Transcript Module 4

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Module 4
Clinical aspects
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Steps
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Assessment
Criteria for treatment
Treatment plan
Induction
Monitoring
Evaluation
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Assessment
• The aims of assessment are to:
– Engage the patient in the treatment
process
– Ascertain valid information
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Issues to assess
• Treat emergency
• Confirm patient is opiate dependent
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History, physical examination, urine analysis
Degree of dependence
Previous treatment history
Identify drug related problems
• Identify other medical, social and mental
health problems
• Identify motivation for treatment
• Determine the need for substitute medication
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Criteria
• Sometimes intake criteria are adopted: ICD
10 (Europe) and DSM IV (USA)
• Important is that anyone who wants to enter
substitution treatment can do so
• Assess and treat psychological, physiological
and social aspects
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Assessment
• Psychological
• Strong desire or compulsion to take the substance
• Difficulty in controlling behaviour regarding onset,
termination or levels of use
• Physiological
• Characteristic withdrawing syndrome for substance
if not taken
• Evidence of tolerance and need of increased dose
to achieve effect
• Social
• Progressive neglect of alternative
interests/pleasures and increased time necessary
to obtain, take or recover from substance
• Persisting with substance use despite the negative
and harmful consequences
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Treatment plan
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Client goals
Current circumstances
Available recourses
Patient’s expectations of treatment
Past history and outcome
Informed consent
Evidence (safety, efficacy, effectiveness)
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Induction
• Right dose varies from person to person and
from time to time
• Illicit heroin varies in purity
• Characteristics of the medication (methadone
is a long acting opiate)
• Too much medication can be fatal but too little
not effective
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Information to patient about
• Delay of peak effect of the substitute drug
• Fact that substitute drug can accumulate over
time resulting in a greater effect
• Risks of poly-drug use
• Risk of overdose
• Potential interaction with other medications
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Importance of the correct dose
• World wide clinical surveys validate the
importance of an adequate and effective dose
• Methadone between 60-120 mg
• Watters and Price (1885) reviewed 44
programmes and found that dose was the
single most important factor related to
treatment retention
• Ball and Ross (1991):
– 27% (204 pts) on <45mg used heroin in 1month period
– 5,4% (203 pts) on >45mg used heroin in 1month
period
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‘Steady state’ plasma levels
• Regular administration (same time each day)
can avoid peaks and through providing a
steady state
• Reservoirs with medication can fill up in the
liver and other tissues
• Monitoring plasma levels can be useful to test
the individual metabolism:
• 150ng/ml is the lowest level that will maintain
the 24 hour steady state
• 400ng/ml is the optimal level
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How much is enough?
• The amount required to produce the desired
response for the desired duration of time, with
an allowance for a margin of effectiveness
and safety (Payte & Khuri, 1992)
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Monitoring
• Engagement
• Drug use
• Physical and psychological health (sleep,
sex, nutrition, constipation, etc)
• Social functioning and life context
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Urinalysis
• Much debated
• Vital part of initial medical assessment
• Often used as form of control during
treatment:
• Information can also be obtained by asking
• Expensive
• Positive sample should never be a reason for
discontinuing treatment
• as this is the evidence of the condition patient
is treated for (drug dependency)
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Withdrawal symptoms
-Itching
-Rhinorrhea / lacrimation / sneezing
-Yawning
-Sweating (a cold film of sweat, best touchable in the neck
or on the upper part of the sternum)
-Pupillary dilatation
-Piloerection
-Muscle and bone aches, headache
-„Restless legs“
-Hot and cold flashes
-Nausea / vomiting
-Weakness , dysphoric mood, irritability, anxiety, insomnia
-Abdominal discomfort, diarrhea (starting with a rumbling
of the colon which may be heard by stethoscope
-Increase in blood pressure, pulse, respiratoryrate and
body
-Fever
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Overdose
• Fatal and non-fatal OD leading cause of
morbidity and mortality
• Fatal OD usually follows respiratory
depression which disrupts the oxygen supply
to the brain and causes cardiac arrest
• Likelihood increases with:
• Injecting
• Poly drug consumption
• Substitution treatment has shown to reduce
OD mortality and morbidity
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Welcome by one member of the staff
Administrative intake of personal details
Check if individual meets intake criteria (if applicable)
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Medical intake by doctor
Assessment of opioid dependence through: personal interview, medical assessment urinalysis
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Assessment of level of dependence
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Treatment plan (maintenance, detoxification)
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Induction and calculation of starting dose
Patient kept under supervision for a few hours to check if initial dose is correct
in case withdrawal symptoms reoccur, an additional dose will be given
Patient given detailed information on the treatment and on the risks of using other drugs
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Psycho-social intake by social worker/drug worker
Assessment of problems to be addressed
Liaison with relevant services
In case of co-morbidity liaison with relevant medical services
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Stabilisation period to establish the right dose (may take up to six weeks)
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Maintenance or detoxification regimen
Regular review to set new goals (depending on type of treatment)
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Programme characteristics
associated with success in MMT
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Comprehensive
Integrated
Individualised
Adequate dosing policies
Sufficient and stable staff
Sufficient staff training
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Conclusions
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Accurate assessment is vital
Take individual aspects into account
Induction with care
Provide health information