Transcript 1 - Researchmap

Instrumental learning (acquisition + performance)
posterior
Goal-directed action
(action-outcome association)
Habit
(stimulus-response connection)
anterior
No direct evidence of plasticity in the pDMS related
to A-O learning has been reported.
--measuring pERK using immunohistochem.
--ex-vivo patch clamp electrophysiological recording
Basal ganglia circuitry
Cortex
D2R+
Indirect path
Enkepharin+
A2AR+
Inhibitory
GABAergic
neurons and
projections
STN
GPe
D1R+
Substance P+,
Dynorphin+
A1R+
Direct path
Excitatory
glutamatergic
neurons and
projections
SNｒ/GPi
Striatum
(medium spiny
neurons)
Result 1: Goal-directed learning increases activity
in D1R+ MSN in dorsomedial striatum
Result 1: Goal-directed learning increases activity
in D1R+ MSN in dorsomedial striatum
--the change in pERK might reflect higher activity in the
trained mice?
--the change in pERK might reflect a temporary change in
neuronal activity associated with performance rather than
acquisition?
Result 2: Opposing synaptic plasticity in the D1R+ and
D2R+ MSNs is induced by goal-directed learning in
dorsomedial striatum
Result 2: Opposing synaptic plasticity in the D1R+ and
D2R+ MSNs is induced by goal-directed learning in
dorsomedial striatum
GCaMP3 fluorescence transients in both direct- and indirect
pathway neurons during action initiation in an operant task
Summary
[D1+ MSNs]
Goal-directed
learning
pERK (/and) AMPA↑  LTP
[D2+ MSNs]
AMPA↓  LTD
The striatum is biased against allowing cognitive states rapidly to elicit
action after/during goal-directed learning
In untrained animals, inhibition of functional output from pDMS?