Transcript Efficacy of a PEG/PG based Ocular Lubricant to Reduce Transient

Efficacy of a PEG/PG based Ocular
Lubricant to Reduce Transient
Visual Degradation
Rolando Toyos, M.D.
Whitney Hauser, O.D.
The author of this poster has received research funding from Alcon
Laboratories.
Rolando Toyos, M.D.
• Medical Director and Founder
of Toyos Clinic,
Memphis, Tennessee.
• President of The Sports
Ophthalmology Society of
America
• Team Ophthalmologist for the
Memphis Grizzlies
Whitney Hauser, O.D.
• Clinical Director, Toyos Clinic,
Memphis, Tennessee.
• Adjunct Faculty member,
Southern College of Optometry.
• Center Director, TLC Laser Eye
Centers, Memphis, Tennessee.
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• The forced stare mimics
activities such as:
▫ Driving a car
▫ Flying a plane
▫ Playing certain sports (i.e.
baseball)
The forced stare is used to
measure visual degradation, a
factor related to dynamic
visual acuity.
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• Prospective, open-label, single-arm, single
center study
• 30 subjects enrolled
• Eligibility requirements
▫ Bilateral BCVA = 20/20
▫ History of episodic Dry Eye
▫ Minimum TBUT = 10 seconds at baseline
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• Subjects stared at Landolt E (adjusted to 20/20)
at a distance of 60 feet and 6 inches without
blinking and reported when target was unclear
• Visual degradation measured:
▫ Before drop instillation of PEG/PG based
lubricant
▫ 5 minutes after instillation of PEG/PG based
lubricant
Endpoint = Change in subject-reported clear vision
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• Mean Clear Vision (MCV) duration = 6.46
seconds (± 3.00 seconds) before instillation
• MCV duration = 8.32 seconds (±3.86 seconds)
after bilateral instillation of lubricant
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• Instillation of the PEG/PG based Ocular
Lubricant significantly increased MCV duration
• Improvement was observed in 26 of 30 subjects
(87%)
• Mean Increase = 2.22 seconds
• Maximal MCV = 7.6 seconds
The Effect of the PEG/PG based
Ocular Lubricant on Forced Stare
• 4 subjects observed a decreased duration of
MCV post-treatment
• Mean Decrease = 0.54 seconds
• No adverse events were reported for this study
Conclusion
• Bilateral acute administration of PEG/PG ocular
lubricant reduced visual degradation in these
patients, suggesting an improvement in tear film
stablilization.
• These results warrant further study of PEG/PG
ocular lubricant use to improve dynamic visual
acuity which is important in sports such as
baseball and other activities like flying and
driving.