Transcript 投影片 1
The presentation is about to begin……. Nitric Oxide & Health The Wonderwork of Nitric Oxide Presented by Healthway C.T.M.L., Inc. Nitric Oxide 1998 Nobel Prize in Physiology/Medicine The 1998 Nobel Prize for Physiology or Medicine was awarded to 3 American scientists for their research on NO (Nitric Oxide). They discovered that NO, a gas, is responsible for transmitting important signals and regulating cellular functions in the human body. Robert F. Furchgott Dept. of Pharmacology, SUNY Health Science Center Louis J. Ignarro Dept. of Molecular And medical Pharmacology UCLA School of Medicine Los Angeles Ferid Murad Dept. of Integrative Biology Pharmacology and Physiology University of Texas Medical School Houston The Winners of 1998 Nobel Prize 3 Nobel Prize Winners receiving their awards from the hands of His Majesty the King of Sweden. World Famous Scientist: Alfred Nobel & Nitroglycerine Alfred Nobel is the founder of Nobel Prize. He starts his experiments with nitroglycerine in 1860. He also invented dynamite in 1866 and later built up companies and laboratories in more than 20 countries all over the world. Ironically, when Nobel was taken ill with heart disease, his doctor prescribed nitroglycerin, but he refused to take it. It has been known since last century that the explosive, nitroglycerin, has beneficial effects against chest pain. However, it would take 100 years until it was clarified that nitroglycerin acts by releasing NO gas. Cardiovascular Disease & Hardening of the Arteries The President of the American Heart Association, Dr. Valentin Fuster said, “The discovery of Nitric Oxide and its function is one of the most important in the history of cardiovascular medicine.” Nitric oxide Dr. John P. Cooke, Director of Vascular Medicine at Stanford University Medical School, states that- Even when blood cholesterol is high, if sufficient nitric oxide from arginine, is being produced, the vessels will be protected from the development of plaque, affording protection from atherosclerosis. Dilated Artery Cardiovascular Disease There is a high incidence of cardiovascular disease among the old. The incidence is 15% for the people over age 40, and men have a high risk factor than women. The death rate for heart disease and stroke is around 49%. Cardiovascular disease ranks as world’s No.1 killer, claiming the lives of 15 million people. According to statistics, stroke deaths occur more often during periods between 2:00 a.m.- 6:00 a.m. This may due to NO level is low at nights. Also, heart disease patients produce less nitric oxide than normal persons. NO Production in Human Body Healthy People Unhealthy People Cardiovascular disease patient NO & Blood Vessels From 70’s, Dr. Ferid Murad started experiments with Nitroglycerin. Until 1997, he found out that nitroglycerin works by releasing nitric oxide. NO molecules from the endothelium travel into smooth muscle cells, set off a cascade of cellular reactions that cause the cell’s contractile filaments to slide. As a result, smooth muscle cells relax and blood vessel dilates. Healthy people– Healthy immune system Unhealthy people– Weak immune system According to the research, the cells of your body decline 2% per year in effectiveness starting at age 21! Therefore, you need to deposit an equal amount in your nutritional bank account to maintain your health. Dr. Cooke said, “endothelium-made nitric oxide is your body’s strongest self defense against heart attacks and stroke…preventing and reversing hardening of the arteries.” 擁A healthy endothelium is the cardiovascular cure Dr. Cooke points out, the person with healthy blood vessels, by eating an arginine rich diet, manufactures sufficient nitric oxide but- most of us have unhealthy blood vessels and unhealthy diets! Furthermore, he states that high cholesterol, even in healthy young people, and diseased coronary arteries interferes with the production of nitric oxide by the body. 一Ample Nitric Oxide production dissolves plaque Nitric oxide, endogenously produced gas that acts as a signaling molecule in the body. Signal transmission by gas, produced by one cell, which penetrates membranes and regulates the function of other cells is a revolutionary breakthrough in the human organism. Scientists believe that insufficient nitric oxide production in human body leads to a variety of diseases. NO Performance Function in Cardiovascular System Function in Nerve Transmission Function in Immune System Function in Respiratory & Endocrine System NO Function in Cardiovascular: Relaxes blood vessels keeping them open, pliable, and elastic Preventing platelets and white blood cells from sticking to the vessel wall Preventing arterial spasms Atherosclerosis Atherosclerosis is the buildup of deposits of fatty substances on the insides of the artery walls. This causes thickening and hardening of the arteries, high blood pressure chest pain, heart attack, stroke, and sudden cardiac death. According to recent research, the average persons’ cholesterol level is raised up to 20%; and around 10% of children triglyceride level is higher than normal. Scientist evidence shows by lowering 1% of cholesterol reduces 2% of incidence in Myocardial Infraction. Cholesterollowering also reduces the hardening of the arteries. Hypertension High blood pressure is the most important risk factor for cardiovascular disease. Many people believe the effective treatment of hypertension is a key reason for the accelerated decline in the death rates for heart attack, heart disease, and stroke. Double NO in blood vessels,pliable blood vessels Normal Hypertension Coronary Artery Disease Cerebral Embolism 血液平衡疗法对原发性高血压，冠状动脉硬化性心脏病，动脉硬化脑梗塞，病人血浆一氧化氮的影响， 健康对照组， 血液平衡前对照， 一次血液平衡后， 三次血液平衡后。 n=56,x±s**p<0.01与对照组比较；++p<0.01与血液平衡前比较。 二次血液平衡后， Cardiovascular System Blood vessels bring oxygen and nutrients to the heart, brain, and various human body. Especially, heart and brain consume most of oxygen that body produced, around 60%. When the body is under heavy physiological stress or trauma, it requires more nitric oxide; otherwise may damage blood vessels and cause cardiovascular disease such as heart disease, stroke….. Coronary Artery Disease Coronary artery disease generally refers to the buildup of cholesterol in the inside layers of the arteries. This will slowly narrow the flow of blood through the vessels, and the muscle it supplies will not get enough blood. The plaque weakens the wall. A crack may develop in the plaque and a blood clot may form~ this is the mechanism of most heart attacks. Hardening of Arteries Hardening of arteries is a common disorder of the arteries. It often shows no symptoms until flow within a blood vessel has become seriously compromised. Typical symptoms include chest pain when a coronary artery is involved, or leg pain when a leg artery is involved. Fat, cholesterol and other substances accumulate in the walls of arteries and form atheromas or plaques. Blood Vessel Disease Risk as: 1. contracted artery, increase blood pressure; 2. increase stickiness of platelets,damage endothelium; 3. the hardening of arteries, blockage in coronary artery; Nitric Oxide in Nerve System: Nitric Oxide Nourishes Brian Cells. Nitric Oxide enhanced nerve cells communication and longterm memory storage. NO and Brain Brain researchers have begun to examine the role of NO in diseases such as Alzheimer’s and Parkinson’s. In patients suffering either of these disorders, there is frequently a significant reduction in the nitric oxide being produced in their brain. Cerebri anterior Cerebri Media Cerebri posterior Inhibiting the enzyme used to make NO caused constriction of the arteries supplying the brain. A stroke occurs when a blood vessel bring oxygen and nutrients to the brain bursts or is clogged by a blood clot or some other particle. Cerebral hemorrhages Cerebral embolism NO Function in Immune System: Strengthen the body’s defense against infection Retards tumor growth by enhancing immune function Ample production of Nitric oxide in white blood cells to kill invading bacteria and parasites NO reduces lung disorders & help HGH release Dr. Jonathan S. Stamler, professor of Medicine at Duke University Medical Center, once said, “NO does everything, everywhere.” NO involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how digits and arms move. NO & Body Function Individuals without sufficient nitric oxide production are likely to develop heart or blood vessel disease. Scientists believe一The decrease of nitric oxide production in human body decreases the function and health of normal cells. Therefore, disease may follow….. For example: 1. Hypertension (high blood pressure) 2. Stroke 3. Coronary artery disease 4. Heart failure 5. Diabetes Mellitus 6. Other diseases Unhealthy Healthy Health Seminar Please call: Healthway C.T.M.L. 1-888-879-8688