Transcript Myesthenia Gravis - faculty at Chemeketa

Myasthenia Gravis
Blaine Suing
November 21st 2007
HERE WE GO!
What is Myasthenia Gravis?
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Myasthenia gravis is a chronic autoimmune
neuromuscular disease
The name myasthenia gravis, which is Latin
and Greek in origin, literally means "grave
muscle weakness."
Myasthenia gravis is muscle weakness that
increases with activity and improves after
periods of rest.
Where does the disease take place?
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Myasthenia Gravis takes place a the
neuromuscular junction.
The areas that are most affected.
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Myasthenia Gravis mainly effects the eye lids,
eyes, and facial movement (such as chewing or
talking) which are all voluntary muscles.
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It may also affect the muscles that control
breathing, neck and limb muscles.
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Who does this affect?
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Both men and women can have the disease.
Men over the age of 60 and women under the
age of 40 are more likely to have it. But in can
come at any age.
Juvenile myasthenia gravis is not un common.
Neonatal myasthenia gravis is temporary and
usually only last 2-3 months.
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Women are affected more then men at ratio
3/2.
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In the united states for every 100,000 people,
there are 14 people with myasthenia gravis.
Treatment
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The first attempt to treat MG was on June 2nd
of 1935.
This was an injection of physostigmine.
It was performed by Dr. Mary B. Walker.
Treatment (today’s)
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There are different forms of treatment in
today's world.
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Oral pills
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IV
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prednisone, azathioprine, cyclosporine
Gammagard, Gammar-P, Sandoglobulin
Surgery
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Thymectomy
Patient Out look
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Most patients with Mg can control it with
medications or surgery.
Only in severe cases is were the patient may
have repertory distress secondary to fever or
infection.
New Studies
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One such study is testing the use intravenous
immune globlin.
Experts are studying the use of EN101
antisense
Diagnosing
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Weakness in a specific area.
Decrease strength through out the day.
Rejuvenated with rest.
Conflicting evidence
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Is thymectomy really curing the disorder, or is
stopping the progression?
Credits
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http://www.neurology.org 14 Aug 2007
http://www.mayoclinic.com/health/myasthenia-gravis Jan 19 2007
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National Institute of Neurological Disorders and Stroke November 19,
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2007
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National Institutes of Health November 19, 2007
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www.mgauk.org September 2005