The immune system
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Transcript The immune system
Honors Anatomy & Physiology
Chapter 21
nonspecific
defense that is active immediately
upon infection
found in all animals & plants
includes:
outer covering
skin or shell
chemical secretions
@ openings to interior of body
skin,
mucous membranes & their secretions
highly effective barriers…unless not intact
epidermis with thick keratinized layers of
cells blocks most microorganisms
keratin resistant to most bacterial enzymes &
toxins
intact mucosae just as protective
1. Acid
acidic pH inhibits bacterial growth
(bacteriostatic)
2. Enzymes
Lysozyme in saliva, tears, sputum bacteriocidal
gastric enzymes also bacteriocidal
3. Mucin
+ water sticky lining of digestive &
respiratory passages: traps pathogens
4. Defensins:
broad-spectrum antimicrobial peptides secreted
by mucous membranes & skin
5. Other: lipids in sebum & dermicidin in eccrine
sweat toxic to bacteria
1. Phagocytes:
Neutrophils
become phagocytic when find infectious
material
Fixed & Wandering Macrophages
from monocytes
2. Natural Killer Cells
in lymph
phagocyte
must adhere to pathogen in order
to ingest it
bacteria with external capsules elude capture
Opsonins: proteins released by immune cells
that coats the capsules (opsonization)
phagocytes can capture them
nonspecific
killers of any cell w/out “self” cell
surface markers
travel through body patrolling for:
virus-infected cell
cancer cells
Not
phagocytic
induce target cell apoptosis
secrete potent chemicals that enhance
inflammatory response
triggered
when tissues injured by:
physical trauma
2. intense heat irritating
3. chemicals
4. infection by viruses, fungi,
or bacteria
1.
beneficial
1.
2.
3.
4.
effects:
prevents spread of damaging agents to
nearby tissues
diposes of cell debris & pathogens
alerts adaptive immune response
sets stage for repair
*ultimate goal: clear injured area of
pathogens, dead tissue cells, other debris so
tissue can be repaired
1.
2.
3.
4.
Redness
Heat
Swelling
Pain
1st
step: “chemical alarm”
chemicals released by:
injured or stressed cells immune cells
mast cells histamine
macrophages recognize type of invader using
surface receptors called TLRs and release specific
chemical in response triggers release of
cytokines
other
chemicals released:
kinins
prostaglandeins
complement
1.
2.
vasodilation hyperemia (congestion with
blood) 2 of cardinal signs: redness & heat
increased permeability = exudate other 2
cardinal signs: swelling (edema), pain
capillaries allow fluid containing clotting
factors & antibodies swelling pain
macrophages
predominant cell cleaning up
cell debris @ sites of prolonged or chronic
inflammation
pus: mixture of dead or dying neutrophils,
damaged or dead tissue cells, living & dead
pathogens
if inflammatory response has failed to clear
area collagen fibers may be laid down
walling off area abscess: may require
surgical drainage to heal
1. Interferons
secreted by cells in response to viral
invasion
not viral specific
help nearby cells make proteins that
interfere with viral replication
2. Complement provides major mechanism for
destroying foreign substances in body
releases inflammatory chemicals
lyses & kills certain bacteria
abnormally
high body temperature
pyrogens: chemicals released by neutrophils &
macrophages alters thermostat in
hypothalamus
adaptive response that benefits body:
1. liver & spleen sequester iron & zinc making
them less available to support bacterial
growth
2. increases metabolic rate of tissue cells in
general
https://www.khanacademy.org/science/hea
lth-and-medicine/human-anatomy-andphysiology/introduction-toimmunology/v/inflammatory-response
body‘s
built -in specific defense system
3 features:
1. Specific
2. Systemic
3. Memory
2 parts
1. Humoral or antibody-mediated immunity
B Cells
2.Cellular or cell-mediated immunity
T Cells
1.
complete antigens
2. incomplete antigens
Functions:
1.
2.
Immunogenicity: ability to elicit certain
lymphocytes to proliferate (multiply)
Reactivity: ability to react with activated
lymphocytes & the antibodies released
B
lymphocytes T lymphocytes
make antibodies cellular immunity
humoral
mature in thymus
immunity
1. Immunocompetence
mature in bone
ability of immune cells
marrow
to recognize (by binding)
to specific agns;
recognition implies
presence of plasma
membrane receptors
2. Self-tolerance
APCs
engulf
agns present fragments of them
onto their cell-surface markers
major types:
1. Dendritic cells
2. Macrophages
3. B cells
most
important APC (only job they have)
internalize agn migrate to nearest lymph
node present agn to T cells
present
agns to T cells in order to be activated
by effector T cells release chemicals that in
turn activate the macrophage increases
their phagocytic activity
do
not activate naïve T cells like dendritic
cells or macrophages
only present to T helper cells in order to get
help for their own activation
once
activated, most of the clone members
become effector cells = plasma cells
plasma cells secrete antibodies
rest
become memory cells
http://web.biosci.utexas.edu/psaxena/Micro
biologyAnimations/Animations/HumoralIm
munity/micro_humoral.swf
Memory
cells capable of mounting a rapid
attack against the same antigen in any later
encounters (secondary immune response)
Memory B cells provide humoral
immunological memory
http://web.biosci.utexas.edu/psaxena/Micro
biologyAnimations/Animations/HumoralIm
munity/micro_humoral.swf
acquired
during
1st exposure to
agn:
Infection
Vaccination
provides memory
acquired
Active
through
injection of abys into
body
passage of abys
from mother
fetus in utero
passage of abys to
newborn in
breastmilk
*NO MEMORY
Passive
Immune
system exposed
to harmless version of pathogen
triggers active immunity
stimulates immune system to produce
antibodies to invader
rapid response if
future exposure
Most
successful
against viral diseases
1914 – 1995
April 12, 1955
Developed
first vaccine
against polio
attacks motor neurons
Albert Sabin
1962
oral vaccine
4
polypeptide chains
2 heavy chains
2 light chains
held together by disulfide bonds
constant
areas determine function & aby class
variable area enable recognition of specific
agn
1.
2.
3.
4.
5.
Ig M: 1st aby secreted from plasma cell
during 1◦ response, potent agglutinator
Ig A: found in body secretions: saliva,
sweat, milk, blocks attachment of agns to
mucous membranes
Ig D: functions as B cell membrane agn
receptor
Ig G: most #’s in plasma, main aby of 1◦
& 2◦ responses, only 1 to cross placenta
Ig E: binds to mast cells & basophils
release histamine, levels rise during
allergic rx or chronic parasitic infections
of GI tract
http://highered.mheducation.com/sites/0072507470/stude
nt_view0/chapter22/animation__the_immune_response.ht
ml
pure
preparations (a clone) of a single aby
type
useful in diagnostic tests
1.
2.
3.
pregnancy
STDs
Hepatitis
treating some types of cancer
Leukemia
Lymphomas
You need trained assassins to kill off these
infected cells!
T
Attack
of the
Killer T cells!
2007-2008
agn
presentation to T cells provokes
cellular immune response
2 major populations of T cells (based on
which of 2 surface proteins a mature T cell
displays:; both memory cells:
1. CD4 = helper T cells: TH
activate B cells, macrophages
direct adaptive immunity (does not happen
w/out TH
CD8= cytotoxic T cells: TC
2.
destroy any cell in body that has anything
foreign in it
infected cell
killer
T cell
or
activated
macrophage
helper
T cell
helper
T cell
stimulate
B cells &
antibodies
helper
T cell
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
helper
T cell
Y
Y
Y
interleukin 1
activate
killer T cells
Y
helper
T cell
Destroys
infected body cells
binds to target cell
secretes perforin protein
punctures cell membrane of infected cell
Killer T cell
binds to
infected
cell
infected cell
destroyed
Killer T cell
vesicle
cell
membrane
perforin
punctures
cell membrane
target cell
cell
membrane
http://highered.mheducation.com/sites/0072507470/st
udent_view0/chapter22/animation__tcell_dependent_antigens__quiz_2_.html
skin
free antigens in blood
humoral response
Y
Y antibodies
Y
Y
Y
Y
memory
B cells
Y
Y
Y
Y
Y
macrophages
(APC)
helper
T cells
B cells
plasma
B cells
pathogen invasion
antigen
exposure
skin
antigens on infected cells
cellular response
T cells
memory
T cells
cytotoxic
T cells
cell-mediated
responses reject grafts & foreign
transplants unless the recipient is
immunosuppressed
infections are major complications
SCID
1.
Severe Combined Immunodeficiency
group of genetic disorders deficit of
functioning T and B cells
untreated:fatal
tx:bone marrow transplant
acquired immunodeficiencies
1.Hodkins lymphoma
2. AIDS
Human
Immunodeficiency Virus
virus infects helper T cells
helper T cells don’t activate rest of immune system: T
cells & B cells
also destroy T cells
Acquired
ImmunoDeficiency Syndrome
infections by opportunistic
diseases
death usually from other
infections
pneumonia, cancer
occurs
when the body regards its own tissues
as foreign & mounts an immune attack
against it
Rheumatoid arthritis
Graves disease
Hashimoto’s thyroiditis
Multiple sclerosis
Celiac disease
Lupus (SLE)
abnormal
reaction to otherwise harmless agn
immediate hypersensitivity
1.
allergies/ Ig E aby
2. subacute hypersensitivity:
abys & complement
3. delayed hypersentsitivity:
cell-mediated
4
attributes that characterize the immune system
as a whole
specificity
diversity
react to millions of antigens
memory
antigen-antibody specificity
rapid 2° response
ability to distinguish self vs. non-self
maturation & training process to reduce auto-immune
disease