Transcript Immune Mechanisms

Immune Mechanisms
Chapter 29
Immune Cells
B and T Cells
Innate Response: Phagocytosis
of Bacillus megaterium
Toll Like Receptors: PAMP and PRR
Oxygen Dependent Killing in the Phagolysosome
Inhibiting Phagocytosis
1. Staphylococcus aureus carotenoids, Mycobacterium tuberculosis cell
wall glycolipids :: absorb ROS.
2. Staphylococcus aureus, Streptococcus pyogenes :: leucocidins –
toxins that kill phagocytes  pus.
pyogenic = pus forming pathogens.
3. Streptococcus pneumoniae capsules, S. pyogenes M protein – inhibit
phagocytosis.
Antibodies specific to capsules, M protein…overcome this escape
mechanism…Ab dependent phagocytosis.
Adaptive Immune Response
Clicker Question:
Adaptive Immune Response
Clicker Question:
Adaptive Immune Response
Clicker Question:
Three Immune
Characteristics
applies to both
Antibody Response
and Cellular
Response
Immunogens
Proteins > Polysaccharides >>>>> DNA >>>lipids
Antigen Binding
Clicker Question:
Tcell Receptor and MHC and Ag Presentation
MHC-I
T-cell Receptor
MHC-II
Tcell Receptor Binds Ag Presented by MHC
TC cell = Cytotoxic T-cell
TH cell = Helper T-cell.
TC Cells Killing
NK Cells
TH1 Cells Helpers
TH2 Cells Helpers
TH17 cells, secrete IL-17
and other cytokines to
attrach Neutrophils to sites
of infection…
….independent of Ag
contact (activated by
dendritic cells)
Antibodies
IgG
Disulfide bonds
circled in Red
Antibodies
IgG vs IgM
IgM (in blood)
Clicker
Question:
IgA: Excreted to Mucosal Surfaces
Clicker Question:
Ig Light Chain Molecular Biology
Hey, we had this slide Last Class
Clicker Question:
Complement Holes in Salmonella enterica
Complement is So Cool !
Complement is So Cool !
3 Pathways of Complement Activation