Transcript The Burden of Common Preventable Chronic Diseases

Scientists couldn't believe it at first, but now
they've been forced to admit:
#1. Inflammation causes hardening of the
arteries. It makes cholesterol stick to your
artery walls in thick deposits called plaque, and
then...
#2. Inflammation causes heart attacks! It
tears off pieces of artery plaque and sends them
hurtling toward your heart, or worse...
#3. Inflammation causes strokes when those
chunks of plaque reach your brain and...
#4. Inflammation may even cause 9 out of 10
cases of high blood pressure!
The Burden of Common
Preventable Chronic
Diseases
70% to 90% of deaths from chronic illnesses in the
U.S. are believed to be caused by poor nutrition, sedentary
living, and tobacco use.
In addition to hypertension, manifestations of the
lifestyle syndrome include the metabolic syndrome,
obesity, dyslipidemia, CVD, cancer, osteoarthritis,
depression, sexual dysfunction, and type 2 diabetes
mellitus.
6
“According to a case-controlled study of 52 countries (INTER-HEART), optimization of 9
easily measured and potentially modifiable risk factors could result in a 90
percent
reduction in risk of an initial acute myocardial infarction. The effect of these risk
factors is consistent in men and women across different geographic regions by ethnic
group, which makes study applicable worldwide.
These 9 risk factors included
Cigarette smoking,
Abnormal blood lipid levels,
Hypertension,
Diabetes,
Abdominal obesity,
a Lack of physical activity,
Low daily fruit and vegetable consumption,
Alcohol over consumption
and STRESS.”
All nine of the risk factors have 1 common
denominator: INFLAMMATION!!!
Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics – 2008 update: a report from the
American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008 Jan
29;117(4):e25-146.
Researchers indicate systemic
inflammation promotes insulin
resistance leading to
Metabolic Syndrome.
“Evidence at present favors
chronic inflammation as a
trigger for chronic insulin
insensitivity, rather than the
reverse situation.”
Grimble RF. Inflammatory status and insulin resistance. Currr Opin Clin NutrMetab Care 2002;5(5):551-9.
From:
AHA / NHLBI Scientific Statement
“Diagnosis and Management of the Metabolic Syndrome”
An American Heart Association /
National Heart, Lung, Blood Institute Scientific Statement
The NCEP
ATP
III
proposed a simple set of diagnostic criteria:
 Waist circumference
 Triglycerides
 HDL-Cholesterol
 Blood pressure
 Fasting glucose level
Abnormalities in any 3 of these 5 measures
constitutes a diagnosis of metabolic syndrome.
(National Cholesterol Education Program)
(Adult Rx Panel)
Circulation 2005;112:000-000 @www.circulationaha.org
From:
AHA / NHLBI Scientific Statement
“Diagnosis and Management of the Metabolic Syndrome”
An American Heart Association /
National Heart, Lung, Blood Institute Scientific Statement
Metabolic Syndrome confers:
 A 2-fold increase in relative risk for ASCVD events.
 A 5-fold increase in risk for developing DM-II in
individuals without established diabetes.
“This finding implies that the metabolic syndrome
imparts a relatively high long-term risk for both
ASCVD and diabetes.”
Circulation 2005;112:000-000 @www.circulationaha.org
Belly Fat causes Excess Estrogen in Men!!!
Abdominal Fat increases risk of: Stroke, Cancer, CVD
Correlation
between
Estradiol and
Inflammation
The epidemic
of abdominal
obesity
observed in aging men
How Excess Estrogen Levels Occur in Aging Men
In males, the main biologically active estrogen is estradiol. The primary source of estradiol in men is from the
conversion (aromatization) of testosterone. As men age, the production of androgens from the adrenals and
gonads is decreased. The aromatization of testosterone to estradiol is often maintained, but due to a variety of
factors, more testosterone is aromatized in fatty tissues, causing a further imbalance of the ratio of testosterone
to estrogen, i.e. too much estradiol and not enough testosterone. The result is a deficiency of beneficial
testosterone and an excess amount of estradiol.34
As men age, the amount of testosterone produced in the testes diminishes greatly. Yet estradiol levels remain
persistently high. The reason for this is increasing aromatase activity along with age-associated fat mass,
especially in the belly.5 Estradiol levels correlate significantly to body fat mass and more specifically to
subcutaneous abdominal fat. The epidemic of abdominal obesity observed in aging men is associated
with a constellation of degenerative disorders, including heart disease, diabetes, and cancer.9,35-38
Subcutaneous abdominal fat acts as a secretory gland, often producing and emitting excessive levels of estradiol
into an aging man’s blood.39 One’s waist circumference is a highly accurate prognostic measurement of future
disease risk, with excess estradiol secretion being at least one of the deadly mechanisms associated with the
difficult-to-resolve problem of having too much abdominal fat.5,40
Symptoms of excess estrogen in aging men include the development of breasts, having too much abdominal
weight, feeling tired, suffering loss of muscle mass, and having emotional disturbances. Many of these
symptoms correspond to testosterone deficiency as well.41
Protecting
Against
Double
the Stroke
Risk Toxic Estrogen Metabolites
Stroke is the third leading cause of death and the leading cause of age-related disability. Abnormal blood clotting
It is not just excess estradiol that poses health risks. Specific estrogen metabolites may also initiate
in the cerebral blood vessels is the most common cause of stroke. Excess estrogen promotes abnormal blood
and promote hormone-related cancers. Daily consumption of cruciferous vegetables (broccoli,
clots.1
cabbage,
withestrogen)
isoflavone-rich
soy foods60-64
In acauliflower,
study published
just last Brussels
year, bloodsprouts),54-59
levels of estradiolalong
(a potent
were measured
in a group ofconverts
2,197
mendangerous
aged 71 to 93
years of age.
Adjustment
for age,
diabetes, adiposity,
cholesterol,
atrial
these
estrogen
metabolites
(such
as hypertension,
16-alpha-hydroxyestrone)
to safe
ones (2fibrillation,
and
other
characteristics
were
made.
During
the
course
of
follow-up,
men
with
the
highest
blood
hydroxyestrone) that may protect against prostate cancer.
levels of estradiol had a 2.2-fold greater risk of stroke compared with those whose estradiol levels were lower
is associated with a constellation of degenerative disorders,
including heart disease, diabetes, and cancer.
One’s waist circumference is a highly accurate prognostic
measurement of future disease risk, with excess estradiol secretion
being at least one of the deadly mechanisms associated with the
difficult-to-resolve problem of having too much abdominal fat
For those who don’t eat these cancer-protective foods on a daily basis, low-cost supplements can
supply the most active constituents of cruciferous vegetables (such as indole-3-carbinol and
sulphoraphane)65-70 and soy (genistein and daidzein).
A normal body mass index(BMI) does not necessarily mean the
absence of Metabolic Syndrome. A person of normal weight can still
suffer from the effects of Metabolic Syndrome.
11.1 percent to 21.3 percent of individuals with a BMI 23.0 to 26.9
have metabolic syndrome.
Pro-inflammatory
High Omega 6:3 Ratio
Anti-inflammatory
Balanced omega 6:3 ratio
Researchers followed 208 apparently healthy, non-obese subjects for four to 11
years after baseline measurements of insulin resistance. The purpose was to
correlate insulin resistance at baseline to the development of various clinical
events including hypertension, coronary heart disease, stroke, cancer and type 2
diabetes.7 TheNo
subjects
were divided
into tertilesin
(groups
diseases
developed
the divided by3) of insulin
resistance at baseline: the most insulin-resistant tertile, intermediate insulin
subjects
with normal
resistance, and
no insulin resistance.
Duringinsulin
the follow-up period, 40 clinical
events occurred
among 37 subjects,
12 hypertension,
sensitivity,
whichincluding
was (according
tothree
hypertension and
2 diabetes,
nine cancer,
seven
coronary heart disease,
thetype
authors)
“seems
to be
truly
four stroke, and two type 2 diabetes. Twenty-eight of the 40 diseases occurred in
25 individualsremarkable.”
who were part of the most insulin-resistant tertile.
Facchini FS, Hua N, Abbasi F, Reaven GM. Insulin resistance as a predictor of age-related
disease. J Clin Endocrinol Metab 2001;86:3574-8.
“Grains
and bread contain
excessive amounts of proinflammatory omega-6 fatty
acids, gluten (to which many are sensitive)
and lectins that inflame the gut and
promote systemic disease. They are
deficient in such key nutrients as vitamins C,
A, B12 and beta-carotene.1 The pH of grains is
acidic. Lowering body pH can promote
inflammation, pain and osteoporosis.”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
“We are genetically accustomed to a 1:1 ratio of omega-6 (n6)
to omega-3 (n3) fatty acids. Under 4:1 is an acceptable ratio,
however, as the ratio increases, so does inflammation. The
average American's ratio range is from 10:1 to 30:1, reflecting
an extreme aberration that creates a pro-inflammatory state,
which is thought to promote pain; inflammation; cancer; heart
disease; Alzheimer's disease; inflammatory gut disease;
depression; osteoporosis; and most of the other chronic
diseases from which we suffer”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
“Consider oatmeal, a very common breakfast food, for
example. In one quarter of a cup of rolled oats, we are treated
to .44 mg of linoleic acid (n6) and .02 mg of linolenic acid
(n3), which reflects a 21:1 ratio of n6 to n3.3 White bread
provides a 21:1 ratio, while whole wheat contains a 27:1
ratio.3 Potato chips boast a 60:1 ratio, and corn chips provide
a 12:1 ratio”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
“Vegetables such as kale; broccoli; cauliflower; spinach;
collard and mustard greens; arugala; Swiss chard; and chicory
are excellent sources. The spring green mix, also called field
greens, California greens or Mesclun greens, is a great source.
These make an excellent salad and should replace iceberg
lettuce. Most fresh fish is rich in n-3s, as is wild game. Today,
people can even buy n-3-rich eggs, such as Eggland's Best,
found in most supermarkets. Health food stores typically
carry the Country Hen or Gold Circle Farms brands. Flaxseed
can be sprinkled on salads and fruits, and flaxseed oil can be
used in salad dressings.”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
“Broccoli Provides an Impressive 1:3
Ratio of N6 to N3, and Kale Offers a
1:1.3 Ratio, While Most Lettuces Give a
1:2 Ratio.3 Fish Ranges From 1:1 to 1:7
The ratio of n6 to n3 in fruits generally ranges from 2:1 to
1:1. For example, blueberries are noted for their heavy
concentration of bioflavonoids; they produce a 4:3 ratio of
n6:n3. Cherries are also rich in flavonoids and provide a
1:1 ratio. The banana, one of the more commonly eaten
fruits, possesses a 2:1 ratio”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
Most degenerative diseases
are caused by chronic
inflammation, so our
supplemental approach
should be supportive of
reducing inflammation.
Nicklas BJ, You T, Pahor M. Behavioral treatments for chronic systemic inflammation: effects of
dietary weight loss and exercise training. Can Med Assoc J 2005;172:1199-1209.
Omega-3 Supplements
“At This Point, It Should Be Clear That We Gorge Ourselves
With N6 Fatty Acids and Create a Pro-inflammatory State
That Drives Inflammation, Pain and Chronic Disease.
Regretfully, It Is Nearly Impossible to Ensure a Proper Ratio
of N6:n3 If You Plan to Do Anything but Shop and Prepare
Meals. I Strongly Suggest That You Immediately Begin a
Lifelong Supplementation Program Involving N3 Fatty Acids,
Particularly eicosapentaenoic Acid (EPA) and
docosahexanoic Acid (DHA). We Find These in Fresh Fish
and Wild Game to Varying Degrees. However, They Are Most
Commonly Associated With Fish, So EPA and DHA
Supplements Are Typically Referred to As Fish Oil.”
David Seaman, author of Clinical Nutrition for Pain, Inflammation, and Tissue Healing.
•EPA-DHA 720 provides 720 mg of omega-3 essential fatty
acids from cold water fish per softgel—eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA)—to help deliver
greater support in fewer softgels.
Supplies high levels of EPA and DHA, which have been
shown to support healthy function in body systems including
cardiovascular, immune, gastrointestinal, and
musculoskeletal. Omega-3 fatty acids such as EPA and DHA
are vital for healthy nervous system function.
Features a unique antioxidant blend of vitamin E, ascorbyl
palmitate, and rosemary to stabilize the oil for maximum
freshness.
Kaprex provides a safer option for effective joint relief. This proprietary
combination of selected plant components influences kinase signaling and
the formation of certain substances that are associated with minor pain.
Clinical testing suggests that Kaprex may offer a high degree of predicted
cardiovascular, gastric, renal, and liver safety.
Provides effective joint relief that is worry-free.
Modulates prostaglandin E2 (PGE2) production at specific target cells.
Features SKRMs in the form of THIAA to modulate kinase activity in
favor of good health.
The ingredient synergy of Tetrase™, oleanolic acid, and rosemary provide
efficacy at a low dose for a maximum cost-effectiveness.
Developed through the ExpresSyn™ Process, which combines cell
proteomic research, safety evaluations, human ex vivo research, and
clinical testing for maximum safety and effectiveness.
EACH SOFTGEL SUPPLIES:A proprietary blend of: 350 mg
Tetrase™, (Tetrahydro-iso-alpha acids complex†, from hops) (Humulus lupulus L.),
Oleanolic Acid (from olive leaf extract, Olea europaea), Rosemary Leaf Extract
(Rosmarinus officinalis)
Inflavonoid is expertly formulated to provide relief from
minor pain and support healthy muscle tissue. It is the perfect
choice for patients whose muscles are impacted by physical
stressors, poor posture, and even inactivity.
Supports healthy eicosanoid synthesis such as prostaglandins,
thromboxanes, and leukotrienes that can affect muscle and
connective tissue.
Provides Ayurvedic herbs traditionally used to support
healthy muscle tissue.
Provides lemon bioflavonoids and vitamin C, which help to
protect connective tissues from damaging free radicals.
UltraInflamX® Plus 360° is a medical food formulated to provide specialized
nutritional support—including reduced iso-alpha acids (RIAA, from hops), Lglutamine, and easily digestible rice protein—for patients experiencing inflammation
and pain associated with inflammatory bowel disease (IBD), such as Crohn's
disease and ulcerative colitis.

Features selective kinase response modulators (SKRMs) in the form of
RIAA, which has been shown to beneficially influence the function of enzymes
involved in inflammatory processes.

RIAA has demonstrated potent antioxidant activity and research
suggests that it may help improve overall redox status through influencing
inflammation signaling molecules such as NF-κB, COX-2, and PGE2

Includes ginger and rosemary, which may help support healthy
eicosanoid and cytokine metabolism

Provides turmeric extract, which has been shown in research to inhibit
the activities of a wide variety of enzymes, cytokines, eicosanoids, and reactive
species implicated in pain and inflammation

Supplies a low-allergenic potential protein base in the form of rice
protein concentrate
HOW TO AGE RAPIDLY OR NOT!
by Pauline N. Harding, MD, who is residency trained in Internal Medicine, Board
Certified in Family Practice, and licensed as a Nutrition
Counselor. She is an instructor in the Department of Family
Practice at the University of Illinois College of Medicine in
Chicago. She has been on the speakers' forum for the Rush
.Presbyterian
. . the "chin
forward"
posture
also invites
rapid
St. Luke's
Medical
Center Conference
for BodyMind Healing and the Wilson
Foundation Conference on
aging,
Ethics forespecially
High School of
Science
Teachers,
and she has acted
cognitive
functions.
as panel discussant for the American Psychological
Association. Dr. Harding is Medical Director at Prairie Trail
Family Medicine in Winfield, Illinois. Her medical practice
embraces a potpourri of natural healing techniques,
especially as they apply to problems associated with
environmental sensitivity and other allergies, fibromyalgia,
chronic fatigue, colitis, sleep disturbances, and menopause.
The inflammatory propensity survey
Please check any of the boxes that may apply to you.
 I have or had been diagnosed with any of the following: arthritis, fibromyalgia, chronic fatigue syndrome, sinusitis,
allergies, acne, asthma, digestive conditions, flu symptoms, dysmenorrhea, endometriosis, Alzheimer’s disease, Parkinson’s
disease, multiple sclerosis, cancer, heart disease, osteoporosis, hypertension, depression, the insulin resistance syndrome
(pre-diabetes), or diabetes.
 I seem to wake up with lots of joint stiffness.
 I take anti-inflammatory meds at least once per week.
 I regularly eat cheese in more than condiment size portions.
 I have an unhealthy BMI or I need to lose weight
 I have a waiste to hip ratio of greater 1:1
 I have neck or back pain and or stiffness
 I feel mentally drained most days of the week and have feelings of depression.
 I feel older that what I should for my age.
 I am chronically tired.
 I consume breads and cereals daily
 I consume refined sugar and or baked goods several times per week
 I consume fried foods and other foods that may have trans fats
 I consume commercially salad dressings and or mayonnaise as well as foods cooked with vegetable oils like corn and
safflower
 I consume processed daily products.
 I consume meats and other animal products that are grain fed.
 I find it hard to exercise regularly.
 My skin seems to be dry and lacks resiliency
 I have allergy symptoms and seem to be prone to seasonal changes
 I am a smoker.
If you have checked any of the boxes above, there is a strong likelihood that you
have at lease a mild if not a significant inflammatory condition.
•Inflammation, Heart Disease and Stroke: The Role of C-Reactive Protein
How does inflammation relate to heart disease and stroke risk?
“Inflammation” is the process by which the body responds to injury or an infection. Laboratory evidence and findings from clinical and population studies suggest that
inflammation is important in atherosclerosis (ath”er-o-skleh-RO’sis). This is the process in which fatty deposits build up in the inner lining of arteries.
C-reactive protein (CRP) is one of the acute phase proteins that increase during systemic inflammation. It’s been suggested that testing CRP levels in the blood may be
an additional way to assess cardiovascular disease risk. A more sensitive CRP test, called a highly sensitive C-reactive protein (hs-CRP) assay, is available to
determine heart disease risk.
The American Heart Association and the Centers for Disease Control and Prevention published a joint scientific statement in 2003 on the use of inflammatory markers
in clinical and public health practice. This statement was developed after systematically reviewing the evidence of association between inflammatory markers (mainly
CRP) and coronary heart disease and stroke.
What’s the role of CRP in predicting recurrent cardiovascular and stroke events?
A growing number of studies have examined whether hs-CRP can predict recurrent cardiovascular disease, stroke and death in different settings. High levels of hs-CRP
consistently predict recurrent coronary events in patients with unstable angina and acute myocardial infarction (heart attack). Higher hs-CRP levels also are associated
with lower survival rates in these patients. Many studies have suggested that after adjusting for other prognostic factors, hs-CRP is useful as a risk predictor.
Studies also suggest that higher levels of hs-CRP may increase the risk that an artery will reclose after it’s been opened by balloon angioplasty. High levels of hs-CRP
in the blood also seem to predict prognosis and recurrent events in patients with stroke or peripheral arterial disease.
What’s the role of hs-CRP in predicting new cardiovascular events?
Scientific studies have found that the higher the hs-CRP levels, the higher the risk of having a heart attack. In fact, the risk for heart attack in people in the upper third of
hs-CRP levels has been determined to be twice that of those whose hs-CRP level is in the lower third. These prospective studies include men, women and the elderly.
Studies have also found an association between sudden cardiac death, peripheral arterial disease and hs-CRP. However not all of the established cardiovascular risk
factors were controlled for when the association was examined. The true independent association between hs-CRP and new cardiovascular events hasn’t yet been
established.
What causes low-grade inflammation?
The major injurious factors that promote atherogenesis — cigarette smoking, hypertension, atherogenic lipoproteins, and hyperglycemia — are well established. These
risk factors give rise to a variety of noxious stimuli that cause the release of chemicals and the activation of cells involved in the inflammatory process. These events are
thought to contribute not only to the formation of plaque but may also contribute to its disruption resulting in the formation of a blood clot. Thus, virtually every step in
atherogenesis is believed to involve substances involved in the inflammatory response and cells that are characteristic of inflammation.
In addition, there is also research that indicates an infection — possibly one caused by a bacteria or a virus — might contribute to or even cause atherosclerosis. The
infectious bacteria, Chlamydia pneumoniae (klah-MID'e-ah nu-MO'ne-i), has been shown to have a significant association to atherosclerotic plaque. The herpes
simplex virus has also been proposed as an initial inflammatory infectious agent in atherosclerosis.
The notion that chronic infection can lead to unsuspected disease isn't foreign to most doctors. For example, bacterial infection with Helicobacter pylori is now known to
be the major cause of stomach ulcers. The treatment for this condition now routinely includes antibiotic therapy.
Should I have my CRP level measured?
If a person’s cardiovascular risk score — judged by global risk assessment — is low (the possibility of developing cardiovascular disease is less than 10 percent in 10
years), no test is immediately warranted. If the risk score is in the intermediate range (10–20 percent in 10 years), such a test can help predict a cardiovascular or
stroke event and help direct further evaluation and therapy. However, the benefits of such therapy based on this strategy remain uncertain. A person with a high risk
score (greater than 20 percent in 10 years) or established heart disease or stroke should be treated intensively regardless of hs-CRP levels.
What is the normal range of hs-CRP level?
If hs-CRP level is lower than 1.0 mg/L, a person has a low risk of developing cardiovascular disease.
If hs-CRP is between 1.0 and 3.0 mg/L, a person has an average risk.
If hs-CRP is higher than 3.0 mg/L, a person is at high risk.
If, after repeated testing, patients have persistently unexplained, markedly elevated hs-CRP (greater than 10.0 mg/L), they should be evaluated to exclude
noncardiovascular causes. Patients with autoimmune diseases or cancer, as well as other infectious diseases, may also have elevated CRP levels.
The American Heart Association and the Centers for
Disease Control and Prevention published a joint scientific
statement in 2003 on the use of inflammatory markers in
clinical and public health practice.
r
“… esearchers found that vitamin D
deficiency is associated with
increased inflammation in
otherwise healthy people. Increased
inflammation in
the body can increase the risk of chronic
inflammatory conditions, including
coronary heart disease (CHD) and
diabetes. Further, the researchers found
that
inflammation was lowered by simple
vitamin D” (supplementation)
Vitamin D Lowers Inflammation
Contributed by John Jacob Cannell, MD, executive director of The
Vitamin D Council
Recommended Inflammatory Markers
Indicating the Relative Risk of Chronic
Degenerative diseases:
• hs CRP
• Vitamin D3 levels
• Insulin Resistance (2 hr)
• Sed rate