Transcript Travelers
Fever in the Returning
Traveler
NIRAJ PATEL, MD, MS
INFECTIOUS DISEASES AND IMMUNOLOGY
THIS PRESENTATION
IS ON THE G: DRIVE,
“PRESENTATIONS”
65
60
55
50
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*ITA, includes travel to Canada and Mexico
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99
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45
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Number of Travelers (millions)
U.S. Residents Traveling Abroad*
Where Do U.S. Residents Travel?
Of the 17% who traveled outside the U.S. . . .
40
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20
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Infectious Disease Risks to
the Traveler
Malaria
Diarrhea
Leishmaniasis
Rabies
Dengue Fever
Typhoid Fever
Ebola
Schistosomiasis
Tuberculosis
Leptospirosis
Polio
Yellow Fever
Measles
JEV
ETC.
Travelers’ Health Risks
Of 100,000 travelers to a developing country
for 1 month:
– 50,000 will develop some health problem
– 8,000 will see a physician
– 5,000 will be confined to bed
– 1,100 will be incapacitated in their work
– 300 will be admitted to hospital
– 50 will be air evacuated
– 1 will die
Steffen R et al. J Infect Dis 1987; 156:84-91
OBJECTIVES
Recognize common signs and
symptoms in a returning traveler
Know differential diagnosis of fever in a
returning traveler
Know methods of diagnosis and
treatment of infections acquired abroad
Potential life threatening tropical
infections
Viral
- Hemorrhagic Fever (region dependant)
- Prodrome Viral hepatitis A,B & E
- HIV
- Other viral infections (Avian & H1N1)
Bacterial
- Typhoid Fever
- TB
Parasites
- Malaria
- Katayama fever
- Trypanosomiasis
Rickettsia
- Rickettsia Africae
COMPREHENSIVE ASSESMENT
History (including: Travel Questionnaire)
Thorough Physical examination
Baseline laboratories plus clinically
guided additional tests
Associated symptoms in the
returning febrile traveler
Incubation periods of travel related
infections in febrile travelers
Med Clin of N America. Vol 83, Number 4, July 1999: 997-1017.
Fever in a returning traveler
2-3% of people who travel to developing
countries*
Diarrhea and respiratory tract infections
are the most common illnesses (25-60%)
in returning travelers*
Malaria is the next most common cause of
fever in returning travelers
* Hill, DR. Health problems in a large cohort of Americans traveling to developing countries.
J Travel Med 2000; 7:259.
622 patients returning from the tropics¥
450
400
350
300
250
54
200
392
150
100
230
203
All Tropical Diseases
Malaria in Febrile
Patients
50
0
Non-related Travel
Illness
EXCLUDE MALARIA FIRST
¥ Ansart S, Perez L, Vergely O, et al. Illness in travellers returning from the tropics: a prospective study of 622 patients. J of Travel Med;2007;12:312-318.
Malaria: Basics
Plasmodium – RBC parasite
falciparum, vivax, ovale, malariae
Vector: Anopheles spp
Drug resistance varies by region
chloroquine, mefloquine, doxycycline,
atovaquone/proguanil
Malaria Fever Characteristics
80-90% of Malaria associated with fever1,2
Malaria naïve traveler – fever at lower parasitic count
Partial immunity (repeat infections) fever at higher
threshold parasitic count (flu like symptoms + d &
v1,2)
Fever as lead symptom is often irregular at onset ,
particularly in P. falciparum malaria1
EXCEPTIONS
-if patient taken chemoprophylaxis
-if P. vivax & P. ovale
1. Grobusch M, Kremsner P. Uncomplicated Malaria.Curr Topics Microbiol Immunol 2005; 295:83-104.
2. Jelinek T, Schulte C, Behrens R,et al. Imported Falciparum malaria in Europe. Clin Infect diseases 2002; 34:572-576.
Malaria: High Risk Groups
1.Children < 5yrs
Not always protected (Chemical & Physical)
Non specific symptoms – fever, lethargy,
malaise
Risk of fever complications / severe malaria /
cerebral malaria1,2
2.Pregnant woman
3.Elderly
4.Immunocompromised
5.Inhabitants of Endemic Areas whom emigrate,
lose their immunity within 6mo after absence of
re-exposure3
1. Boggild A, Kain K. Malaria: Clinical features, management and prevention. International encyclopedia of public health. Vol.5: Academic Press; 2008.p371-382.
2 Suh K, Kain K, Keystone J. Malaria. CMAJ 2004;170:1693-702.
3 Mascarello M, Allegranzi B, Angheben A, et al. Imported malaria in adults & children: epidemiological & clinical characteristics of 380 consecutive case observed in
Verona, Italy. J Travel Med 2008;15:229-36.
Diagnosis depends on identification
of organisms on blood smear
Malaria diagnosis6
CLINICAL GOLD STD
Giemsa stained thick & thin
smear
REPEAT x3; 12h’ly X
24/48h11,12
PCR – limited availability
Serology – not helpful
Clinical Clues:
Platelets (rare bleeding
unless complicated malaria,
ex. DIC)
Spleen size
11. Grobusch M, Burchard G. Diagnosis of malaria in returned travellers. Traveller’s Malaria. 2 nd ed.2008:284-299.
12. Newman R, Parise M, Barber A, et al. Malaria related deaths amongst US travellers, 1963-2001. Ann Int Med 2004;141:547-55.
Why parasites are not detected at times
in peripheral smear ?
a. partially treated patients
b. prophylactic antimalarial treatment
c. inexperienced microscopist
d. poor quality stain
e. sequestration in deep vascular bed
Malaria
algorithm
www.cdc.gov
MALARIA (UNCOMPLICATED)
Fever and any of the following:
Headache
Myalgias, arthralgias
Chills
Loss of appetite, abdominal pain
Nausea, vomiting, diarrhea
Splenomegaly
Severe Malaria (1 or more)
Parasitemia > 5% RBC
Hypotension
Hypoglycemia
Disseminated
intravascular coagulation
Impaired
consciousness/coma
Spontaneous bleeding
Severe normocytic
anemia [hemoglobin < 7]
Acidosis
Renal failure
Jaundice
Acute respiratory distress
syndrome
Repeated generalized
convulsions
Hemoglobinuria
http://www.cdc.gov/malaria/diagnosis_treatment/clinicians2.html
Current world situation regarding malaria
and drug resistance
Malaria algorithm
TREATMENT
CASE: Fever in Returning Traveler
8 yo Indian female, stayed in northern
India for one month
At end of her stay, developed bloody loose
stools, treated with metronidazole
2 days after returning to US, developed
daily fever and fatigue
Few mosquito bites, disagreement about
street food
August 2012
CASE: Fever in Returning Traveler
Hospitalized one week later with chills,
cough with fever
No prophylaxis medications taken prior to
travel
PE: T 101.4 P144 BP 106/52 R24
Gen: flat affect; Lung: decreased BS on
left; GI: occasional abdominal pain with
palpation, otherwise normal PE
CASE: Fever in Returning Traveler
Ceftriaxone was started
Fever defervesced
Stool culture negative
Malaria smears negative
PPD negative
Blood culture grew GNR
Typhoid Fever
Caused by the bacterium Salmonella typhi and less
commonly by Salmonella paratyphi
Acute generalized infection of the reticuloendothelial
system, intestinal lymphoid tissue, and the gall bladder
Always comes from another human, either ill person or
asymptomatic carrier
The bacterium is passed on with water and foods and
can withstand both drying and refrigeration
Typhoid Fever
♦ strongly endemic
♦ endemic
♦ sporadic cases
Typhoid Fever: Causes
Ingestion of contaminated food
Contact with acute case of typhoid fever
Contaminated water where inadequate sewage
systems and poor sanitation exist
Contact with chronic asymptomatic carrier
Eating food or drinking beverages that handled by
an infected person
Time frame
Occurs gradually over a few weeks after exposure.
Sometimes children suddenly become sick.
First-Stage: high fever, fatigue, weakness, headache,
sore throat, diarrhea, constipation, stomach pain, skin
rash on chest and abdominal area. Adults most likely to
experience constipation, children usually experience
diarrhea.
Second Stage: weight loss, high fever, severe diarrhea
and severe constipation, abdominal distension
Typhoid state: When typhoid fever continues untreated
for more than two to three weeks, the affected individual
may be delirious or unable to stand and move, and the
eyes may be partially open during this time. Fatal
complications such as intestinal perforation may occur.
Rose spots
Aches and pains
High fever
Diarrhea
Chest congestion
Typhoid Meningitis
Typhoid Fever: Diagnosis
Clinical history, physical exam
Cultures: stool, blood, urine, bone
marrow
Serology lacks specificity
Sensitivity of blood culture is 60%,
bone marrow is 90%
Food and Water Precautions
Bottled water
Selection of foods
well-cooked and hot
Avoidance of
salads, raw vegetables
unpasteurized dairy
products
street vendors
ice
Salmonella typhi: Treatment€
Gastroenteritis
ampicillin, amoxicillin, TMP-SMX for 10-14 d
ceftriaxone, cefotaxime, azithromycin,
flouroquinolones*
Bacteremia, osteo, meningitis, abscess
cefotaxime, ceftriaxone for 4 weeks
Dexamethasone
Delirium, obtundation, stupor, coma, shock
(Note: Relapse in 15% requiring retreatment)
€Red Book 2012
*Areas of amipicillin, TMP-SMX resistance
Cooke et al, Travel Medicine and Infectious Disease, 2004. 2:67–74.
The best known carrier
was "Typhoid Mary”;
Mary Mallon was a cook
in Oyster Bay, New York
in 1906 who is known to
have infected 53 people,
5 of whom died.
Later returned with false
name but detained and
quarantined after another
typhoid outbreak.
She died of pneumonia
after 26 years in
quarantine.
Basics
Dengue
Viral infection
“Breakbone fever”
Almost always symptomatic
Repeat infection may present as VHF
Vector: Aedes spp.
Dengue Fever
Dengue fever and dengue hemorrhagic fever are the
most common mosquito-borne viral diseases in the world
Only the female mosquito feeds on blood because it
needs protein found in blood to produce eggs. Male
mosquitoes feed only on plant nectar
Mosquito is attracted by body odors, carbon dioxide and
heat emitted from animal or humans
Aedes are most active during dawn and dusk
Short incubation period (<2 weeks)
Diagnosis confirmed by:
Dengue IgG or IgM
sero-conversion (>4)
False positive:
Yellow Fever
Japanese
Encephalitis
Dengue Fever
Vector
Precautions
Covering exposed skin
Insect repellent containing DEET 25 – 50%
Treatment of outer clothing with permethrin
Use of permethrin-impregnated bed net
Use of insect screens over open windows
Air conditioned rooms
Use of aerosol insecticide indoors
Use of pyrethroid coils outdoors
Inspection for ticks
African Trypanosomiasis: African
Sleeping Sickness
West Africa (T. brucei gambiense),
East Africa (T. brucei rhodesiense)
Aggressive tsetse fly bite
1° Chancre, 2° febrile illness, nodes, 3°
CNS disease
Diagnosis – Blood, CSF or lymph
node trypanosomes (Notify lab –
scattered therefore easily missed)
Treatment: pentamidine
(gambiense) and suramin
(rhodesiense), eflornathine (CNS)
YELLOW FEVER
Viral infection (Flavivirus)
Transmission: mosquito (Aedes or
Haemogogus)
Sub-saharan Africa and Central/South
America
.
Yellow Fever
Clinical symptoms: fever, chills,
myalgias, headache
15% progress to jaundice, shock,
hemorraghic symtoms, organ failure
Diagnosis: serology
Treatment: symptomatic
Prevention: yellow fever vaccine,
vector precautions
SUMMARY
Fever in returning traveler should prompt
evaluation for infections acquired abroad
Travel history and physical examination
are important
Malaria is the most common infection in
returning travelers, and must be excluded
Prompt diagnosis leads to improved
outcomes
Travel Health Resources
CDC Travelers’ Health Website
– www.cdc.gov/travel
World Health Organization
– www.who.int/int
State Department
– travel.state.gov
International Society of Travel Medicine
– www.istm.org
Health Information for International Travel
– CDC “Yellow Book”
International Travel and Health
– WHO “Green Book”
Katayama Fever
Clinical Diagnosis (negative Malaria)
Serology only positive 3/12 post exposure
Positive ova in urine only 45 days post exposure
1 day absolute risk swimming in Lake Malawi of
acquiring Shistosomiasis 52%-74%13
13. D’Acremont V, Burnard B, Ambresin A, et.al. Practice guidelines for the evaluation of fever in the returning traveler. J Travel Med 2003;10 Suppl 2:S25-S45.
Yellow fever risk areas-Africa
Nathnac.org
5. Geographical infections
Example: Loa Loa disease (African eye worm)
Location: West Africa rain forests
Vector: Crysops fly
Reservoir:
Human
Clinical: Eye & skin – calabar swelling
Diagnosis:
Microfilaria on Giemsa Stained
Blood smear & microscopy
Rickettsia Africae
Clinical Diagnosis
Serology only turns converts
only 7 days after exposure
Weil-Felix – poor sensitivity &
specificity
Immunizations to Consider for Adult
Travelers
Routine
Diphtheria*
Tetanus*
Pertussis*
Measles +
Mumps+
Rubella +
Varicella
Pneumococcus
Influenza
* Td or Tdap
+ MMR
Travel related
Hepatitis A
Hepatitis B
Typhoid
Rabies
Meningococcal disease
Polio
Japanese encephalitis
Yellow Fever
Exposure and Tropical
infections
Insect bites
– malaria, rickettsial infections, dengue,
trypanosomiasis
Animal - Q fever, anthrax, rabies
Human - viral haemorrhagic fever
Exposure and Tropical
infections
Raw/undercooked foods
– enteric infections, hepatitis, trichinosis
Fresh water swimming
– schistosomiasis, leptospirosis
Pathology and Pathogenesis of
Enteric fever
Caused by
S. typhi
S.paratyphi
A BC
Organisms penetrate ileal mucosa reach mesentric lymph
nodes via lymphatics, multiply,
Invade Blood stream via thoracic duct
In 7 – 10 days through blood stream infect
Liver, Gall Bladder,, spleen, Kidney, Bone marrow.
After multiplication bacilli pass into blood causing
secondary and heavier bactermia
Clinical presentation
Ingestion to onset of fever varies from 3 –
50 days. ( 2 weeks )
Insidious start, early symptoms are vague
Dull continuous head ache
Abdominal tenderness discomfort may
present with constipation.
May progress and present with step ladder
pattern temperature
Temperature fall by crisis in 3 – 4th week
Box 1: Criteria for diagnosing severe Plasmodium Falciparum Malaria
Boggild, A. K. et al. CMAJ 2009;180:1129-1131
Copyright ©2009 Canadian Medical Association or its licensors
Visiting Friends and Relatives
Foreign-born increased 57% since 1990
from 19.8 million to 31.1 million1
20% of US population are first- or
second-generation immigrants
Comprised ~46% of US international air
travelers in 20043
1US
Census Bureau, Census 2000 Brief, The Foreign-Born Population: 2000, issued Dec 2003 (Previous: US
Census Bureau, Profile of the Born Outside the United States Population 2000, issues Dec 2003???
2 Angell & Cetron, 2005
32004 Profile of U. S. Resident Travelers Visiting Overseas Destinations Reported From: Survey of
International Air Travelers, Office of travel and tourism Industries, USDOC