Transcript 3. Wallace E, Keogh C, Smith SM, Dimitrov BD, Fahey T

Royal College of Surgeons in Ireland
Coláiste Ríoga na Máinleá in Éirinn
HRB Centre for Primary Care Research
17th Internal Meeting, 3 February 2011
10.30-12.00
RCSI, Dept. of General Practice, Beaux Lane House, Mercer St. Lower, Dublin 2
Division of Population Health Sciences
Agenda
Items
Person
1) Introduction
1.1) Review of Minutes from the 17th Internal Meeting
1.2) New Database for reporting on WPs with time schedule - responsible personnel and
deliverables
1.3) Interim Report to HRB – submitted in Jan 2011 & preparation for 22-23/3/11 meeting with
international panel
2) WP1:
2.1) Elderly & prescribing
2.1a) GPRD
2.1b) PCRS – between practice comparison
2.1c) PCRS – PPI prevalence & cost
2.1d) Cohort Study
2.1e) Opiates and Elderly
2.1f) EPES / Modelling Study
2.2) Children
2.2a) Antibiotic prescribing – Prescribing statistics study/Practice level variations
2.2b) Psychotropic medicine – Stimulants (APHD)/Benzodiazepines/Antidepressants
2.2c) GUI
2.3) Pregnant Women
2.3a) Methadone Retrospective Cohort Study
2.3b) Methadone Prospective Cohort
2.4) Methadone datasets analyses
2.4a) Scottish dataset
2.4b)Irish dataset
2.5) CSO (first linkage planned – an update)
Division of
2.6) Multimorbidity
BDD
BCo/ND
TFF/BDD
CC
RG/GC
MB
CK/KOB/NM
UR/NM/CK/KOB
UR/TOD
UR/TOD
BC/ND
Population
GC/NM
BCo
GC
Health
Sciences
TOD/SS
Agenda (cont.)
3) WP2:
3.1) Systematic Reviews in progress – update
3.2) Search Strategy Paper (In press) - update
3.3) Quality Paper – update
3.4) ICT applications
ND
CK/EW
EW/SS
4) WP3:
4.1) RCT for Clinical Decision Support System for methadone
maintenance therapy
- Paper with Liang/GC (MedInfo 2010) – accepted (In press) – to appear in 2011 (at proof
reading stage
4.2) eCPR’s (International Register application layout – update)
4.3) Quality Improvement – Health Intelligence Unit
5) Meetings
5.1) 2-nd Consortium Meeting in Spain for finalisation of the EU Project Proposal “EuropaLIVE!”
for submission with RedZinc to FP7 ICT - FIRE Call (Jan 2011) – Submitted to EU
on 18/1/11
5.2) 2011 Summer Conference - Indicators of Quality in Prescribing – suggested topics:
Quality of prescribing in the elderly
- STOPP/BEERS critera
- Appropriateness of prescribing among older people in Northern Ireland
- Opiates and the elderly
EW
BDD/GC/BC
EW/BCo
BCl
BDD/EW
TF
CC
MB
RG/GC
Division of Population Health Sciences
Agenda (cont.)
TILDA
- Prescribing of medications with no evidence of benefit - glucosamine, hyaluronic acid and
chondroitin
Quality of prescribing in children
- Indicators of quality prescribing in children
- Antibiotic prescribing and practice variation
-Prescribing of psychotropic medication in children
RG/GC/KOB/CK/
NM/CC
CK/KOB/NM
CK/KOB/NM/UR
UR/NM
5.3) AUDGPI ASM – Report
BDD/EW/CK
6) List of publications
6.1 List of peer reviewed publications (Published, submitted, revised, planned)
6.2 List of presentations (made, upcoming):
ND
ND
•SAPC 2011 – workshop with Oxford (UK) –
Deadline 11/2/11
•SSM Annual Meeting 14-16/9/11, Warwick (UK) –
Deadline 14/3/11
BDD
7) National / International Projects / Grants
7.1) Planned/awarded/started/rejected
• SafetyNet Project Proposal – an update
• FP7 ICT TRANSFoRm Project – first 6-months completed - update
• Irish Heart Foundation Project (Noel Hickey Bursary) on ABCD2 systematic review and
validation - update
• FP7 ICT EuropaLIVE! Project – submitted 18/1/11
KOB/BDD
DC/BDD/TF
RG/BDDBDD/EW
BDD/TF/EW
Division of Population Health Sciences
Agenda (cont.)
8) HRB Centre Website and WPs Progress Update Template
8.1) – Latest news, updates etc.
9) Other items (internal):
9.1) Training Assistants (Elderly Cohort Study) – update
9.5) 18th Internal Meeting in March 2011 (TBC)
ND
CC/BDD
Division of Population Health Sciences
Pregnant Women
Summary Retrospective Cohort Study:
Methadone and adverse perinatal outcomesAccepted for publication in American Journal of Obstetrics &
Gynecology.
Prospective Cohort Study:
Methadone use and pregnancy outcomes in a prospective
cohort of women –
.
Division of Population Health Sciences
Systematic reviews – update 3/2/11
•
•
•
•
•
•
A Systematic Review of the diagnostic accuracy of signs and symptoms and the
validation of the Centor score in predicting A B-haemolytic streptococcal
pharyngitis in adults in Primary Care : Submitted to BMC Family Practice
Predicting stroke in adults with non-rheumatic atrial fibrillation: A systematic
review of the validation of the CHADS2 Clinical Prediction Rule: Submitted to
Stroke
A Systematic Review and Meta-Analysis of the Alvarado Score in Predicting
Acute Appendicitis: Submitted to BMJ.
Systematic Review and meta-analysis on diagnostic accuracy of signs &
symptoms predicting uncomplicated urinary tract infection in women: Published,
BMC Family Practice
Botulium Toxin Injection in the treatment of Lateral Epicondylitis – a
systematic review:
Rejected by the British Journal of Sports Medicine, September 2010, in preparation for
BMC Musculoskeletal Disorders
Prognostic value of the ABCD2 clinical prediction rule – a systematic review &
meta analysis:
Accepted by Family Practice following revisions.
Predicting hospital admission in community dwelling adults: The Pra review
needs to be finished regarding methodology.
Division of Population Health Sciences
List of Publications 2010-11
In preparation:
1.
Dimitrov BD, Motterlini N, Bennett K, Stevens R, Fahey T. A new, “derivation study” method to
assess the predictive ability of clinical prediction rules in a meta-analysis of validation studies.
2.
Galvin R, Fahey T. Clinical Prediction Rules: what they mean in the context of physiotherapy
practice. Planned date for submission, January 2011.
3.
Keogh C, Reulbach U, Motterlini N, Bennett K, Fahey T. Antibiotic prescribing in Irish children
receiving free medical care.
4.
Wallace E, Smith SM, Dimitrov BD, Fahey T. Methodological quality assessment of Clinical
prediction rules relevant to primary care-a review.
5.
Wallace E, Smith SM and the IDAP group. The IDAP framework for impact analysis of Clinical
prediction rules. In preparation. Planned date for submission. Planned date for submission, February
2011.
Division of Population Health Sciences
List of Publications 2010-11 (cont.)
8.
Wallace E, Keogh C, Smith SM, Dimitrov BD, Fahey T. Clinical prediction rules relevant to primary care that have
gone through impact analysis-a review. In preparation.
9.
Keogh C, Wallace E, Fahey T. Clinical domains and classification of clinical prediction rules relevant to primary care 1980-2008.
10.
Reulbach U, Motterlini N, Keogh C, Bennett K, O'Dowd T, Fahey T. Prescription patterns of psychostimulants in Irish children
receiving free medical care.
11.
Reulbach U, Motterlini N, Keogh C, Bennett K, O'Dowd T, Fahey T. Benzodiazepine prescribing in Irish children receiving free
medical care.
12.
Reulbach U, O’Moore M, McCrory C, Fahey T, Layte R., O'Dowd T: The association between chronic illness and bullying in Irish
nine-year-olds.
13.
Halpenny S, Pirani Z, Tracey T, Wallace E, Keogh C, Fahey T. Using clinical prediction rules in primary care.
14.
O’Kelly S, Smith SM, Wallace E, Connolly D, Lane S, O’Dowd T. Designing interventions for patients with multimorbidity: a
feasibility study of a complex intervention with structured patient assessments and occupational therapy. Planned date for submission,
15.
Cousins G, Galvin R, Motterlini N, Bradley M, Bennett K & Fahey T. Prevalence of opioid analgesics for non-malignant pain and
concurrent gastrointestinal medications in a national elderly population
16.
Cousins G, Galvin R, Motterlini N, Courtney B, Bradley M, Bennett K & Fahey T. Opioid prescriptions for non-malignant pain
and overdose in the elderly: a national population study
17.
Galvin R, Cousins G, Motterlini N, Bradley M, Bennett K & Fahey T. Prescribing patterns of glucosamine, hyaluronic acid and
chondroitin in a national elderly population
18.
Galvin R, Cousins G, Motterlini N, Bradley M, Bennett K & Fahey T. Prevalence of gabapentin, phenytoin, carbazepine and
lamotrigine in a national elderly population
Division of Population Health Sciences
List of Publications 2010-11 (cont.)
Papers submitted for publication:
1.
Keogh C, Wallace E, Dillon C, Dimitrov BD, Fahey T. A systematic review and meta-analysis of the CHADS2 rule to
predict stroke in patients with non rheumatic atrial fibrillation. Submitted to Stroke, January 2011.
2.
Ohle R, O'Reilly F, O'Brien KK, Dimitrov BD, Fahey T. A systematic review and meta-Analysis of the Alvarado score
in predicting acute appendicitis. Submitted to BMJ.
3.
Cousins G, Teljeur C, Motterlini N, McCowan C, Dimitrov BD, Fahey T. Risk of overdose mortality during the initial
two weeks after entering or re-entering methadone treatment in Scotland: Retrospective cohort study. Submitted to
Drug and Alcohol Dependence, 2010.
2.
4.
Aalbers J, O’Brien KK, Chan WS, Falk G, Teljeur C, Dimitrov BD, Fahey T. Predicting Streptococcal Pharyngitis in
Adults in Primary Care: A Systematic Review of the Diagnostic Accuracy of Symptoms and Signs and Validation of the
Centor Score. Submitted to BMC Family Practice
Callaghan C, Galvin R, Chan WS, Dimitrov BD, Fahey T. The effectiveness of botulinum toxin injection in the
management of lateral epicondylitis: a systematic review. Rejected from the British Journal of Sports Medicine,
September 2010, in preparation for BMC Musculoskeletal Disorders
5.
O’Kelly S, Smith SM, O’Dowd T. Respiratory disease and multimorbidity in general practice. Paper submitted for further
revisions to Respiratory Medicine, 2010.
Division of Population Health Sciences
List of Publications 2010-11 (cont.)
In Press:
1.
Galvin R, Geraghty C, Motterlini N, Dimitrov BD, Fahey T. Prognostic value of the ABCD2 clinical prediction rule: a
systematic review and meta-analysis. Family Practice 2011.
2.
Mullally A, Cleary BJ, Barry J, Fahey T, Murphy DJ. Prevalence, predictors and perinatal outcomes of peri-conceptional
alcohol exposure. BMC Pregnancy and Childbirth, 2010. In press
3.
Keogh C, Wallace E, O’Brien KK, Murphy PJ, Teljeur C, McGrath B, Smith SM, Doherty N, Dimitrov BD, Fahey T.
Comparing Search Strategies to Identify Clinical Prediction Rules Relevant to Primary Care. Journal of Clinical
Epidemiology, 2010. In press
4.
Cleary BJ, Donnelly J, Strawbridge J, Gallagher PJ, Fahey T, Clarke M, Murphy DJ. Methadone Dose and Neonatal
Abstinence Syndrome- Systematic Review and Meta-analysis. Addiction 2010. In press.
5.
O’Kelly S, Smith S.M, Lane S, Teljeur C, O’Dowd T. Chronic respiratory disease and multimorbidity: prevalence and
impact in a general practice setting. Respiratory Medicine 2010. In press.
Division of Population Health Sciences
List of Publications 2010-11 (cont.)
Final citation - published:
1.
Xiao L, Cousins G, Courtney B, Hederman L, Fahey T, Dimitrov BD. Developing an Electronic Health Record (EHR) for Methadone
Treatment Recording and Decision Support. BMC Medical Informatics and Decision Making, Published online, January 2011.
2.
Keogh C, Fahey T. Clinical Prediction Rules in primary care: what can be done to maximise their implementation? (Editorial). Clinical
Evidence 2010.
3.
Cleary BJ, Donnelly J, Strawbridge JD, Gallagher P, Fahey T, White MJ, Murphy DJ. Methadone and Perinatal Outcomes: a
Retrospective Cohort Study. American Journal of Obstetrics and Gynaecology, 2010 Dec 7. [Epub ahead of print]
4.
Maad S, Dimitrov BD. Digital Content Preservation Across Domain Verticals. Journal of Communication and Computer 2010; 7(10):
64-71
5.
Giesen LGM, Cousins G, Dimitrov BD, van de Laar FA, Fahey T. Predicting acute uncomplicated urinary tract infection in women: a
systematic review of the diagnostic accuracy of symptoms and signs. BMC Family Practice 2010. 11:78
6.
McNally M, Curtain J, O’Brien KK, Dimitrov BD, Fahey T. Validity of British Thoracic Society guidance (the CRB-65 rule) for
predicting the severity of pneumonia in general practice: systematic review and meta analysis. British Journal of General Practice 2010
Oct;60(579):e423-33
7.
Keogh C, Fahey T. Clinical prediction rules in primary care: what can be done to maximise their implementation? Clinical Evidence
(Online) 2010; Oct 6.
Division of Population Health Sciences
List of Presentations 2010-11
List of Presentations/Posters/Workshops
1.
2.
3.
Wallace E, Keogh C, Smith S, Dimitrov BD, Fahey T. Register of Clinical Prediction rules, methodological quality
assessment and implementation strategies. AEGS/AUDGPI Conference, 21-22nd January, Dublin.
Keogh C, Motterlini N, Reulbach U, Bennett K, Fahey T. Antibiotic prescribing in Irish children: Describing rates and
trends and comparing with EU prescribing behaviour, 8 December 2010, Faculty of Public Health Medicine, Dublin.
Corrigan D, Dimitrov BD, Fahey T. Clinical Prediction Rules as a basis for Clinical Decision Support. 15th Annual Health
Informatics Society of Ireland Conference, 18 November 2010, Dublin
4.
Corrigan D. Towards use of OpenEHR Archetypes to support views of Cystic Fibrosis Review Records. 15th Annual
Health Informatics Society of Ireland Conference, 18 November 2010, Dublin
5.
Galvin R, Callaghan C, Chan WS, Dimitrov BD, Fahey T. The effectiveness of botulinum toxin injection in the
management of lateral epicondylitis: a systematic review. Irish Society of Chartered Physiotherapists conference 12 – 13
November 2010. Dublin
6.
Halpenny S, Pirani Z, Keogh C, Wallace E, Fahey T. Development of an electronic register of clinical prediction rules
relevant to primary care. RCSI Research Summer School Symposium, 8 October 2010, Dublin.
7.
Galvin R, Geraghty CB, Motterlini N, Dimitrov BD, Fahey T. Risk of stroke following transient ischaemic attack: The
ABCD2 CPR. The Society for Social Medicine, 6-8 September 2010, Belfast
8.
Reulbach U, O’Dowd T, McCrory C, Layte R. Chronic illness and emotional and behavioural strengths and difficulties in
Irish children. The Society for Social Medicine, 6 - 8 September 2010, Belfast.
9.
Cousins G, Teljeur C, Motterlini N, McCowan C, Dimitrov BD, Fahey T. Risk of overdose mortality during the initial
two weeks after entering or re-entering methadone treatment in Scotland: Retrospective cohort study. The Society for
Social Medicine, 6-8 September 2010, Belfast
Division of Population Health Sciences
List of Presentations 2010-11 (cont.)
8.
9.
Cleary BJ, Donnelly J, Strawbridge J, Gallagher PJ, White MJ, Fahey T, Murphy DJ. Methadone and
Perinatal
Outcomes: a Retrospective Cohort Study. 26th International Conference on
Pharmacoepidemiology and Therapeutic Risk Management, 19-22 August 2010, ICPE, Brighton, UK
Cahir C. Cost-Effective Proton Pump Inhibitor Prescribing: Potential Strategies for More Rational
Prescribing. 26th International Conference on Pharmacoepidemiology and Therapeutic Risk
Management, 19-22 August 2010, ICPE, Brighton, UK
Poster Presentations –
1. Keogh C, Reulbach U, Motterlini N, Bennett K, Fahey T. Antibiotic Prescribing in Irish Children
Receiving Free Medical Care. The Society for Social Medicine, 6-8 September 2010, Belfast.
2. Keogh C, Reulbach U, Bennett K, Fahey T. Trends in Systemic Antibiotic Prescribing for Children in
Ireland. 26th International Conference on Pharmacoepidemiology and Therapeutic Risk Management,
19-22 August 2010, ICPE, Brighton, UK.
Division of Population Health Sciences
List of Presentations 2010-11 (cont.)
List of Lectures/Public Outreach/Dissemination –
1.
O’Dowd T. Chronic disease and bullying in children – Growing up in Ireland research
conference, 29 November 2010, ESRI, Dublin
2.
O’Dowd T. Chronic disease in primary care – GP study day, Tallaght Hospital, 13
November 2010, Dublin
3.
Wallace E, Keogh C, Smith SM, Dimitrov BD, Fahey T. 'Register of Clinical
Prediction Rules, Methodological quality assessment and implementation strategies.'
European GP Research Network. October 14-16th 2010. Zurich, Switzerland.
4.
Keogh C. Searching for CPRs relevant to primary care. Clinical Prediction Rules –
International Working Group, 29-30 September 2010, Oxford, UK
5.
Keogh C. Clinical domains in CPRs relevant to primary care: Preliminary results.
Clinical Prediction Rules – International Working Group, 29-30 September 2010,
Oxford, UK
6.
Dimitrov BD. New validation method. Clinical Prediction Rules – International
Working Group, 29-30 September 2010, Oxford, UK.
Division of Population Health Sciences
List of Presentations 2010-11 (cont.)
7.
Wallace E. Impact analysis studies and the evidence in relation to process and
outcome of clinical care. Clinical Prediction Rules – International Working Group, 29-30
September 2010, Oxford, UK
8.
Smith SM. Framework for the evaluation and implementation of clinical prediction
rules. Clinical Prediction Rules – International Working Group, 29-30 September 2010,
Oxford, UK
9.
Corrigan D. Usability and Clinical Decision Support Systems. Clinical Prediction Rules
– International Working Group, 29-30 September 2010, Oxford, UK
10.
Stevens R, Wallace E. Which CPRs appear in clinical guidelines. Clinical Prediction
Rules – International Working Group, 29-30 September 2010, Oxford, UK.
11.
O’Dowd T. Chronic illness in 9 year old children – Presentation to paediatrics for
Festschrift, 17 September, 2010, Dublin
Division of Population Health Sciences