Transcript Developing magnetic resonance-based in

Developing magnetic resonancebased in-line sensors
Michael J. McCarthy
Department of Food Science
& Technology
NMR and MRI
Strengths
- Chemical identification
- Structure determination
- Medical imaging
- Microscopy imaging
- Noninvasive
- High speed…
Current Limitations:
Not suitable for industrial environment
Not portable
Low sensitivity
http://www.bruker-biospin.com/nmr_magnets_us2.html?&L=0&print=
Strawberry Milk
Chocolate Milk
4 Averages
Chocolate Milk
20 Averages
Goals of our NMR work
• Address current limitations and enable process
NMR/MRI spectrometers for in-line control
– Compatible with operation in an industrial
environment
• Small side streams
• Larger installations for 100 % inspection
– Rapid measurements of
• Composition / quality attributes
• Structure / Particle size, Rheological
properties
– Compatible with fluid food processing
• Clean in place chemical
• Liquid and particulate suspensions
Enabling process NMR/MRI
• Engineered materials
– Novel magnets
• Aspect AI
• ABQMR Inc.
• Miniaturization – NeSSI
compatible
– Microfabricated components
– Dynamic nuclear polarization
• Measurement information
processing
– Artificial intelligence, neural networks,
chemometric methods
2 T MRI system
Magnet Design Options
• Higher magnetic field (~1.0 T)
– Advantages
1 Tesla; ~0.4 sec scan
• Signal-to-noise! (high speed)
– Disadvantages
• Cost
• Weight
– Imaging/nonimaging options
• Low magnetic field strength (~0.05 to 0.2 T)
– Advantages
• Cost
• Easier to integrate
– Disadvantages
• Signal-to-noise ratio (limits speed)
– Imaging and/or nonimaging
0.1 T; 8 hour scan
High Field System – Industrial System 1.0 Tesla
No external field
Industrial grade
Large volume
1 Tesla Field Strength
High performance
Photos courtesy of ASPeCT Magnet Technologies Ltd.
www.aspect-mr.com
Example: Seed Detection
1. Turbo Flash
2. FSE
Tomato concentrate viscosity to
ketchup viscosity
1 (6 ounce) can tomato paste with garlic
1/2 cup light corn syrup
1/4 cup white vinegar
1/4 cup white balsamic vinegar
1/4 cup water
1 tablespoon sugar
1 teaspoon salt
1/4 teaspoon onion powder
Measure tomato concentrate rheology
Tomato ketchup Bostwick (cm)
Correlation of Ketchup Bostwick using in-line viscosity
measurements of 12 Brix Tomato Concentrate
10.00
9.00
8.00
ntss 6
7.00
ntss 7
6.00
ntss 8
5.00
Linear (ntss 6)
4.00
Linear (ntss 7)
3.00
Linear (ntss 8)
2.00
1.00
0.00
1.000
1.200
1.400
1.600
1.800
2.000
Tomato Concentrate (Viscosity/density)(-1/5)
Portable low-field magnet
Single-sided design
10.2 cm diameter
5.0 cm high
3.0 kilograms
Proton frequency 5.2 MHz
Measurement at 20 mm depth into melon
(alternate designs yield up to 50 mm depth)
Personal size watermelon
13
data1
linear
12.5
12
Brix =-0.015 X +21
Photo courtesy of ABQMR, Inc
Degrees Brix
11.5
11
10.5
10
9.5
9
8.5
550
600
650
700
Spin spin relaxation time, ms
750
800
Miniaturization
micro-NMR Incorporate DNP



Low field NMR Spectra
Benchtop/portable spectroscopy
 Labscale system for
metabolomics measurements
Microscale rheology
DNP 110x to 200x
Signal Enhancement
x100
Advanced in-line sensors for sorting fruit
Using a Partial Least Squares-Discriminant Analysis applied to MRI data it is predicted that yields for the
process can be increased by approximately 10%
Good
Whole
Peel Pack
Paste Production
Sunburn
Byproducts
Rot
Magnetic Resonance Imaging
Summary
• Novel permanent magnet
designs extend applications
of NMR/MRI from laboratory
to the production line.
• Microfabricated components
are NeSSI scale compatible.
• Permits quantitative quality
standards and process
control.
Acknowledgements
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Rebecca Milczarek
Boaz Zion
Paul Chen
Sandra Garcia
Songi Han
Jeffrey Walton
Eiichi Fukushima,
ABQMR, Inc.
• Uri Rapoport, ASPECT
Magnet Technologies Ltd.
www.aspect-mr.com
• USDA
• USDA-BARD
• CDFA
• Citrus Research Board
• Avocado Commission
• ConAgra Foods
• Paramount Citrus
Association
• CPAC