Transcript LAB 7
بسم هللا الرحمن الرحيم Medical Mycology Lab 7 Fungal infections - mycoses Types of Mycoses Fungal infection in or on any part of animales or humen body. (adisease caused by fungi) 1- Superficial affects only Outer skin layer /hair/nails** does not extend to tissues no immune response, caused mostly by yeasts (Dandruff) Dalia Al Sarar • Tinea versicolor (= Pityriasis versicolor) Caused by Malassezia furfur – Normal flora of skin and scalp The main symptom is patches of discolored skin with sharp borders (edges). The patches are often dark reddish-tan in color. in the back, underarms, upper arms, chest, and neck Dalia Al Sarar 2- cutaneous = Dermatophytosis extend deeper into epidermas ,the organism that cause these disease called dermatophytes. dermatophytes Groupe of tree type of fungus causes skin disease These genera are Microsporum,epidermophyton,trichoptyton And ther are 40 species in these three genera. 3- sub cutaneous under skin; infection grows primarily within the dermis, sometimes later extending to nearby muscle and bone 3-Systemic internal organs, lungs, bloodstream, internal mucous membranes (e.g., mouth, genitourinary tract, large intestine)Mostly originating in the lung caused by virulent dimorphic fungi Dalia Al Sarar Examples of Mycoses Tinea Tinea is the name of a group of diseases caused by a fungus Clinical classification based on location: •Tinea pedis Athlete's foot causes itching and flaking , burning and cracked skin between toes Dalia Al Sarar • Tinea cruris – Starts in groin area causes an itchy, burning rash (“Jock itch”) – Causes by Trychophytun rubrum Dalia Al Sarar •Tinea corporis Ringworm is a red skin rash that forms a ring around normal-looking skin on the arms, legs, face, or other body areas. Dalia Al Sarar Dalia Al Sarar Tinea barbae Tinea barbæ (also known as "Barber's • itch,""Ringworm of the beard,". Tinea barbae is due to a dermatophytic infection around the bearded area of men. Dalia Al Sarar Dalia Al Sarar diagnoses •it can diagnose Athlete's foot simply by looking at skin. If tests are needed, they may include: Microscopic test 40-70% of infection identifies by this techiniqe. •Skin culture test •Skin lesion biopsy •Skin lesion KOH exam it can often diagnose tinea corporis by how the skin looks.In some cases, the following tests may be done: •Looking at a skin scraping of the rash under the microscope using a KOH (potassium hydroxide) test •Skin lesion biopsy A skin scraping that is examined under a microscope should show the yeast. A drop of potassium hydroxide is applied to a small scraping of involved skin which is then examined under the microscope it can usually diagnose jock itch based on how skin looks. Tests are usually not necessary. If tests are needed to confirm the diagnosis, either a culture or a skin lesion biopsy (for example, a scraping of the skin) may be done. A KOH (potassium hydroxide) test Dalia Al Sarar Treatment Treatment requires both systemic oral treatment with most of the same drugs used in humans— terbinafine, fluconazole, or itraconazole—as well as topical "dip" therapy. Most tinea corporis, cruris, and pedis infections can be treated with topical agents. Consideration should be given to systemic treatment when lesions covering a large body [email protected] Dalia Al Sarar