Transcript Challenges to Childhood Immune Systems

www.vaccinationcouncil.org
This vaccine webinar series is provided as a community service by Homefirst Natural Pharm Source
www.homefirst.com
Marini 2004
A Medical School Professor
of Immunology’s Lesson for
All Physicians
NEUROIMMUNOLOGY PATTERNS OF INTERFERENCE
Stephen C. Marini, M.S., D.C.,
Ph.D
Stephen C. Marini, M.S., D.C., Ph.D
Family
Chiropractic Center
3301 Ryan Avenue
Philadelphia, PA 19136
Tel: (215) 332-8686
Fax: (215) 332-8691
Ciccarone Chiropractic
& Rehab Centers
144 East DeKalb Pike, Suite 202
King of Prussia, PA 19406
Tel: (610) 337-3555
Fax: (610) 337-8235
E-Mail: [email protected]
Marini 2004
CHANGING PARADIGMS
Mechanistic:
CHEMISTRY
STRUCTURE
FUNCTION
Vitalistic:
ENERGY FIELD
UNIFIED FIELDS
CHEMISTRY
STRUCTURE
FUNCTION
Marini 2004
The Current Consensus Model of the Immune System and Its Relationship
to the Neuroendocrine System
Immune System
Humoral
Immunity
Antibodies
T Helpers
Cytokines
Cell-Mediated
Immunity
Cellular
Cytotoxicity
DTH
Antigen-presenting
Cells
Stem cells,
Cytokines
Reticuloendothelial
System
Haemopoietic
System
Marini 2004
Neuro-endocrine
System
Regulation of Immune Responses and the Involvement of Other Systems
Immune System
Haemopoietic
System
Positive
Regulators
T Helpers
Humoral
Immunity
Antibodies
Cell-Mediated
Immunity
Cellular
Cytotoxicity
DTH
Negative
Regulators
T Suppressors
Marini 2004
Reticuloendothelial
System
Marini 2004
Marini 2004
OPTIMUM IMMUNITY
THE HUMAN IMMUNE SYSTEM: YOUR MOST RESPONSIVE ALLY
PNI (Psychoneuroimmunology)
PSYCHO – Experience, Interpretation, Translation, Transformation, Mind,
Thoughts, Feelings, Notions, Memory, Opinions, Spirit, Soul, Energy-information, Unified
Fields
NEURO – Brain (right and left), Spinal cord, Cranial nerves, Spinal nerves, Autonomic
nervous system, Memory, Neurotransmitters, Neuropeptides, Neurohormones, Interference
by the VSC (Vertebral Subluxation Complex)
IMMUNO – Central and peripheral lymphoid organs, T cells, B cells, Antigen processors,
Lymphokines, Cytokines, Neurochemicals, Memory
GASTROENTERO – Gut associated lymphoid tissues, Lymphokines, Neurotransmitters, Breast
feeding, Oral tolerance, Memory, Gut reactions
MUSCULOSKELETAL – Receptors, Biomechanics, Posture, Memory, Spinal Learning,
Interference from VSC, Exercise Neurochemistry
Marini 2004
Rationale For Immunization
Immunoprophylaxis/Primary
Prevention
Herd Immunity
Pre & Post Exposure Immunization
Marini 2004
TYPES OF IMMUNITY &
IMMUNIZATION
Active
Passive
Natural
Artificial
Marini 2004
T HELPER CELL SUBSETS
Th 1 Cells (CD4+)
These cells mediate functions connected with cytotoxicity and local
inflammatory reactions. Th 1 cells promote development of Tc Cells, the expression
of the delayed hypersensitivity, and the production of 1gG2a.
This subset secretes gamma interferon, interleukin 2,3 tumor necrosis
factor, lympotoxin, and antibody mediated cell cytotoxicity. Regulation of the Th 2
reactions.
Th 2 Cells (CD4+)
This subset directs immune responses toward production of IgE (atopic diseases),
IgA, IgG1.
Eosinophil proliferation via interleukin 5, and mast cells via Il-3 and 4. Th 2 cells
secrete Interleukin 3,4,5,6,10. Interleukin 4,5,6 stimulate antibody production.
The Th subsets down-regulate one another
1.
Gamma interferon secreted from Th 1 cells suppresses the maturation of Th 2
cells and suppresses the enhancing effect of IL-4 produced by the Th 2 cells on IgE
and IgG1 – synthesis
2.
IL-10 secreted the Th 2 cells suppresses production of Th 1 cells
3.
Il-10 possesses cross-regulatory role of inhibiting cytokine synthesis by Th 1 cells
IMMUNOGENS ELICITING A STRONG CELL MEDIATED RESPONSE WILL INHIBIT HUMORAL
ACTIVITY
STRONG HUMORAL RESPONSES INHIBIT CELL MEDIATED RESPONSES TO THE SAME
ANTIGEN
Marini 2004
Ab Titer
Ab Titer vs. Time
Time
Th2 Humoral Immune Response
Ab Titer Values
Ab Titer
Ab Titer Values
Marini 2004
Time
Th1 Cell-Mediated Response
Ab Titer Values
Prenatal Skewing toward Th2
•
Natural
•
Artificial/Environmental
Neonatal/Infantile Th1 Stimuli
•Birth Canal Flora
Neonatal/Infantile Inhibitors to
the Th1/Th2 Balance
•Colostrum
•C Sections
•Breast Milk
•Vaccinations
•Prebiotics
•Antibiotics
•Probiotics
•Formula Feeding
•Environmental exposure
•Dysbiosis
•Viruses
•Gram negative bacteria
•Fungi
Marini 2004
JOURNAL ARTICLE
ISSN
0367-6102
Country of Publication
JAPAN
Database: med93-95 – Record 2 of 4 selected.
Title
Vaccine strategies: targeting helper T cell responses.
Author
Golding B; Scott DE
Address
Laboratory of Plasma Derivatives, United States Food and Drug Administration, Bethesda,
Maryland 20892, USA
Source
Ann N Y Acad Sci, 754(-VI-):126-37 1995 May 31
Abstract
Vaccine strategies need to take into account the balance of T helper subsets they induce. TH1
cells, which secrete IFN gamma and IL-2, are associated with CMI, rather than humoral
responses, and afford protection against intracellular infections including parasites. In
contrast, TH2 cells secrete IL-4, IL-5, and IL-10; elicit high-titer antibody responses and poor
CMI; and are associated with susceptibility to infection with intracellular pathogens.
Depending on the type of TH cell bias required, it is possible to manipulate the immune
response to a protein or peptide by employing (1) different adjuvants, (2) conjugating the
protein to various carriers, (3) immunizing in the presence of cytokines, (4) using alternative
routes of administration, or (5) using different forms or doses of antigen. To apply these
approaches to a particular vaccine, it is necessary to identify which component of the infection
agent (e.g., envelope protein or peptide) or allergen to target. Once the type of TH cell
response that is protective is identified, it may be possible to combine a protein with an
adjuvant or link it to a carrier that will promote responses towards the most advantageous TH
subset.
Marini 2004
PRIMARY & SECONDARY
IMMUNE RESPONSES
ANTIBODY FORMATION
A. Antibody Response following Immunization
1* Response
2* Response
Ab
Concentration
75
IgG
IgM
195
1. A summary of the
solvent features of the
primary & secondary
immune responses
5
10
15
45
20
25
30
35
40
DAYS
Characteristic
Dose of Immunogen Required
Induction Period
Total Antibody Produced
Duration of Response
IgM antibody produced
IgG antibody produced
Marini 2004
Primary Response vs. Secondary Response
>
<
<
<
=
<
VACCINE TYPES
Whole Organisms (Bacterial)
Live Attenuated
Tuberculosis (BCG)
Typhoid
Viral Particles
Live Attenuated
Inactivated
Anthrax
Cholera
Pertussis
Plague
Inactivated
Measles
Hepatitis A
Mumps
Influenza
Rubella
Polio (IPV) Salk
Polio (OPV) Sabin
Rabies
Varicella
Yellow Fever
Rotavirus
DNA
Vaccines/Genetically
Engineered Satellite DNA
Marini 2004
Purified
Macromolecules
Toxoids (Inactivated
Exotoxin)
Diphtheria
Tetanus
Capsular Polysaccharides
Haemophilus influenza, Type B
(HIB)
Neisseria Meningitides
Streptococcus Pneumoniae
Surface Antigens
Hepatitis B (Recombinant
surface antigen)
HbsAg
TYPICAL COURSE OF AN AUTISTIC PATIENT
1. Hepatitis B immunization at 12 hours after birth. DPT immunization at 4 and 8 weeks*,
oral polio immunization also at 4 and 8 weeks, again at 3 months. Schedule now being
changed; children will receive 2 doses of live attenuated oral polio and 2 doses killed
polio; oral polio can cause disease; only killed polio is used in Europe.
2. Because of great decrease in cell-mediated immunity (CMI) in infants, the vaccines lower
CMI further; one decreases CMI by 50%; two together by 70%. Longest safety trail of the
triple vaccine (MMR, all live attenuated viruses) was three weeks.
3. Repeated immunizations with 3 vaccines simultaneously, e.g., Pneumococcus,
Haemophilus, etc. from 4 weeks to 12 to 18 months. Repeat DPT is given at 12 months.
*All these triple vaccines markedly impair CMI.
4. Resultant decrease in CMI predisposes to recurrent viral infections, especially otitis media,
since CMI controls response to viruses (also fungi [e.g., Candida], parasites [e.g.,
leishmaniasis], mycobacterium [e.g., tuberculosis, even if drug resistant] and leprosy).
5. When infections occur, bacterial cultures rarely performed, yet infants repeatedly given
antibiotics. Antibiotics are of absolutely no help in viral infections; in some countries,
antibiotic administration without a prior culture is considered malpractice.
6. Antibiotics wipe out helpful bacteria in the gut (e.g., lactobacilli, bifidobacteria), which
have important protective functions, including prevention of infection by yeast, pathogenic
bacteria, and/or parasites. The protection is provided in part by the helpful bacteria
clinging to the intestinal cell wall, thus preventing pathogenic microorganisms from getting
to it. The pathogenic bacteria compete with the body for vitamin B-12 and perhaps other
vitamins and minerals.
Marini 2004
Breast Feeding







(PNIEG) PSYCHONEUROENDOCRINOIMMUNOGASTROINTESTINONUTRITION
• BREAST MILK vs. FORMULA

TOXICITY
• MOTHER – FETUS
• MOTHER - BABY
Marini 2004
Marini 2004
Marini 2004
IMMUNIZATION QUESTIONS
AND ISSUES
1. Are vaccines effective?
Temporary immunity/deferred susceptibility.
2. Are vaccines safe?
Doctors, legislators, parents not informed.
3. Informed consent or conscription?
4.
•
•
•
•
•
•
Avoid vaccine reactions by asking:
Is my child sick right now?
Do I know if my child is at risk?
History in family of vaccine reactions or health problems?
Do I know the adverse reactions to the vaccines given to my child?
Do I know the manufacturer and lot number of the vaccine?
Do I know how to report an adverse reaction?
5. Do I know my rights under the state law to exempt my child from vaccines?
6. If I choose not to vaccinate my child, do I know how to recognize and
appropriately manage illnesses that vaccines protect against?
Marini 2004
CURRENT VACCINATION CONCERNS
1. Emergency State Powers Act
2. State Registry
3. Exemptions Under the Law
4. Thimerosal and Vaccines
5. Autism and Vaccines
•
Mercury Induced
•
Autistic Enterocolitis
• Immune Complex Disorder
Marini 2004
Marini 2004
Immunostasis
Th1/Th2 Balance
High Ratio FXN
CMI (Cell Mediated
Immunity)
Surveillance
Tolerance
Cytotoxicity
Infection Externalization
Intracellular Infection
Th2Th1
UpUp
Regulators
Regulators
Vaccinations
Welfare Consciousness Patterns
Antibiotics
Antioxidants
Emergency
Consciousness
Glucans &
Mushroom Extracts
Sympathetic
Melatonin Activity+HPAC
Purulent
Parasitic Infection
DHEA&(Dehydroepinandrosterone)
Trans
& Saturated
Selenium,
Zinc Fats, 6EFA
Oxidation
Damage
Probiotics
Mercury
BreastToxicity
Feeding
Nicotine
and Caffeine
Fish Oils
Progesterone
Beta Sterols (Beta-sitosterol &
sterolin)
Sugar
Viral and Bacterial
Environmental
Toxins,Inf.
Hormones,
Pesticides,
Diesel
Fumes
Dirt, Dust,
Dander
Food Deprivation
Marini 2004
Low Ratio FXN
Humoral Immune
Atopic Dermatitis
Allergies & Asthma
Eczema/Psoraisis
Infection Internalization
Toxin Neutralization
Extracellular Infection
System Autoimmunity
(Lupus, Graves, Type II
Diabetes, RA)
Cancer
AIDS
MAP OF CONSCIOUSNESS
God-view
Life-View
Level
Log
Emotion
Process
Self
Is
Enlight700- Ineffable
Pure ConEnment
1000
sciousness
All-Being
Perfect
Peace
600 Bliss
Illumination
One
Complete
Joy
540 Serenity Transfiguration
Loving
Benign
Love
500 Reference
Revelation
Wise
Meaningful
Reason
400 Understanding Abstraction
Merciful Harmonious Acceptance 350 Forgiveness
Transcendence
Inspiring
Hopeful
Willingness 310 Optimism
Intention
Enabling
Satisfactory Neutrality
250 Trust
Release
Permitting
Feasible
Courage
200 Affirmation Empowerment
Indifferent
Demanding Pride
175 Scorn
Inflation
Vengeful
Antagonistic Anger
150 Hate
Aggression
Denying
Disappointing Desire
125 Craving
Enslavement
Punitive
Frightening
Fear
100 Anxiety
Withdrawal
Disdainful
Tragic
Grief
75
Regret
Despondency
Condemning Hopeless
Apathy
50
Despair
Abdication
Vindictive
Evil
Guilt
30
Blame
Destruction
Despising
Miserable
Shame
20
Humiliation Elimination
POWER VS. FORCE David R. Hawkins, M.D.,Ph.D.
Marini 2004
Health
Interference
Patterns of Interference
Symptoms
Symptom
Constellations
Disease
Disease
Marini 2004
HEALTH CARE ERAS
Era I
Chemical, Mechanical, material or physical medicine
Described by being causal, deterministic, hierarchical, bound to classical
concepts of space-time. Mind is not a factor; mind is purely the result
of brain mechanisms.
Examples are any form of therapy focusing solely on the effects of
things (chemical or physical) on the body. Almost all forms of modern
allopathic-drugs, surgery, irradiation, etc.
Marini 2004
Era II
Mind-Body medicine. The role of energy/information on the physicalchemical body is embraced.
Described by the mind being a major factor in healing WITHIN the
single person; mind has causal powers. Healing not fully explainable by
classical concepts of science. Era 2 includes but goes beyond Era 1.
Examples are any therapy, which has the patient as the focus,
complementary approaches are incorporated. Therapies emphasizing
the effect of consciousness solely within the individual body:
psychoneuroimmunology, chiropractic, hypnosis, homeopathy,
acupuncture, biofeedback, relaxation therapies, therapeutic touch, and
imagery based therapies.
Marini 2004
Era III
Non-local therapy or Eternity Medicine
Described by the mind factoring into healing both WITHIN and
BETWEEN persons. Mind not completely localized to points in space
(brains or bodies) or time (present moment or single lifetimes). Mind
is unbounded in space and time and is ultimately unitary or one.
Distance healing possible. Not explainable by classical concepts of
space-time or matter-energy.
Examples are any therapy in which effects of consciousness bridge
between different persons: all forms of distant healing, intercessory
prayer, and transpersonal imagery.
DISEASES ARE SEEN AS IMBALANCES TO BE CORRECTED.
IMBALANCES AFFECT THE ENTIRE PERSON (BOTH THE PHYSICAL
BODY AND THE ENERGY BODY). IMBALANCES HAVE THE CAPACITY OF
AFFECTING THE INDIVIDUAL AS WELL AS THOSE LINKED BY ENERGY.
PROPER HEALING NECESSITATES BALANCING ENERGY AS WELL AS
CHEMISTRY AND STRUCTURE OF THE BODY. HEALTH AND HEALING
CAN BE AFFECTED BY ENERGY/INFORMATION FROM A DISTANCE.
PRAYER HAS BOTH A LOCAL AND NON-LOCAL EFFECT ON THE MINDMarini 2004
BODY.
HEALTH CARE ERAS
ERA I MEDICINE: Allopathic Therapies
Paradigm:
CHEMISTRY ↔ STRUCTURE ↔ FUNCTION
ERA II MEDICINE: Holistic/Holoenergetic Therapies
Paradigm:
ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION
Marini 2004
ERA III MEDICINE: Intercessory Therapies
Paradigm:
UNIFIED ↔ ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION FIELDS
Marini 2004