Transcript Pharmacology Tutoring for Antidepressants

PHARMACOLOGY
TUTORING FOR
ANTIDEPRESSANTS
By Alaina Darby
Stella is feeling sad, hopeless, and guilty and has persistent headaches,
fatigue and insomnia. With no additional symptoms, which of the following
classes of depression would this fall into?
•
a.
b.
c.
d.
Reactive
Major depressive disorder
Bipolar disorder
Post-partum
•
Which of the following is most responsive to antidepressant drugs and ECT?
Reactive
b. Major depressive disorder
c. Bipolar disorder
d. Post-partum
a.
•
What is the biogenic amine hypothesis for depression?
Deficit of norepinephrine and serotonin
b. Deficit of dopamine and serotonin
c. Excess of norepinephrine and serotonin
d. Excess of dopamine and serotonin
a.
Which of the following is not an adaptive change that could underlie the
therapeutic lag of antidepressive treatment?
•
Beta-receptors
b. cAMP and serotonergic neurotransmission
c. Norepinephrine receptor uncoupling
d. Neurogenesis
a.
Which of the following is an issue with using St. John’s Wort to treat
depression?
•
It is much less effective than the placebo at treating depression
b. It interferes with various medications
c. It is not available in the US
d. It has similar efficacy to SSRI’s
a.
•
Which of the following can cause resistance to antidepressants?
Downregulation in norepinephrine receptors
b. Downregulation in serotonin receptors
c. Single nucleotide polymorphisms in MDR1
d. Single nucleotide polymorphisms in norepinephrine receptors
a.
•
Which of the following is derived from amitriptyline through metabolism?
Doxepin
b. Nortriptyline
c. Trimipramine
d. Desipramine
a.
Sally has just started taking an antidepressant. She is experiencing
drowsiness, dysphoria, anxiety, and impaired cognition. Which of the
following is she most likely taking?
•
a.
b.
c.
d.
Duloxetine
Clomipramine
Paroxetine
Tranylcypromine
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Which of the following is not an adverse effect of tricyclic antidepressants?
Hypertension
b. Sedation
c. Weight gain
d. Sexual disturbances
a.
•
Which of the following should not be taken with clonidine?
Duloxetine
b. Clomipramine
c. Paroxetine
d. Tranylcypromine
a.
Which of the following is a norepinephrine transport inhibitor that can also
be used as an antipsychotic?
•
Trazodone
b. Vilazodone
c. Amoxapine
d. Maprotiline
a.
Which of the following is most similar to vilazodone in its mechanism of
action?
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Duloxetine
b. Venlafaxine
c. Bupropion
d. Vortioxetine
a.
Molly needs to lose weight. Which of the following would be least likely to
be prescribed for her depression?
•
Bupropion
b. Duloxetine
c. Trazodone
d. Mirtazapine
a.
Which of the following has a main MOA that does not block
neurotransmitter transporters?
•
Bupropion
b. Duloxetine
c. Trazodone
d. Mirtazapine
a.
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Which of the following can also be used to aid in smoking cessation?
Bupropion
b. Duloxetine
c. Trazodone
d. Mirtazapine
a.
Which of the following might be prescribed to someone who needs to be
alert in his job and has low blood pressure?
•
Venlafaxine
b. Duloxetine
c. Mirtazepine
d. Amitriptyline
a.
Which of the following might be considered first line therapy in a patient
with major depression?
•
Amoxapine
b. Trazodone
c. Citalopram
d. Tranylcypromine
a.
Which of the following would be least likely to be considered in a patient
with major depression?
•
Amoxapine
b. Trazodone
c. Citalopram
d. Tranylcypromine
a.
•
Which of the following can be administered for weekly administration?
Citalopram
b. Fluoxetine
c. Paroxetine
d. Fluvoxamine
a.
Katie just switched from tranylcypromine to paroxetine for her depression
and has begun to exibit signs of hyperpyrexia, hyperreflexia, tremor, shivering,
and seizures. What is the reason for these symptoms?
•
a.
b.
c.
d.
Understimulation of 5-HT1A receptors
Overstimulation of 5-HT1A receptors
Downregulation of 5-HT1A receptors
Upregulation of 5-HT1A receptors
•
What action should immediately be taken to treat Katie?
Antiparkinson’s drug (benzamine) for her tremors
b. Discontinue paroxetine
c. Supportive therapy
d. Anticonvulsant (phenytoin) for her seizures
a.
•
Which of the following is not metabolized by MAO-B?
Norepinephrine
b. Serotonin
c. Tyramine
d. Dopamine
a.
•
Which of the following could be taken with MAOI’s?
Pseudoephedrine
b. Dextromethorphan
c. Fluoxetine
d. Lithium
a.
•
Which is not true of lithium?
Its activity is thought to occur through inhibition of inositol phosphate
signaling
b. Its therapeutic window is very narrow
c. It is a potent blocker of the Na/K-ATPase pump
d. It is extensively metabolized
a.
•
Which of the following would be safe to take with lithium?
Aspirin
b. Furosemide
c. Carbemazepine
d. Hydrochlorithiazide
a.
Sandra has bipolar disorder and is taking birth control. Which of the
following drugs/drug combinations would be not be suitable for her?
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Lithium
b. Valproic acid
c. Carbamazepine
d. Antipsychotic/antidepressant combination
a.
Which would not be a reason to choose valproate or carbamazepine over
lithium to treat bipolar disorder?
•
Ability to increase the dose faster
b. Quicker response
c. Risk of pregnancy
d. Better therapeutic index
a.