Transcript - Pharmapath

ETU-2
JFK Hospital Compound
CAPACITY
• Started operation: Sunday, August 17, 2014
• Unit Capacity: 35 beds
• Nursing Station:
• Suspected/probable:
• Confirmed/Critical
• Convalescent
3 beds
14 beds
15 beds
8 beds
• Daily census range from 37 – 80
– Mode:
– Average:
45
58 patients
• Census Today: 17
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Cumulative Admission:
Cumulative Positives:
Cumulative Deaths:
Cumulative Discharges
348
227
127
181
• Cumulative Confirmed Positive:
227
65.2%
– Cumulative Survivals:
101
44.5%
– Cumulative Deaths:
115
50.6%
Confirmed
Addmitted
9%
Confirmed Cases Aug 17 – Sep 30
Survivors
44%
Total
Deaths
50.6%
MAINSTAY OF TREATMENT
• SUPPORTIVE CARE
• Discharges
–Strong Contacts
–Survivals with Complications – referral
System Poor
–Orphans
–Discharge Kits incomplete
Structure of the Unit
Zones
High Risk
Moderate risk
High Risk
Structure of the Unit
High risk
Triage
Wards
Suspected
Patient Yard +
Dock
Confirmed
Ward Garbage
Convalescent
Staff
• Nurses
• Clinicians
– Doctors
– PAs`
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Psychosocial
Hygienist
Warehouse/Data Clerks
Dieticians
Securities
136
2
15
8
48
1
8
8
Infection Control Measures
– Temperature Monitoring at Staff Entrance
– Hand Washing at Staff and Patient Entrance/Exits
– Booth Baths At Low risk Zones
– Frequent Spraying of All Zones
– Avoid Contacts
– Reduction of Visitors
– Unnecessary Persons not Allowed to sit around
– Waste Disposal/Sanitation
– Team Work: Security-on-Security
Constraints
• Keeping the staff Safe
• Patient load Versus Bed space
• Procurement of Logistics and Supplies In
time
• Coordination with other partners in the
Ebola Response
• Contact Tracing
• Laboratory:
–Distance
–Work around time to obtain
results: 12 – 48 hours
Management Protocol at JFK ETU
Management Protocol
• Admission Process
–Triage for all patients
–Psychosocial Counseling
–IV line for all Patients After Triage
• WARD
–Day 0:
• Clinical Assessment
• Treatment
• Samples for EBOLA PCR
Supportive Treatment/Care for all
Patients
• Fever:
– Sponge Bath
– Paracetamol
• Body Pains:
– Paracetamol
– Tramadol
– Morphine
• Vomiting:
– Metoclopramide
– IV fluids (R/L or N/S)
• Diarrhea:
– ORS or
– IV fluids (R/L), or
– Both
• Loss of Appetite:
– Multivitamins
– Feeding
• Abdominal Pain:
– Paracetamol
– Tramadol
– Antacids
• Difficulty swallowing:
– Encourage soft diet
– Vitamin C
• Infection:
– IV Ceftriaxone/Flagyl
– Doxycycline
• Artesunate IV for malaria if very sick or
• Artesunate/Amodiaquine if tolerating Po and
mildly sick
• Weakness:
– Feeding
– Hydration
• Non-pharmacologic Treatment:
• Feeding
• ORS
• Juices
– Psychosocial counseling
– Keep the patients/Ward clean and well fed
– Amusement: Satcorn plasma televisions on ward
Investigational Drugs
Special Investigational Drug
• PHYTEXPONENT
Phytexponent
• is a preparation of alcoholic extracts of five
plants whose content in alcohol is 62.2%.
»- Viola tricolor
»- Echinaceae purpurea
»- Allium sativum
»- Triticum repens
»- Matricaria chamomilla
Phytexponent
• Put togheter by Edward CharlesVerhaeren
Phd. Pharm.; Phd Ind.Pharm.; Msc.; Bsc. Md
– From 1974 until 1987 working at Catholic
University Leuven ( Belgium)
– From 1987 until 1991 different research jobs
– Janssen pharmaceuticals Beerse Belgium (Johnson & Johnson)
– From 1991 his own Lab Aver in Belgium
Phytexponent
• Efficiency can only be explained due to :
– Using patented technology EP0938 338 B1
– Achieved synergies between plants
– Production method of the various extracts
Tightjunctions
Registrations/Notifications
• USA Checked by Fda and considered safe.
Ruling extended to safely import Sept 2007
• Niger : 05-10-2004
• South Africa : 26-07-2005
• Nigeria : 07-2005
• R D Congo : 10-02-2007
• Luxemburg : 06-07-2008
• Rwanda : 19-10-2009
• Belgium : 22-09-2011
Theoretical mode of action
• Because of its composition, PHYTEXponent
initiates the formation of CD4; it also leads to
initiation of the immunostimulating properties
of macrocytes with activation of
immunoregulatory cells from peripheral
blood. It also leads to increased susceptibility
of effector cells to alarm signals. These
immunostimulatory properties are due in par
to the active ingredients contained in
Matricaria chamomilla.
Theoretical mode of action
• PHYTEXponent has some intrinsic antibacterial
and antiviral activity due, among others, to
Alliin and echinacosides respectively
contained in Alium sativum and Echinaceae
purpurea.
Theoretical mode of action
• PHYTEXponent has a general toning effect due
to incorporation of the Echinaceae purpurea
plant into its composition. The toning and
invigorating action of Echinaceae purpurea
plant is 100 times higher than that of the
famous Ginseng.
Phytexponent
• Is safe to use as it is a FOOD SUPPLEMENT
• We only claim it is an immunebooster.
• Since the immune system of people can deal with
a great variety of viruses, bacteria fungi and
parasites we have been getting many positive
reports on many diseases.
• We have conducted very successful tests on
terminal ill Aids patients in South Africa, R D
Congo and Nigeria either in combination with
ARV or just only Phytexponent. Bringing patients
to undetectable.
Results of Phytexponent on Patients
with confirmed Ebola
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Treatment in JFK ETU
Number of patients: 17 Males: 9 Females: 8
Number of patients Expired : 5
Number of patients Discharged : 10
Number of patients Survivors : 2
Number of patients starting treatment in late
stage 5 ( 3 discharged / 2 survivors )