Transcript Allergy and Hypersensitivity

Allergy and Hypersensitivity
K. J. Goodrum
2006
Types of Immune Hypersensitivity Reactions
Types of Immune Hypersensitivity Reactions
Properties of Inhaled
Allergens
Penetration of epithelial Barriers by Allergens
Early IL-4 response promotes Th2 development
that drives B cell class switching to IgE
Signaling through
Stat6 is necessary for
Th2 responses.
Th2 cells support IgE
responses.
Antigen binding to IgE on mast cells leads to
amplification of IgE production
Mast cell
activation
affects many
tissues
Molecules released upon activation of mast cells
Molecules released upon activation of mast cells
Toxic granule proteins and inflammatory substances
released upon activation of eosinophils
Toxic granule proteins and inflammatory substances
released upon activation of eosinophils
Acute vs.
late phase
inflammatory
responses
TH2 mediated chronic inflammation in Asthma
Treatment approaches for IgE-mediated Allergy
Type II
Cytotoxic
reaction
Immune Complex mediated local inflammation such as
in Arthus Reaction
Serum Sickness: an Immune complex disease
Type IV Hypersensitivity Reactions
Stages of a Type IV Hypersensitivity Reaction
Th1 derived
cytokines and
chemokines
direct Type IV
reactions
Allergic Contact Dermatitis: A type IV reaction
Blistering skin
lesions on hand of
patient with poison
ivy contact dermatitis
(a type IV reaction)
Granulomatous inflammation
is a consequence of chronic
Type IV reactions