Transcript Immune System Day 3

Immune System Day 3
Health can be
squandered, but
not stored up.
Mason Cooley (b.
1927),
Today’s Agenda
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Turn in your colored lymph node if you’ve not
done so already.
Progress reports
Notes on immune system
Practice identifying parts
Describe last illness
Non-specific immunity
Other Lymphoid Organs:
These organs don’t filter but do contain macrophages and
lymphocytes.
 1.
Spleen:
– a.Destroys
old or defective red
blood cells
– b.Stores platelets
– c.Acts as a hematopoietic site in the
embryo and in severe cases of
anemia
Other Lymphoid Organs:
These organs don’t filter but do contain macrophages and
lymphocytes.
 2.Thymus
– A.
gland
Most functional during youth
– B. Its hormones cause T
lymphocytes to become
immunocompetent.
Other Lymphoid Organs:
These organs don’t filter but do contain macrophages and
lymphocytes.
 3.Tonsils
– A.Small
and Peyer’s patches
organs known collectively ast
GALT (gut-associated lymphatic
tissues).
– B.Prevent pathogens in the respiratory
and digestive tract from going through
the mucous membrane lining
Obj. 5 Nonspecific Defenses: things your
body uses to defend against ANYTHING
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Skin & mucous membranes
Phagocytic cells
Natural killer cells
Inflammatory response
Antimicrobial substances
Fever
Obj. 5 Nonspecific Defenses: things your
body uses to defend against ANYTHING
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1. Skin & mucous membranes
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Obj. 5 Surface Membrane Barriers
Role=prevent pathogens from entering body
 Protective membranes line all body cavities
and organs exposed to the exterior.
 Surface membranes provide mechanical
barriers to pathogens.
 Structural modifications and produce
secretions that enhance their defensive
effects (skin acidity, lysozymes, mucus, keratin,
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cilia)
Bacterial leprosy infection just under skin.
“border line leprosy—numb centers
2. Phagocytic cells-macrophages
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Phagocytes include macrophages and
neutrophils
Phagocytes engulf and destroy
pathogens
Phagocytosis is enhanced when
pathogens surface is altered by
antibodies or complement proteins
Cell killing is enhanced by respiratory
burst
Obj. 6
Natural killer cells – attack
and lyse body cells infected by
viruses or that are cancerous.
 3.
Obj.
7 Inflammatory
1. Skin
& mucous membranes response
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2. Phagocytic cells
3. Natural killer cells
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4.
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Inflammatory response
damaged tissues release
histamines
– Histamines make vessels leaky,
releasing phagocytes & clotting
factors
– Phagocytes engulf bacteria
– Platelets form clots
–
Obj. 7
Obj. 5 Nonspecific Defenses: things your
body uses to defend against ANYTHING
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Antimicrobial
substances
– Interferon
– Complement
proteins
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1.
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5.
Skin & mucous membranes
Phagocytic cells
Natural killer cells
Inflammatory response
Antimicrobial substances
 6.
Obj. 8 Fever
Fever
– Macrophages
105
release pyrogens
– Hypothalamus elevates
temperature
– Liver & spleen supply less iron
– Bacteria don’t grow well without iron
– Metabolism increases speeding
repair.
98.6