Transcript Lecture 2

Lecture 2
Neurons, Muscles and Motor
Units
Voluntary movement begins....
Brain
Spinal cord
Motor nerves
Muscles
Movement
Motor system
Musculoskeletal Sensory system
System
The Nervous System
Central nervous
System (CNS).
 Brain
 Spinal cord
Peripheral Nervous
System (PNS).
 Everything else
Somatic
Autonomic
Nervous system cells
Neuron
Basic unit of the NS

Glial
Support, myelin,
scavengers.

The neuron:
Consists of three major parts:
 Soma or cell body (nucleus).
 Axon (carries the output signals
generated by the cell).
 Dendrites (inputs into the cells).
How is the info. being
transferred from cell to
cell?
Synapses....
Connections to other cells, consist of
three main components:
 Presynaptic membrane
 Postsynaptic membrane
 Synaptic cleft
Presynaptic
membrane
Synaptic
vesicles
Neurotransmitter
Synaptic cleft
Postsynaptic
membrane
Neuron to neuron synaptic
transmission uses chemical
substances called
neurotransmitters.
Signal transportation...
Action potential
Transmission of information
through the NS in the form of
electrical impulse.
Depolarization
Resting
Potential
Stimulus
Hyperpolarization
Speed of conduction with regard
to the neural signal
 Higher
speed along thick neural
fibers.
 Higher speed in myelin covered
fibers.
Primary Afferent / Sensory Axons
One Presynaptic action
potential is usually unable to
force the membrane of the
postsynaptic neuron to
generate an action potential subthreshold.
(Muscle-exception, will always
stimulate the muscles due to the
high voltage).
How do we get an action potential?
In order to generate an action
potential, the Postsynaptic
membrane requires to sum up the
effects of a number of signals.
This is what we call summation.
There are two types of summation:
 Temporal summation
 Spatial summation
Temporal summation

An accumulative effect on the
membrane potential of a postsynaptic
cell; caused by chemical transmissions
from one or more synaptic terminals
occuring so close together in time that
each postsynaptic potential affects the
membrane before the voltage has
returned to the resting potential after the
previous stimulation.
Spatial summation
 An
accumulative effect on the
membrane potential of a
postsynaptic cell, caused by
several different synaptic terminals
stimulating a postsynaptic cell
membrane.
Muscles...
Muscles....
 Contractile
components:
Myofibril
Muscle fiber
Muscle fascicles
 Elastic components:
Tendon
Neuromuscular synapse/junction

A region of contact between a single
Presynaptic fiber and a muscle fiber.

The two fibers are very close to each
other but no direct contact.
Motor Unit
The smallest functional unit of the
neuromotor system.
 Typically, each muscle fiber is
innervated by only one axon branch.
 The motorneuron and the muscle fibers
it innervates are called a motor unit.

Types of contraction
 A single
action potential to a
muscle that responds with one
contraction is a TWITCH.
 Many action potentials happen at
the same time, contraction is
sustained, a TETANUS is
observed.
Muscle contraction
Decision by the CNS for muscle
contraction
 Signal is sent to neurons in the spinal
cord
 Signal is propagated through the axons
to appropriate muscles
 Muscles are activated

Muscle contraction
CNS command to contract
Signal is sent to the spinal cord
Signal propagated to muscles via axons
Muscles are activated