Transcript Factor VIII Inhibitor

Rheumatology Review
How to Approach Arthritis
DURATION
ACUTE
CHRONIC
• Crystal Deposition
• Infection
• Early Chronic
• Trauma
• Hemarthrosis
INFLAMMATION?
YES
NO
• OA
JOINT INVOLVEMENT
MONO
OLIGO
POLY (symmetry)
• Early Oligo/Poly
• Chronic/Indolent
Infection
• Seronegative
disease
• Sjögren’s
• RA
• SLE
• Seronegative
• Chronic
Tophaceous Gout
Diagnostic Criteria for SLE

Any 4 of the following 11 criteria (simultaneously or
sequential) needed to help diagnose SLE
 Serositis (pleuritis, pericarditis)
 Oral Ulcers
 Non-deforming Arthritis
 Photosensitivity
 Blood disorders (such as hemolytic anemia or
pancytopenia in absence of offending drug/agent)
 ANA positive
 Renal Disease
 Malar Rash (distinct from photosensitivity)
 Discoid Rash
 Neurologic Disorders (seizures, psychosis, etc)
 Presence of Anti-Smith, anti-phospholipids, antidsdna, false positive syphilis test
Diagnostic Criteria for RA

Any 4 of the following 7 criteria. Primarily used for
research purposes, made prior to discovery of
anti-ccp
 Morning stiffness > 1hour for at least 6 weeks
 Arthritis and soft tissue swelling of at least 3
joints for > 6 weeks
 Arthritis of hand joints > 6 weeks
 Symmetric arthritis for > 6 weeks
th percentile
 Rheumatoid factor above the 95
 Erosive arthropathy on films
 Subcutaneous nodules
Name That Antibody
Sjögren’s, Lupus,
neonatal heart
block
Anti-Ro (SS-A), Anti-La (SS-B)
Lupus
Anti-Smith, Anti-Double Stranded
CREST
Anti-Centromere
Scleroderma
RA
Antiphospholipid
Syndrome
Anti-Scl70 (anti-topoisomerase)
Anti-CCP, RF
Lupus Anticoagulant
Name That Antibody
Mixed Connective
Tissue Disease
Anti-RNP
Stiff Man Syndrome
Anti-GAD
CREST
Anti-Centromere
Scleroderma
Anti-Scl70 (antitopoisomerase)
Dermato/Polymyositis
Celiac Disease
Anti-Mi-2, Anti-Jo1
Anti-Transglutaminase
Name That Antibody
Autoimmune Hepatitis
Anti-Smooth Muscle
Primary Biliary
Cirrhosis
Anti-Mitochondrial Antibody
Churg-Strauss,
Microscopic
Polyangitis
p-ANCA
Wegener’s
c-ANCA
Drug Induced Lupus
Anti-Histone Abs
Seronegative Arthritis
HLA-B27
Gratuitous photos
Name That Antibody
Sjögren’s, Lupus,
neonatal heart
block
Lupus
CREST
Scleroderma
RA
Antiphospholipid
Syndrome
Anti-Ro (SS-A), AntiLa (SS-B)
Anti-Smith, AntiDouble Stranded Abs
Anti-Centromere
Anti-Scl70 (antitopoisomerase)
Anti-CCP, RF
Lupus Anticoagulant
Name That Antibody
Mixed Connective
Tissue Disease
Anti-RNP
Stiff Man Syndrome
Anti-GAD
CREST
Anti-Centromere
Scleroderma
Anti-Scl70 (antitopoisomerase)
Anti-Mi-2, Anti-Jo1
Dermato/Polymyositis
Celiac Disease
AntiTransglutaminase
Name That Antibody
Autoimmune Hepatitis Anti-Smooth Muscle
Ab
Primary Biliary
Cirrhosis
Churg-Strauss,
Microscopic
Polyangitis
Wegener’s
Anti-Mitochondrial
Antibody
p-ANCA
Drug Induced Lupus
Anti-Histone Abs
Seronegative Arthritis
No Ab. HLA-B27
c-ANCA