Transcript Functional Human Physiology for the Exercise and Sport Sciences

Functional Human Physiology
for the Exercise and Sport Sciences
Synaptic Transmission and Neural Integration
Jennifer L. Doherty, MS, ATC
Department of Health, Physical Education, and
Recreation
Florida International University
Types of synapses
 Electrical Synapses
 Nerve impulse transmission directly from one
neuron to another through membranes
connected by gap junctions
 No neurotransmitters
 Chemical Synapses
 Nerve impulse is transmitted from one neuron to
another across a synapse
1) A region of functional contact (not actual contact) with
another neuron
2) Specialized to release and receive neurotransmitters
Chemical Synapses – Functional
Anatomy
 Neuron-to-Neuron Synapses
 Close junction between the axon terminal of one
neuron and the plasma membrane of another
neuron
 Presynaptic Neuron
 At a synapse, a neuron that transmits signals to
a second neuron
 Communicates with a post-synaptic neuron
through the axon
Chemical Synapses – Functional
Anatomy
 Synaptic Knob (Bouton)
 The rounded terminal end of the axon on a
presynaptic neuron
 Many synaptic knobs of many axons may
terminate on the cell body or dendrites of
postsynaptic neurons.
 Contains many mitochondria
 Contains Synaptic Vesicles
1) Store neurotransmitters
Chemical Synapses – Functional
Anatomy
 Synaptic Vesicles
 Release neurotransmitters to diffuse across the
synaptic cleft
 Neurotransmitters attach to receptors on the
post-synaptic neuron cell membrane
 Synaptic cleft
 Narrow, fluid-filled space between presynaptic
and post-synaptic neurons
1) 30 - 50 nm or 1 millionth of an inch wide
 No direct contact between neurons.
Chemical Synapses – Functional
Anatomy
 Post-synaptic neuron
 At a synapse, the neuron that receives signals
from another neuron
 Post-synaptic membrane
1) Contains neurotransmitter receptors
 Specialized protein receptors that react with (or receive) a
specified neurotransmitter
Signal Transduction – Nerve
Impulses (Wave of Action Potentials)
 Presynaptic Neuron Signal Transduction

A wave of action potentials are propagated along the
cell membrane of the presynaptic axon
The wave of action potentials arrive at the synaptic
knob.



Ca++ voltage-gated channels in the synaptic knob open in
response to depolarization of the cell membrane
Ca++ ions from the extracellular fluid enter the synaptic knob
Signal Transduction – Nerve
Impulses (Wave of Action Potentials)
 Increased amounts of intracellular Ca++ ions
1) Causes the synaptic vesicles to move toward and fuse with
the membrane of the synaptic knob
2) The synaptic vesicles release neurotransmitters into the
synaptic cleft via exocytosis
 Unless another action potential is present…
1) The Ca++ voltage-gated channels close
2) Ca++ is actively transported out of the synaptic knob.
Signal Transduction – Nerve
Impulses (Wave of Action Potentials)
 Synaptic Cleft
 Neurotransmitters diffuse across the synaptic cleft

Transmission of a nerve impulse across the synaptic cleft can
only occur in one direction
 Neurotransmitters bind to specific protein
receptors on the post-synaptic membrane

Produces a response on the post-synaptic neuron
 Neurotransmitters are quickly removed from the
protein receptors by:



Degradation by specific enzymes,
Diffusing away from the synapse, or
Reuptake by neuroglial cells or the presynaptic neuron
Signal Transduction – Nerve
Impulses (Wave of Action Potentials)
 Post-Synaptic Signal Transduction
 Neurotransmitters bind to specific protein
receptors on the post-synaptic membrane
 Ion channels on the post-synaptic membrane
open
 Results in a change of the membrane potential
of the post-synaptic neuron
1) Depolarization occurs
2) Results in a wave of action potentials that is propagated
along the cell membrane of the post-synaptic neuron
Signal Transduction – Nerve
Impulses (Wave of Action Potentials)
 Rarely is only one neuron responsible for
producing an action potential on the cell
membrane of another neuron
 Several neurons must produce enough graded
potentials to reach the “threshold” for generating an
action potential
 Two determinants of signal transduction:
1) The type of neurotransmitter, and
2) The receptor proteins
 Result is either
1) Excitation (depolarization), or
2) Inhibition (hyperpolarization)
Excitatory Synapses
 Bring the membrane potential closer to the
threshold for generating an action potential
 Excitatory neurotransmitters depolarize the postsynaptic membrane
 This is called an Excitatory Postsynaptic Potential
(EPSP)
 Opens Na++ voltage-gated channels on the postsynaptic membrane allowing Na++ ions to enter
the cell
1) Fast response occurs via Ionotropic receptors
 Channel-linked receptors
2) Slow response occurs via Metabotropic receptors
 G-protein linked receptors
Inhibitory Synapses
 Bring the membrane potential away from
the threshold for generating an action
potential
 Inhibitory neurotransmitters hyperpolarize or
stabilize the post-synaptic membrane
 This is called an Inhibitory Postsynaptic
Potential (IPSP)
 Opens K+ voltage-gated channels on the
post-synaptic membrane allowing K+ ions to
leave the cell
Neural Integration
 The net effect of EPSPs and IPSPs on the
post-synaptic membrane will determine if
the net effect is excitatory or inhibitory.
 If the net effect is more excitatory than
inhibitory, an action potential will be
generated on the post-synaptic membrane
and impulse transduction will occur
 The opposite is also true, a net inhibitory
effect will not produce an action potential.
Neurotransmitters

Structure


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Chemical compounds
Over 30 different types of neurotransmitters
Major categories include:
1)
2)
3)
4)

Choline derivatives
Biogenic amines
Amino acids
Neuropeptides
Synthesis



Neurotransmitters are synthesized in the cytoplasm of the nerve
cell body or the synaptic knob
Neurotransmitters are stored in the synaptic vesicles
More than one neurotransmitter may be produced by a neuron
Acetylcholine (ACh)


Choline derivative neurotransmitter
Found at the neuromuscular junction predominantly

Responsible for stimulating muscles to contract

Acetylcholinesterase
 Enzyme that degrades ACh into acetate and choline
 Acetylcholine Receptors
 Nicotinic cholinergic receptors
1) Excitatory
2) Found on skeletal muscles (somatic nervous system) and in neurons
in the autonomic nervous system

Muscarinic cholinergic receptors
1) Either excitatory or inhibitory
2) Found in the central nervous system
Biogenic Amines – Neurotransmitters
derived from Amino Acids

Catecholamines
 Includes the neurotransmitters:
1) Norepinephrine (NorE)
2) Epinephrine (Epi)
3) Dopamine

Important in many of the motor functions of the autonomic
nervous system
 Serotonin
 Found in brainstem
 Regulates sleep and emotions
 Histamine
 Found in hypothalamus
 Better known for release from tissue cells in inflammatory
response
Biogenic Amines – Neurotransmitters
derived from Amino Acids
 Adrenergic receptors
 Alpha adrenergic
1) Norepinephrine mostly, but binds to both
 Beta adrenergic
1) Epinephrine mostly, but binds to both
 Degradation enzymes:
 Monoamine oxidase (MAO)
 Catechol-O-methyltransferase (COMT)
Amino Acid Neurotransmitters
 Most abundant class of neurotransmitters
 Function only in the central nervous system
 Excitatory neurotransmitters
 Glutamate
 Aspartate
 Inhibitory neurotransmitters
 Glycine
 Gamma-aminobutyric acid (GABA)
Neuropeptides

Short chains of amino acids that function as neuromodulators
 A neuromodulator is a substance that alters the response of a
neuron to a neurotransmitter, or it blocks the release of a certain
neurotransmitter.
 Neuropeptides are more classically known as hormones
 Examples:
 TRH = regulates the release of TSH
 Substance P = decreases gastrointestinal motility
 Vasopressin = regulates urine output by the kidneys
 Endogenous opiates = analgesic effect, euphoric response
1)
2)
Enkaphalins
Endorphis