Transcript Effect Of Androgens On Bone Mineral Density In Saudi

Effect Of Androgens On Bone Mineral Density In Saudi Arabian
Males
Above The Age Of 50 Years
Sadat-Ali, M; Alelq, AH
SAUDI MED J, SAUDI MEDICAL JOURNAL; pp: 1247-1250; Vol: 28
King Fahd University of Petroleum & Minerals
http://www.kfupm.edu.sa
Summary
Objective: To test the effect of sex steroids on the development of osteoporosis in
male Saudi Arabs above the age of 50 years. Methods: Male Saudi patients over the
age of 50 years, attending the outpatient clinics between May 2005 and January 2006
of King Fahd Hospital of the University, Al-Kbobar, Kingdom of Saudi Arabia,
comprised the study subjects. Patient's body mass index was calculated, and
investigations were performed to rule out secondary osteoporosis. Blood was
extracted for serum level of androgens, gonadotropins, and thyroid stimulating
hormone, albumin, calcium, phosphorus, and alkaline phosphatase. Bone mineral
density measurement of hip and spine was carried out using dual energy x-ray
absorptiometry. Osteopenia and osteoporosis were defined per the World Health
Organization description. Results: We analyzed the data of 181 patients with an
average age of 61.76 +/- 0.75. Ninety-nine (54.7%) were osteopenic (Group B) and 54
(29.8%) were osteoporotic (Group Q. Osteoporotic patients (Group C) had a higher
testosterone level, 486.85ng/dl +/- 17.18 versus 424.84ng/dl +/- 20.93; p=0.001, and
lower estradiol levels, 22.3pg/ml +/- 0.73 versus 28.55pg/ml +/- 1.82,p=0.001,
compared to the non-osteoporotic patients (Group A). Compared to the nonosteoporotic group, the osteopenic patients had higher levels of testosterone (p=0.05)
and lower estradiol levels (p=0.001). Conclusions: Our study indicates that serum
levels of testosterone in Saudi Arabian males of over 50 years have little influence on
the protection against the development of osteoporosis and osteopenia, and secondly
males who have a low level of estradiol are more likely to have low bone mineral
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Copyright: King Fahd University of Petroleum & Minerals;
http://www.kfupm.edu.sa
density, osteopenia, or osteoporosis.
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Copyright: King Fahd University of Petroleum & Minerals;
http://www.kfupm.edu.sa