Transcript Processing & Production Committee

Consumer Insights,
Nutrition & Community
Committee
Kathleen Nave, Chair
January 26, 2009
Sacramento, CA
Consumer Insights, Nutrition
& Community
• Grape Health Workshop
– December 2-3, 2008 in San Francisco
– Seven areas of emphasis
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Cardiovascular
Cancer
Cognitive Function/Brain Health
Immune Function
Diabetes/Glycemic Response
Anti-microbial/Anti-adhesion
Bioavailability/Analytical
Consumer Insights, Nutrition
& Community
• Workshop Goals
– Establish a consensus about research areas
of promise
– Provide information needed for gap analysis
– Stimulate discussion among key researchers
– Provide direction to the grape industry
– Publish papers presented in applicable
professional journal
Dr. Joseph Vita, Cardiovascular
• Most research data on wine; some on
juice
• Benefit to vascular endothelium (cells
lining inside of blood vessels)
• Improvement of platelet function, blood
pressure, reduced clots, protection of LDL
cholesterol and anti-inflammatory effect
Dr. Susan Zunino,
Diabetes/Glycemic Resonse
• Diabetes: defects in pancreatic beta-cell
function & decreased disposal of glucose
in tissues – also inflammatory molecules
produced by fat tissue
• Resveratrol and grapeseed procyanidins
lowered blood glucose
• Quercetin protected beta cells
Dr. Sue Percival
• Can grapes improve surveillance mode of
immunity – priming T-cells for immunity
enhancement & anti-inflammatory
benefits?
• Work with Muscadine & Cabernet wines
• Grapes may influence “functional immunity
tests” in animals & people
• Next step underway: looking at preventing
illness
Dr. Raja Aggarwal, Cancer
• Work with grapeseed extract on cancer
• Animal studies: benefits on the following
cancers: colon, breast, skin, prostate,
head and neck
• Proanthocyanidins are key component
Dr. James Joseph, Brain Health
• Work primarily with blueberries,
extrapolated to grapes
• Polyphenols may decrease sensitivity to
oxidative stress
• Oxidative stress and inflamation are “the
evil twins of brain aging”
• Verbal memory of human subjects
improved with grape juice
Dr. Christine Wu, Dental health
• Grapes may suppress growth factors of
oral pathogens associated with cavities,
gum disease and band breath
• Most work conducted with raisins, which
show some anti-microbial activity
• Fresh grapes drop pH, but effect is quickly
neutralized above 6.1
Dr. Andy Waterhouse
• Bioactive substances in grapes & wine
including polyphenolic compounds &
metabolites
• Phenolics have low absorbtion rates &
quick excretion
• Metabolites of phytonutrients may be more
potent and should be studied further;
these include catechins, anthocyanins,
procyanidins and quercetin
Considerations, cont…
• Cardiovascular research
– Pool research for a human study
– Blood pressure (biomarker for heart disease)
has shown positive results
Brain health research in humans
Welch’s study
CTGC studies on Alzheimer’s; grapes &
mechanism affecting brain
Considerations, cont….
• Metabolite activity
– Review grape polyphenolic compounds
– Possible to analyze human blood samples
from human studies already completed or will
new collective research be needed?
Grape Seed Extract
Is this applicable to all NGWI products? If not,
perhaps work in this area shouldn’t be
undertaken by NGWI