Transcript ACUTE RENAL FAILURE

ACUTE RENAL FAILURE
• Kidneys are the pair organs located in the retroperitoneum
(at the level of 12-th rib in the loin region). Their main
function is elimination of the metabolic waists from the
organism. They are supplied with blood by paired renal
arteries, which are direct arterial branches of abdominal
aorta.
• Nephron is the basic functional unit of the kidneys. Its
structure is quite complicated: it consists of renal corpuscle
(Bowman-Shumlanski’s capsule and glomerulus),
proximal convoluted tubule, loop of Henle, distal
convoluted tubule and direct tubule.
•
• Kidneys are exclusively “hard-working” organ. Their total
weigh is hardly 0,4% of the total body weight, however
they receive 25 % of cardiac output. 10% of total inhaled
oxygen are used for their metabolic needs. During the day
nearly 150 liters of primary urine are ultrafiltrated out of
the blood. Ultrafiltration is possible only when effective
filtration pressure is not less than 12 mm Hg. It is defined
as a difference between hydrostatic (47 mm Hg), oncotic
(25 mm Hg) and intracapsular pressure (10 mm Hg).
• EFP=Hp(47)-Op(25)-ICp(10)= 12 mm Hg
• So when hydrostatic pressure (mean arterial pressure) is
decreasing or when intracapsular pressure is reaching
critical values filtration stops and renal failure appears.
• In tubules water, electrolytes and glucose are reabsorbed and metabolic
wastes are secreted to the urine. Eventually during one day only 1 % of
primary urine is evacuated from the organism in the form of secondary
urine with high concentration of toxic substances.
• Kidneys participate in haematopoiesis, regulation of fluid balance,
electrolytes metabolism and acid-base balance.
• Kidneys are also organs of secretion: their parenchyma produces
rennin – substance very important for vascular tone regulation.
• 6.2 Etiology and pathogenesis of acute renal failure (acute kidney
injury).
• Acute kidney injury is a syndrome appearing due to sudden and
progressive affection of nephrones, which causes violation of renal
function and induces life-threatening homoeostasis disorders.
• The reasons of acute kidney injury are divided into 3 gorups:
• 1. Prerenal: pathological conditions, which lower renal blood flow,
such as hypovolemia, hypotension, thrombosis, renal artery embolism,
renal artery spasm, haemolysis, myolysis (muscle desintegration). Thus
the prerenal failure can be connected with the massive blood loss,
shock (traumatic, anaphylactic, cardiac), dehydration (burns,
pancreatitis, peritonitis, vomiting, diarrhoea), crush-syndrome,
transfusion of incompatible blood, acute respiratory failure.
• 2. Intrinsic: the primary damage is caused to the renal parenchyma
by exogenous toxins (alcohol surrogates, acetic acid, ethylene glycol,
heavy metal salts), nephrotoxic antibiotics (aminoglycosides), bacterial
toxins (in case of sepsis), acute glomerulonephritis, eclampsia.
• 3. Postrenal: acute renal failure appears due to
complications of urine outflow (tumours and calculi of
renal pelvis and ureter, prostate, accidental ligation of the
ureters during operation).
• In 70% of the cases acute renal injury appears as a result of
prerenal cause. In stress conditions (massive blood loss,
multiple injuries) adrenals intensively produce
catecholamines: arterioles of skin, smooth muscles,
intestines and kidneys spasm. As you probably remember
this helps to save the brain and heart (additional blood for
circulating blood volume), however for the rest organs this
situation, lasting over 3-4 hours will bring ischemia and
even necrosis.
• Another mechanism for acute renal failure is connected
with the acute vascular insufficiency (collapse,
endotoxicosis). Hydrostatic pressure decreases and thus
filtration of the blood lowers.
• The mechanism of this pathological process is next:
hypoperfusion-renal ischemia-hypoxia-coagulation of
blood in glomerular vessels-termination of plasma
filtration-affection of tubules membranes- compression of
the nephron and capillaries-renal necrosis.
• Death of over 75% of nephrons finds its clinical
manifestation in acute kidneys injury. All the functions of
the kidneys- ultrafiltration, reabsorption, secretion,
bioactive substances production – are violated.
• Clinically in acute kidneys injury we differentiate 5 stages:
• I. First stage (initial) is the stage of shock: depends on the initial
aggressive agent and duration of its influence. It can last several hours
or several days (2-3). Clinic also depends on the causing factor,
however first of all you should observe carefully the haemodynamics
and urine output, because correct evaluation of patient’s condition and
proper treatment may prevent the development of next stages.
• Warring symptoms are:
• arterial hypotension (systolic blood pressure less than 70 mm Hg
if it stays during few hours);
• decrease of urine output;
• hyposthenuria (low specific gravity- less than 1006-1008)
Background
• Common in Hospitalized patients
• Associated with high Morbidity and
Mortality
• Often Multifactorial
• Identifiable risk factors.
Renal biopsy
Renal biopsy on hospital day 2
demonstrating massive oxalosis
Acute dialysis
Acute Renal Failure
•
•
•
•
•
•
Sudden decrease in function (hours-days)
Often multifactorial
Pre-renal and intrinsic renal causes 70%
oliguric UOP < 400 ml
Non-oliguric (up to 65%)
Associated with high mortality and
morbidity
Acute Renal Failure
Diagnosis
• Laboratory Evaluation:
– Scr, More reliable marker of GFR
• Falsely elevated with Septra, Cimetidine
• small change reflects large change in GFR
– BUN, generally follows Scr increase
• Elevation may be independent of GFR
– Steroids, GIB, Catabolic state, hypovolemia
– BUN/Cr helpful in classifying cause of ARF
• ratio> 20:1 suggests prerenal cause
• ratio 10-15:1 suggests intrinsic renal cause
Acute Renal Failure
Diagnosis (cont’d)
• Urinalysis
– Unremarkable in pre and post renal causes
– Differentiates ATN vs. AIN. vs. AGN
• Muddy brown casts in ATN
• WBC casts in AIN
– Hansel stain for Eosinophils
Acute Renal Failure
Diagnosis (cont’d)
• Urinary Indices;
– FE Na = (U/P) Na X (P/U)CrX 100
• FENa < 1%
C/W Pre-renal state
– May be low in selected intrinsic cause
» Contrast nephropathy
» Acute GN
» Myoglobin induced ATN
• FENa> 1% C/W intrinsic cause of ARF
Prerenal Azotemia
• Nearly as common as ATN (think of as
early part of the disease spectrum)
• Diagnose by history and physical exam
– N/V, Diarrhea, Diuretic use,...
• low FENa (<1%)
• high BUN/creat ratio, normal urinary
sediment
• Treat by correction of predisposing factors
Acute Renal Failure
Etiologies
• Acute Tubular Necrosis
–
–
–
–
Most common cause of intrinsic cause of ARF
Often multifactorial
Non-oliguria carries better prognosis
Ischemic ATN:
• Hypotension, sepsis, prolonged pre-renal state
– Nephrotoxic ATN:
• Contrast, Antibiotics, Heme proteins
Acute Tubular Necrosis (ATN) -- 2
• Diagnose by history,  FENa (>2%)
• sediment with coarse granular casts, RTE cells
• Treatment is supportive care.
– Maintenance of euvolemia (with judicious use of
diuretics, IVF, as necessary)
– Avoidance of hypotension
– Avoidance of nephrotoxic medications (including
NSAIDs and ACE-I) when possible
– Dialysis, if necessary
• 80% will recover, if initial insult can be reversed.
Contrast nephropathy
• 12-24 hours post exposure, peaks in 3-5
days
• Non-oliguric, FE Na <1% !!
• RX/Prevention: 1/2 NS 1 cc/kg/hr 12 hours
pre/post
• Mucomyst 600 BID pre/post (4 doses)
• Risk Factors: CRF, Hypovolemia.
Rhabdomyolytic ARF
• Diagnose with  serum CPK (usu. >
10,000), urine dipstick (+) for blood,
without RBCs on microscopy, pigmented
granular casts
• Common after trauma (“crush injuries”),
seizures, burns, limb ischemia occasionally
after IABP or cardiopulmonary bypass
• Treatment is largely supportive care.
• Alkalinization of urine .
Acute Glomerulonephritis
• Rare in the hospitalized patient
• Most common types: acute post-infectious
GN, “crescentic” RPGN
• Diagnose by history, hematuria, RBC casts,
proteinuria (usually non-nephrotic range),
low serum complement in post-infectious
GN), RPGN often associated with antiGBM or ANCA
• Usually will need to perform renal biopsy
Acute Glomerulonephritis (2)
• If diagnosis is post-infectious, disease is
usually self-limited, and supportive care is
usually all that is necessary.
• For RPGN, may need immunosuppressive
therapy with steroids ± Cytoxan,
plasmapheresis (if assoc. with anti-GBM)
Atheroembolic ARF
• Associated with emboli of fragments of
atherosclerotic plaque from aorta and other large
arteries
• Diagnose by history, physical findings (evidence
of other embolic phenomena--CVA, ischemic
digits, “blue toe” syndrome, etc), low serum C3
and C4, peripheral eosinophilia, eosinophiluria,
rarely WBC casts
• Commonly occur after intravascular procedures or
cannulation (cardiac cath, CABG, AAA repair,
etc.)
Acute Interstitial Nephritis
– Usually drug induced
• methicillin, rifampin, NSAIDS
– Develops 3-7 days after exposure
– Fever, Rash , and eosinophilia common
– U/A reveals WBC, WBC casts, + Hansel
stain
– Often resolves spontaneously
– Steroids may be beneficial ( if Scr>2.5
mg/dl)
Acute Renal Failure
Etiologies
• Post-Renal
– Bladder outlet obstruction
• BPH, intrapelvic pathology
– Crystalluria
• Acyclovir, Indanivir, Uric Acid
– Papillary tip necrosis
• DM with pyelonephritis
• Analgesic abuse
• Sickle cell disease
Prevention
What works?
• Maintenance of euvolemia
• Avoidance of nephrotoxins when possible
– NSAIDs, aminoglycoside, Amphotericin, IV
contrast
• BP control--avoidance of excessive hypo- or
hypertension
Prevention
What doesn’t work?
• Empiric use of:
– Diuretics (i.e., Furosemide, Mannitol)
– Dopamine (or Dopamine agonists such as
Fenoldopam)
– Calcium-channel blockers
Acute Renal Failure
Treatment
•
•
•
•
•
Water and sodium restriction
Protein restriction
Potassium and phosphate restriction
Adjust medication dosages
Avoidance of further insults
– BP support
– Nephrotoxins
Hyperkalemia
• Highly Arrhythmogenic
– Usually with progressive EKG changes
• Peaked T waves ---> Widened QRS--> Sinus wave
– K> 5.5 meq/L needs evaluation/intervention
– Usually in setting of Decrease GFR but:
• medication also a common cause
– ACEI
– NSAIDS
– Septra, Heparin
Dialysis Indications
• Refractory hyperkalemia
• Metabolic acidosis
• Volume overload
• Mental status changes