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TM A Concentrated Form of Refined Copper MicroEncapsulated Organic Acids and Essential Oils Manufactured by AGRANCO CORPORATION USA The good actions of today make for a better tomorrow AGRANCO World Distribution Network Agranco Group is a manufacturing and sales organization headquartered in Coral Gables, Florida and manufacturing companies located in Mexico and the U.S. It has a network of distributors in Mexico, United States, Central America, South America, Europe, Middle East, Africa and Asia, all dedicated to providing distribution and service of our products, with its own staff of engineers, technical specialists and PhD in every area of activity. Animal Nutrition: Selective Adsorbents Mycotoxins, Organic Minerals microencapsulated probiotics and Immunomodulators, Enzymes, Yeast and Microflora regulators. Agricultural Industry: Organic Insecticides, Fertilizers, natural and biodegradable. Aquaculture Industry: Yeast, Enzymes, Probiotics and oligosaccharides for shrimp and fish rations. Food Processing : Disinfectants food for human consumption. Sugar Industry : Stabilizers of pure cane juice Water Treatment : Decomposers of organic matter and water purification. The products are marketed under its own brand, are unique and specific to improving processes in each industry, having fully researched about them, proving their effectiveness in every field. We invite you to evaluate waiting to exceed your expectations and be part of our user list. AGRANCO Distributors Worldwide Central Offices Distribuidores AGRANCO About Copper and Agracopper Diarrhea Control, Immunity Modulation, and Antibiotics Reduction - Typically, for this purpose the diets contain zinc oxide and/or copper sulphate as sources for inorganic minerals. - They are added in great quantities because they re-combine and about 75% to 95% is lost in the digestive tract, by excreting to the outside, losing and creating contamination and bad odor in the environment. - Its use also occupies much space in the formula. - This also affects acidity on the stomach of the monogastrics. The Reason to Microencapsulate the Cooper Sulphate (Agracooper) - The metabolism and Cu’s absortion is affected by Molybdenum,Sulfur, Calcium, Iron, Manganesium, Zinc, Cobalt, Lead, Cadmium and Selenium. - Formation of unavailable molybdates, which are generated in the stomach/ proventriculus due to the interaction between molybdenum with copper and sulfur, reduce the availability of Cu due to its transformation into copper sulfure (J. Benitez 2011). - With the use of aa synthetic, the absortion of CU can become depressed (D. Mahan, et. al., 2010). - Agracopper, while being 100% protected, does not suffer loses by interactions with other minerals and the synthetic aa in diets. Certified Quality There is currently a tremendous amount of research going into antimicrobial effects of copper. It is believed that copper has the ability to kill harmful bacteria through a multi-faceted approach. The thought is that contact of the bacterium with the surface damages the cell membrane, or outer envelope of the cell by several mechanisms. This makes the bacterium “leaky” as it loses water and with it, many soluble essential nutrients and salts. Furthermore, copper ions released from the surface can enter the cell uninhibitedly and by this action will help to enhance the effect of AGP used in the Feed. In addition, this supports our innovative concept of Agracopper which protects the copper sulfate from forming complexes with other minerals in the feed and dissociation in the Stomach. The multi-target effect of Agracopper makes resistance extremely unlikely as copper ion kills bacteria very quickly and leaves almost no survivors. This is due to the fact that there is neither the time for bacteria to “learn” how to resist copper or the possibility to pass on any knowledge to a significant population of survivors. Copper remains essential to bacteria and bacterial resistance is typically observed against non-essential components such as many of the antibiotic growth promoters in animal Feed. Resistance to copper ion, which is recognized by the cell as a needed nutrient, is extremely unlikely. Finally , we are very confident that Agracopper in poultry feed will act to potentiate the effectiveness of AGP , to further increase gut health and lower the incidence of Necrotic Enteritis. Certified Quality Cooper Sulphate vs. Agracopper - Frequently copper sulphate is included as a promoter of growth or fungicide because it is very economical, applying 500 grams of copper sulphate (125 g of copper) by metric ton MT. In case of severe infections caused by fungus, you get to use 1 kilogram of copper sulphate (250 g of cooper) by MT. - It is reported that levels of 250 ppm of Cu, already can cause poisoning in poultry and the presence of gizzard’s erosion. (M. Contreras y D. Zaviezo). - Gizzard’s erosion (GE)..…can be caused by presence of micotoxins in the feed, polisaturated acids, high levels of cooper, diets defficient in Vitamin K and defficiency in methionine, among others. - Jensen et al.(1991) induced oral lesions in poultry while supplementing copper sulphite in diets. Incidence and severity of the oral lesions showed a linear increase as the cooper sulphate’s concentrations were increased. Severity of GE also increased with the concentration of cooper sulphate. - Vitamins are by far the most labile nutrients since they are harmed at a great or low degree by a variety of factors, such as: Heat, Light, Oxigen, Acids, Alcaloids, Reducing Agents, Oxidating Agents, metallic agents, etc. - Vitamin B1 is unstable to pH neutral and alcaline pH, catalyzed by metallic ions such as cooper and totally destroyed by sulphites… vitamin C is the most sensitive of vitamins, it is labile in presence of metallic ions specially cooper (J. King y S. de Pablo, 1987). Selecting the Source of Cooper Sulphite - When cooper sulphite is used, it is extremely important to select a good source which does not cause lumps, thus avoiding mistakes upon weighing and blending which can provoke an excessive ingestion. Precautions: - A good quality product (free of dyoxine and heavy metals). - Concentration (Pentahydrated: Cu 25.4 and S12.8 (+/- 6)) - Free from lumps (Not matted down), exact weighing and perfect blend. Liver Pancreas Esophagus Ceum Rectum Stomach Duodenum Small Colon Digestibility intestine Pathogens The lipid matrix protects it upon passing through the stomach and slowly releases it, through the extension of the small intestine and other elements which really affect the traditional cooper sulphate. This allows the effect of copper sulphate to take place throughout the small and large intestine, and upon being slowly released, it has a maximum effect in the intestinal microflora. Agracopper virtually is not excreted to the outside, thus reducing contamination of the environment. It does not affect acidity of the digestive tract on monogastrics. pH Certified Quality (jejunum, ileum) Certified Quality Agracopper Since it is microencapsulated in a lipid matrix, palatibility problems are eliminated. More effective in the control of diarrhea by reducing the need for antibiotics and growth promoters. Its effect is complete along the entire small and large intestine. Antibacterial effect of Agracopper A high level of inclusion of Zn and Cu diminshes the activity of pathogens bacteria. (Ole Hojberg et al, 2005). Bivalent cations of Zn ion (Zn ++) and Cu (Cu ++) seem to have an affinity with the linking sites of E. coli. Zn ion and Cu, preferably link to glycoprotein and to glycolipid of the intestinal wall, which present negative charges. E. coli cannot find any union site to adhere, penetrate and generate toxicity in the tissue in question. For this purpose the zinc/cooper ion shall be easily released at the proper time and place. How Does Agracopper Work in the TGI? Antiviral Effect and Excessive Immune Response of Agracopper The Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved in the process of adhesion to other cells or the extracellular matrix in a process called "cell adhesion". Cu ions get to block the joints between the Virus and the cell membrane’s CAMs, thus reducing the infection of epithelial cells in the intestine. On the other hand, once the ions adhere to CAMs, they can also block the joints between them and the immune cells that cause inflammation, regulating the flow of these cells to the intestinal epithelium thus preventing allergies due to excessive immune responses. Virus capsid CAMs of the host cells. Agracopper Copper Sulphate 70% Copper Sulphate Micro-Encapsulated Product Data Sheet Premix for Use in Animal Feed Composition 100% By-Pass action in the stomach. Prevents interaction with HCL present in the stomach. For every 100gr. content: Active Material: Copper Sulphate 70% Coating Material: Hydrogenated Vegetable Oil Progressive liberation of copper due to the degradation of the vegetable matrix by pancreatic lipase. Characteristics Agracopper is a micro encapsulated Copper Sulphate supplement. The micro encapsulation ensures a more effective release of copper in the gastro intestinal tract of the animal. Copper Sulphide, the principal component in Agracopper contributes to improved production performance and prevention of diarrhea in piglets Mode of Action Due to the progressive liberation of free copper ions in the intestine where it’s needed, the copper effect is improved dramatically. The lipids of vegetable origin that form the coating Agracopper are degraded by pancreatic of lipase when the product reaches the duodenum. Subsequently the copper is slowly liberated in the small intestine. In this way, the distal part of the small intestine becomes the place for obtaining micro flora modulating effect. The continous liberation of free copper ions accomplishing the better control of harmful bacteria. Agracopper Copper Sulphate 70% Properties Product Properties: Appearance: Granular, free flowing powder Color: Light Blue Odor: Characteristic, Slightly sweet fatty acid Physical Properties: Moisture: <3% Particle Size: Uss 20(850u) .05% Max Temperature of maximum 90-95 C° when coating is melting Additional Information Presentation: Polyethelene bags in 20kg boxes or 50kg drums. Storage: Store in dry place, ambient moderate temperatures, in closed packaging when product is not being utilized. Shelf Life: Best before 12 months from date of manufacturing. GMO: All the ingredients used in the manufacturing of Agracopper is Non-GMO Doses according to species Swine: Weaning piglets 25-80 g/MT of complete feed. Other pigs 300 g/MT Layers, Broilers, & Turkeys: 50-100 g/MT of complete feed. Dairy Cattle: 12g of Agracopper per head, per day. All ingredients approved by FDA under the American Association of Feed Control Officials under Official AAFCO N° 57.150. Publication: 1,998 Country of Origin USA Manufacturer and Worldwide Distributor AGRANCO CORP. USA 2655 South Le Jeune Rd. Suite 805, Coral Gables, FL. 33134 Tel (305) 856 3782 Fax (305) 856 3734 E mail: [email protected]