Transcript HYALURONIC ACID

Vojtěch Kupka
Brno, University of Technology,
Faculty of Chemistry
HYALURONIC ACID
DISCOVERY
1934 - Karl Meyer and his assistant John Palmer isolated
new glykoaminoglycane from the vitreous humour of
bovine eyes
vitreous humour – sklivec
bovine – hovězí, kravský
ETYMOLOGY
-hyalos (Greek for vitreous)
-uronic acid (possesses high content of uronic acid)
STRUCTURE
-it consists of repeating disacharides units
D-N-acetylglucosamine
b-D-glucuronic acid
-the units are joined with repeating beta-1,4 and beta-1,3
glycosidic bonds
OCCURENCE AND
PHYSIOLOGICAL IMPORTANCE
-in the skin (about 50 % of the total hyaluronan in the body)
-the vitreous humour of the eye
-in the synovial fluid (3-4 mg/ml)
-in the matrix around the oocyt during ovulation
(~0,5 mg/ml)
-in some situations rapid increase
(shock incidents, wound healing, septicaemia)
synovial fluid - kloubní maz
wound healing – hojení ran
septicaemia – otrava krve
USE
- in the late fifties hyaluronan was applied for
the first time to humans - as vitreous humour
replacement during eye surgery
- hyaluronan improves properties of synovia
silences pain in joints
surgery – operace, chirurgie
joint - kloub
and
- for healthy and fresh skin
- to improve the effectiveness of
local anaesthesia
- to prevent tissue destruction
- hyaluronates are widely used in
many branches of medicine like
orthopaedia, surgery,
ophthalmology, oncology,
dermatology, gynaecology
- may have anticancer effects and can suppress tumour
progression, however, the findings are rather inconsistent
suppress – potlačovat
tumour – nádor, otok, zduření
- in plastic surgery (Restylane) – for bigger an better lips
before
after
THANK YOU FOR YOUR ATTENTION