Transcript Intraocular Pressure After Phacoemulsification in

Intraocular Pressure After
Phacoemulsification in
Psuedoexfoliation Patients
Mai Pham MD, Sarosh Janjua MD, Jannet Ung MD,
Sandra Cremers MD FACS
Massachusetts Eye and Ear Infirmary
Harvard Medical School
Purpose
To determine whether phacoemulsification
leads to a greater drop in intraocular
pressure (IOP) in psuedoexfoliation (PXF)
patients as compared to nonpseudoexfoliation patients.
Methods
In a retrospective cohort study, a large database of
phacoemulsifications performed by residents was used
to recruit patients in two groups: those with PXF (86
patients) and those without (113 patients).
Exclusion criteria included history of glaucoma,
diabetes, intraocular hypertension, and previous ocular
surgery.
Intraocular pressures were noted at baseline, then at
1 day, 1 week, 1 month, 6-9 months, 12 months and 24
months following phacoemulsification.
The data was then analyzed using STATA version 9.
Results
Intraocular pressures in both groups were
significantly lower than the pre-operative baseline
throughout the follow-up period of 24 months.
There was no significant difference in the drop in
intraocular pressures between the two groups.
Compared to their pre-operative baselines, PXF
patients had significantly lower IOP at 3 months
(p=0.03), 6-9 months (p <0.01), 12 months (p <0.01) and
24 months (p <0.01).
Non-PXF patients also had significantly lower IOPs
compared to their pre-operative baseline at 1 month (p =
0.028) and each time point thereafter (all p <0.01).
Changes in IOP Between PXF Patients and Controls From Preop to 24 Months
24
Intraocular Pressure (mmHg)
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PXF
Controls
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p = 0.62, comparison of slopes
F-test, repeated-measures ANOVA
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Baseline
1 Day
1 Week
1 Mo
3 Mo
Follow-up
6-9 Mo
12 Mo
24 Mo
Conclusion
Phacoemulsification does not lead to a
significantly greater drop in intraocular
pressure in pseudoexfoliation patients as
compared to non-pseudoexfoliation
patients.
There is a significant drop in intraocular
pressures in both groups compared to
their baseline pre-operative pressures.
Financial Disclosures
None