for Clinical and Translational Science
(GHUCCTS) is a multi-institutional consortium of medical research institutions forged from a
desire to promote clinical research and translational science. The members of the GHUCCTS
consortium are: Georgetown University (GU), Howard University (HU), MedStar Health
Research Institute (MHRI), Oak Ridge National Laboratory (ORNL), and the Washington
Veteran’s Affairs Medical Center (VAMC).
Through multiple partnerships and collaborations among the member institutions, GHUCCTS
is transforming clinical research and translational science in order to bring new scientific
advances to health care. - See more at: http://georgetownhowardctsa.org/aboutus#sthash.IY5n8cRL.dpuf
Slide 9
Next
Access to High-Scale Research Data - CTSA
Governance
Federation
Workflows
Compliance
Now
• Patient engagement
Research Network
Available Patients’ Records:
3.4 Million
• Common IRB
• BAA & DUA
• Dashboard
Pre-CTSA
No Access
GU
MedStar
HUH
VA DC
•EHR
•LAB
•Registries
•Research
•EHR
•LAB
•Registries
•Research
•EHR
•Lab
•No Std.
•Project
based
•EHR
• Cohort
Discovery
• BI Services
• i2b2
GU
MedStar
HUH
VA DC
•EHR
•LAB
•Registries
•Research
•EHR
•LAB
•Registries
•Research
•Project
based
•EHR
•i2b2
•Project
based
•EHR
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•
•
SHRINE
CTSAs
Friction Free research •
•
Network
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•
•
•
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Common IRB
BAA & DUA
Dashboard
CTMS
Coalitions
Team science
Underserved Pop
• Cohort
Discovery
• BI Services
• i2b2
GU
MedStar
HUH
•EHR
•LAB
•Registries
•Research
•EHR
•LAB
•Registries
•Research
•EHR
•LAB
•Registries
•Research
VA DC
•Project
based
•EHR
Hybrid Cloud Computing solution for research
Built on UIS LDC & AWS’s Virtual Private Cloud Architecture
• Science as Service
• Elastic environment
• Storage and
computing
at scale
Isolated AWS
resources
Subnets
NAT
Router
VPN
Gateway
Internet
Secure VPN
Connection over
the Internet
GU
10 Gig
VPC
Amazon Classic
Web Services Cloud
Investigator s Desktop
10 Gig LAN
Source: Amazon Web Services VPC Architecture
Globus Genomics Project: Leveraging High
Speed Bandwidth at GU:
• Globus Genomics (GG):
ICBI and Genomics Shared Resource at
Georgetown University Medical Center
initiated a joined pilot project with the
University of Chicago. The project is
introducing and implementing high
efficiency tools and capabilities to transfer
large data sets to the cloud, and use
pipelines and software applications
developed by the Center.
– Data Management SaaS
– Next-gen sequence analysis pipelines
– Flexible, scalable, cost effective
Globus Genomics
Pilot
Current
Projects
8
Users
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Neuroscientists Discover Brain Abnormalities
for Tinnitus and Chronic Pain
GUMC and Germany’s Technische
Universität München have uncovered
the brain malady responsible for tinnitus
and for chronic pain. The scientists
describe how the neural mechanisms
that normally “gate” or control noise and
pain signals can become dysfunctional,
leading to a chronic perception of these
sensations. They traced the flow of
these signals through the brain and
showed where “circuit breakers” should
be working — but aren’t.
https://gumc.georgetown.edu/news/NeuroscientistsUncover-Brain-Abnormalities-Responsible-forTinnitus-and-Chronic-Pain
Josef Rauschecker, PhD, DSc
Slide 14
Measureable Outcomes
Center for Brain Plasticity and Recovery
454 MB Brain Image File
Before CC-NIE: 39 seconds to upload to Data Center
After CC-NIE: 19 seconds
http://cbpr.georgetown.edu/
Slide 15
Measureable Outcomes
Children’s Digital Media Center:
Understanding Digital Media’s Influence on Children
Sandra L. Calvert, Ph.D., is Professor of
Psychology at Georgetown University (G.U.)
and a co-founder and the Director of the
Children’s Digital Media Center a multiinstitution interdisciplinary research center
that has received funding primarily from four
collaborative grants from the National
Science Foundation.
Dr. Calvert’s lab is connected to the 10 GBs
campus network. She wrote:
“Just wanted to thank you for getting my office
and Center into the digital age!”
- Sandy
http://cdmc.georgetown.edu/
Slide 16
Approaches: Two Examples
• AWS
– Connected to Amazon Cloud using site-to-site VPN
– Proteomics Information Resource Center was satisfied
with test results
– More to come with Science DMZ
• Results of Prior Work for Notice for Prospective PIs
Networking Infrastructure Enhancements: Georgetown University is the recipient of NSF CC-NIE award
#1340971, Enabling Big-Data Science Collaboration at Georgetown (2013, $379,018) and CC*IIE award #1440743,
NWIRED - Network Innovation for Research and Education at Georgetown (2014, $425,373). These awards enabled
campus network infrastructure upgrades to 10 Gbps with 1 Gbps uplinks for most researchers, increased the speed of
our connection to Internet2, and enabled implementation of a Science DMZ (in progress). When completed in 2015, the
Science DMZ portion of the network will be optimized for high performance scientific applications rather than for general
purpose business systems. [Ardoth A. Hassler, PI]
Slide 17
Summary
• What’s Ahead
– BIG Data
• AvesTerra infrastructure: force migration, HIV/AIDS
– http://avesterra.georgetown.edu/
• McCourt School of Public Policy Massive Data Institute
– http://mccourt.georgetown.edu/massive-data-institute/research
– Much more…
• Computer Science Collaborations
• Neuroscience is GU’s most externally funded research
• Tinnitus Research is one of many projects that will benefit from a
CC*DNI award
Results of CC-NIE and CC*IIE awards
are enabling research at Georgetown
Slide 18
Questions?
Contact
• Ardoth Hassler
[email protected]
• Steve Moore
[email protected]
• Scott Allen
[email protected]
• Clay Shields
[email protected]
Slide 19