Transcript Slide 1 - AccessPharmacy

Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells
differentiates under the influence of specific hematopoietic growth factors to form a variety of hematopoietic and lymphopoietic cells. Stem cell factor
(SCF), FTl- 3 ligand (FL), interleukin-3 (Il- 3), and granulocyte/macrophage colony-stimulating factor (GM-CSF), together with cell–cell interactions in the
marrow, stimulate stem cells to form a series of burst-forming units (BFU) and colony-forming units (CFU): CFU-GEMM, CFU-GM, CFU-Meg, BFU-E, and
CFU-E (GEMM, granulocyte, erythrocyte, monocyte, and megakaryocytes; GM, granulocyte and macrophage; Meg, megakaryocyte; E, erythrocyte). After
considerable proliferation, further differentiation is stimulated by synergistic interactions with growth factors for each of the major cell lines–granulocyte
Source: Chapter 135. Cancer Treatment and Chemotherapy, Pharmacotherapy: A Pathophysiologic Approach, 8e
colony-stimulating factor (G-CSF), monocyte/macrophage-stimulating factor (M-CSF), thrombopoietin, and erythropoietin. Each of these factors also
Citation:
DiPiro JT,
Talbert RL,
YeeinGC,
Matzke
GR,the
Wells
BG, Posey
L. Pharmacotherapy:
Pathophysiologic
Approach, 8e;
2011Kipps
Available
influences the
proliferation,
maturation,
and,
some
cases,
function
of the
derivative cell line.A (Adapted
from Kaushansky
K and
TJ.
at:
http://mhmedical.com/
Accessed:
March
30,
2017
Hematopoietic agents: Growth factors, minerals and vitamins. In: Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman’s The Pharmacologic Basis of
© 2017
McGraw-Hill
Education.
All rights reserved
Therapeutics,Copyright
11th ed. New
York:
McGraw-Hill,
2006: 1435.)