Transcript Document

• BAPI
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Bapineuzumab
'Bapineuzumab' is a humanized
monoclonal antibody that acts on the
nervous system and may have potential
therapeutic value for the treatment of
Alzheimer's disease and possibly
glaucoma
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Bapineuzumab
Bapineuzumab has been shown to
recognise the extreme N-terminal 5
residues of Aβ peptide in a helical
conformation (4HIX.pdb) stabilized by
internal hydrogen bonds involving the
first three amino acids.
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Bapineuzumab
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Bapineuzumab is an antibody to the betaamyloid (Aβ) plaques that are believed to
underlie Alzheimer's disease
neuropathology. In previous clinical trials
for vaccination against human beta
amyloid, called AN-1792, patients with
Alzheimer's disease using active
immunization had positive outcomes with
removal of plaques, but 6% of subjects
developed aseptic meningitis and the trial
was stopped.
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Bapineuzumab
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Bapineuzumab was being co-developed
by the pharmaceutical companies Élan
and Wyeth and entered Clinical
trial#Phase III|Phase III trials in
December 2007.
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Bapineuzumab
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In patients receiving the highest dose,
e.g. 2mg, MRI scans showed an
accumulation of water in brain tissue
(vasogenic edema). No health risks
were found in subjects receiving
either 0.5 or 1mg of bapineuzumab.
Patients who have been receiving or
have been scheduled to receive the
highest dose will be either removed
from the trials or switched to lower
doses.
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Bapineuzumab
On August 6, 2012, Pfizer Inc. and
Johnson Johnson said they are ending
development of an intravenous formulation
of bapineuzumab. Testing showed the
drug did not work better than placebo in
two late-stage trials in patients who had
mild to moderate Alzheimer's disease.
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Bapineuzumab
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Élan announced that Johnson Johnson,
on July 16, 2013, had discontinued Phase
2 testing of the Subcutaneous
injection|subcutaneous formulation of
bapineuzumab.[http://www.elan.com/comp
any/about_us Phase 2 testing of the
subcutaneous formulation of
bapineuzumab is to be discontinued.] Elan
Corporation. Retrieved 2013-08-13.
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Bapi Tutul
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'Bapi Tutul' are a Hindi film composer
duo consisting of Bapi and his younger
brother Tutul. They have written the
scores for films such as Sarkar
(film)|Sarkar Sarkar Raj, Khosla Ka
Ghosla and many more.
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Bapi Tutul - Early life
Bapi is known for his
specialization in Guitar
while Tutul in Piano
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Bapi Tutul - Connection with Music
Bapi and Tutul were hugely influenced by
their mother due to her interest in music.
Their initial training in Classical Music was
given by her. However, the quest to learn
western music brought the two brothers to
Mumbai. Here, they met Rodrcik Bismark and
learnt western music from him during 1994 till
1999. During this period, Bapi Tutul picked
up small music assignments like ad jingles
teaching music to students.
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Bapi Tutul - Discography
* Sarkar Raj
(2008).http://www.planetradiocity.com/mus
icreporter/celebrity-interviewdetails/Composer-duo-Bapi-Tutul-areback-with-Sarkar-Raj/138
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Bapi Tutul - Awards Accolades
Bapi-Tutul were nominated in the Best
Background Score Category for 15th Annual Star
Screen Awards
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Postalveolar - Point of tongue contact (laminal, apical, subapical)
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Apical and subapical articulations are
always tongue-up, with the tip of the
tongue above the teeth, while laminal
articulations are often tongue-down, with
the tip of the tongue behind the lower
teeth.
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Postalveolar - Point of tongue contact (laminal, apical, subapical)
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The upward curvature of the tongue
tip to make apical or subapical
contact renders palatalization more
difficult, so domed (palato-alveolar)
consonants are not attested with
subapical articulation, and fully
palatalized (e.g
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Postalveolar - Point of tongue contact (laminal, apical, subapical)
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Subapical retroflex sounds are often
palatal (and vice-versa); such sounds
occur particularly in the Dravidian
languages
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