Transcript Bio 449 Lecture 3 Outline Aug. 30, 2008

Bio 449
Lecture 10 - Sensory Physiology II
General mechanisms (cont’d)
Receptive field size
Lateral inhibition
Chemoreception - taste and smell
Gustation
Olfaction
Terms to Know
Receptive field size
Lateral inhibition
Gustation
Taste bud
Taste receptor cell
Umami
Gustducin
Tastant
Olfaction
Olfactory receptor cell
Olfactory epithelium
Olfactory bulb
Odorant
Readings
Lectures 10 & 11: Chapter 10, pages 349-379
Lectures 12-14:
Chapters 6 & 7
Sep. 17, 2010
Receptive Field Size
(b)
(a)
Compass with points
separated by 20 mm
Skin surface
Skin surface
Primary
sensory
neurons
Secondary
sensory
neurons
One signal goes to the brain.
Fig. 10-3
Two signals go to the brain.
Gustation
Sweet
Umami
Bitter
Salty or sour
Tight junction
Support cell
Taste pore
Presynaptic
cell
ATP
Serotonin
Receptor cells
Primary gustatory
neurons
Fig. 10-16
Taste Bud
Taste Transduction
1
Gustducin
Sweet, umami,
or bitter ligand
Salt
Sour
Na+
H+
1
GPCR
2
1
Na+ 2
H+ 2
Signal
transduction
Cell
depolarizes
Ca2+
Ca2+
3
3
? ?
Ca2+
Ca2+ 3
Ca2+
Ca2+
?
ATP
Serotonin
4
4
4
Primary gustatory
neurons
Fig. 10-17
5
5
5
Receptor A
Receptor B
Receptor C
Receptor D
Olfaction
Olfactory
bulb
Olfactory
epithelium
Fig. 10-14
Olfactory
tract
Brain
Olfaction
Olfactory bulb
Glomeruli
Mitral cells
To limbic system
and cerebral cortex
Bone
Cilia
Olfactory receptors
Olfactory Receptors
Developing olfactory cell
Olfactory receptor cell
Supporting cell
Olfactory cilia
Mucus layer
Fig. 10-14
Touch Receptors
Merkel receptors
Hair
Meissner’s corpuscle
Free nerve
ending
Hair root
Sensory nerves
Pacinian corpuscle
Ruffini corpuscle
Fig. 10-11