Transcript The Cochrane Collaboration

Finola Delamere,
Managing Editor
at the editorial base of the
Cochrane Skin Group
www.skin.cochrane.org
Centre of Evidence Based Dermatology (CEBD)
Nottingham, UK
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Cochrane
&
the
Cochrane Skin Group
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Rationale for Cochrane

Collective ignorance about effects of healthcare

Overwhelming amount of clinical information

A systematic approach needed to organising
and evaluating clinical trial data

The Cochrane systematic review
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What is Cochrane?

It is an international organisation of individuals who
write & publish Cochrane systematic reviews

It prepares and maintains the Cochrane Library
which is published online

It is the principle source of up-to-date high quality
evidence on the effects of healthcare interventions
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International Cochrane Centres
Canadian
Nordic
German
UK
Dutch
French
Iberoamerican
Italian
Chinese
US
South Asian
Brazilian
South
African
Australasian
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Cochrane - structure
Cochrane
skin group
editorial base
& the French
satellite
52 Editorial
Review
Groups
10 Fields
&
networks
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International
Centres
Steering
Group &
Central
Editorial Unit
17 Methods
Groups
The
Consumer
Network
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Why ‘Cochrane’ ?

Archie Cochrane, a British epidemiologist, pointed out the
deficiencies of current reviews of the medical literature in
Cochrane AL (1972). 'Effectiveness and Efficiency: random
reflections on health services'.

Iain Chalmers - an obstetrician. The first ‘Cochrane Centre’
opened in Oxford 1992.
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What makes a Cochrane review?
 Structured






process involving several steps
Well formulated question
Team effort
Comprehensive data search
Unbiased selection and abstraction process
Critical appraisal of data
Synthesis of data
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Stages of a Cochrane Review
 Submit
 Write
 Write
a title-the idea
the protocol-the plan
the review-the product
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Intervention reviews published
2015

Oral fumaric acid esters for psoriasis (#90)
 Anti-TNF agents for paediatric psoriasis (#137)

House dust mite reduction and avoidance measures
for treating eczema (#130)
 Topical tacrolimus for atopic dermatitis (#69)
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

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


Complementary therapies for acne vulgaris (#110)
Interventions for hirsutism (excluding laser and
photoepilation therapy alone) (#142)
Topical antifungals for seborrhoeic dermatitis (#120)
Sentinel lymph node biopsy followed by lymph node
dissection for localised primary cutaneous melanoma
(#126)
Interventions for prevention of herpes simplex
labialis (cold sores on the lips) (#92)
Interventions for hidradenitis suppurativa (#81)
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Updated reviews
 Interventions
for vitiligo (#24)
 Interventions
for rosacea (#25)
 Safety
of topical corticosteroids in pregnancy
(#119)
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Protocols
 Systemic
pharmacological treatments for
chronic plaque psoriasis (#156)
 Interventions for guttate psoriasis (#02)
 Antistreptococcal interventions for guttate and
chronic plaque psoriasis (#16)
 Interventions for chronic palmoplantar
pustulosis (#06)
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 Interventions
for necrotizing soft tissue
infections in adults (#158)
 Indoor salt water baths followed by artificial
ultraviolet B light for chronic plaque psoriasis
(#117)
 Effects of systemic immunosuppressive
therapies for moderate-to-severe eczema in
children and adults (#154)
 Interventions for acne scars (#14)
 Lifestyle changes for treating psoriasis (#161)
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Diagnostic Test Accuracy reviews
 Tests
to assist in the diagnosis of cutaneous
melanoma in adults: a generic protocol (#164)
 Tests
to assist in the diagnosis of keratinocyte
skin cancers in adults: a generic protocol
(#165)
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Life after publication
strategy –to each review team
 Co-publications- in BJD; JAAD
 Podcasts – the Oral evening primrose oil and
borage oil for eczema was podcasted in 13
different languages!
 Blogs – by Knowledge Broker, Cochrane UK
 CEBD sends out monthly evidence updates to
derm community
 Guidelines- mixed success
 Dissemination
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Skin Group reviews used in guidelines in
UK, USA, Canada & by WHO
 Interventions
for bullous pemphigoid
 Topical treatments for chronic plaque psoriasis
 Interventions for alopecia areata
 Topical antifungal treatments for tinea cruris
and tinea corporis
 Interventions to reduce Staphylococcus
aureus in the management of atopic eczema
 Surgical excision margins for primary
cutaneous melanoma.
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