the immune system phagocytosis antibody
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Transcript the immune system phagocytosis antibody
Immune system
By the end of the lesson you should be
able to
Outline the stages in phagocytosis.
Describe how antibodies work and how
they are specific.
First lines of defence
saliva
antibacterial
enzymes
skin
prevents
entry
stomach acid
low pH kills
harmful
microbes
tears
antibacterial
enzymes
mucus linings
traps dirt and
microbes
“good” gut
bacteria out
compete bad
Pathogens
= disease causing micro-organisms
bacteria
virus
fungi,
protozoa,
parasite,
prion
Second lines of defence
Involves white blood cells
Non-specific response
invading pathogens are
targeted by macrophages
Specific response
lymphocytes produce chemicals
called antibodies that target
specific pathogens
Phagocytes
Phagocytes
Monocytes and macrophages
Provide a non-specific response to
infection
http://www.microbelibrary.org/imag
es/tterry/anim/phago053.html
Phagocytosis
Stages in phagocytosis
1. Phagocyte detects chemicals released by a
foreign intruder (e.g. bacteria)
2. Phagocyte moves up the concentration
gradient towards the intruder
3. The phagocyte adheres to the foreign cell
and engulfs it in a vacuole by an infolding of
the cell membrane.
4. Lysosomes (organelles which are rich in
digestive enzymes & found in the
phagocytes cytoplasm) fuse with the
vacuole & release their contents into it.
Phagocytosis
5. The bacterium is digested by the
enzymes, and the breakdown products
are absorbed by the phagocyte.
During infection, hundreds of phagocytes
are needed.
Pus is dead bacteria and phagocytes!
link to phagocytosis
Pus
An accumulation of : dead phagocytes
destroyed bacteria
dead cells
Lymphocyte
Lymphocytes
Provide a specific immune response to
infectious diseases.
There are 2 types: - T-cells
- B-cells
They produce antibodies.
Antigens
all cells have
surface markers
called antigens.
body can recognise
these as self or
non-self (foreign)
Specific response
Lymphocytes detect presence of foreign
antigens
Stimulated to produce
specific proteins called
antibodies.
antibodies combine with their specific
antigen (like a lock and key)
this renders the pathogen harmless.
= primary response
Immunity
= the bodies ability to resist infection
can be natural or acquired
Immunological memory
after an infection is fought off some
lymphocytes become memory cells.
if same pathogen returns memory cells stimulate
the produce the specific antibody very rapidly.
the infection is fought off before symptoms
appear = secondary response
vaccines can stimulate same response
Immune system
Can you
Outline the stages in phagocytosis.
Describe how antibodies work and how
they are specific.
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