Transcript ETP Global Animal Health Danish Proposals and the

European Technology Platform for
Global Animal Health (ETPGAH)
Danish Mirror Group
Ideas to be transformed into research
projects
Copenhagen
8 September 2009
Jim Scudamore
1
Ideas to be transformed into
research projects
1.
2.
3.
4.
5.
Outline of the Presentation.
Introduction
The Action Plan
Danish Proposals
Funding of Proposals
Conclusions
2
ETP Global Animal Health
The Vision
To facilitate and accelerate the
development and distribution of
the most effective tools for
controlling animal diseases of
major importance to Europe and
the rest of the world, thereby
improving human and animal health,
food safety and quality, animal
welfare, and market access,
contributing to achieving the
Millennium Development Goals.”
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Published August 2005
ETP Global Animal Health
The Strategic Research Agenda
The SRA is the mechanism to deliver
the vision.
SRA has 2 overarching objectives:• to deliver new and improved
tools for the control of major
diseases and
• to deliver the 61
recommendations within the 6
themes of the SRA which in turn
will facilitate the development and
delivery of new tools
Published May 2006
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ETP Global Animal Health
Action plan
• 61 Recommendations
• Proposals concerning
what needs to be done
• Action Plan is much more
specific
• Designed to be converted
into research or
information gathering
initiatives
Published July 2007
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ETP Global Animal Health
Action plan
The Action Plan is
intended to be a
flexible working
document, subject to
regular review and up
dating by the ETPGAH
to ensure that the
SRA is on target and
that the
recommendations are
being delivered.
Published July 2007
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ETP Global Animal Health
The Process
DISCONTOOL
2008
Stakeholders,
led by industry,
come together
to agree on
a common
vision for the
technology
Vision paper:
“EU TP Global
Animal Health”
Launch Dec 2004
Final version
August 2005
Stakeholders,
define a
Strategic Research
Agenda setting
the necessary
mid- to longterm
objectives
Strategic
Research
Agenda:
Published May
2006
Stakeholders,
implement the
Strategic Research
Agenda with the
mobilisation of
significant human
and financial
resources
EMIDA
2008
ICONZ
2009
Action Plan:
Published July
2007
Examples from
FP7
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Ideas to be transformed into
research projects
1.
2.
3.
4.
5.
Outline of the Presentation.
Introduction
The ETPGAH Action Plan
Danish Proposals
Funding of Proposals
Conclusions
8
ETP Global Animal Health
Action plan
•
Chapter 2 details
the actions to
implement the 61
recommendations
of the SRA using a
standard format
for consistency
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ETP Global Animal Health
Action plan
Contents of the plan
Chapter 2
Themes & Recommendations within
themes
Detailed Proposals
1 Prioritise
animal
diseases
and
infections
2
Gap
Analysis
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8
Action plan
3
Fundamental
Science
5
4
Enabling
factors
17
5
Regulatory
& Societal
Issues
6
Global
Perspective
5
8
Finalised and submitted to the EU
Commission in July 2007
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ETP Global Animal Health
Action plan
•
Chapter 3 Deals
with the research
requirements for
the priority
diseases
specifically dealing
with prioritisation
and gap analysis
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ETP Global Animal Health
Action plan
–
–
–
–
–
Annex 1 Tasks for the
European Centre for
Epidemiology and
Infectious animal
disease
Annex 2 – Categories
of Disease
Annex 3 – Prioritisation
Model
Annex 4 – Bluetongue
Disease Information
Annex 5 – Bluetongue
Gap Analysis
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ETP Global Animal Health
Action Plan
How will the action plan be used.
Template
Guidance
Liaison
Lobbying
Funding
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ETP Global Animal Health
Action Plan
The Action plan serves to provide an input for:1.
2.
3.
4.
Future EC Framework Programmes which will
involve close cooperation with EC, Member States
and European Parliament representatives.
Future national research programmes where it will
provide better opportunities to align and coordinate
national programmes
Public/private research partnerships exploring ways
to develop an integrated approach to developing
new tools to control animal diseases.
Industry which has an important role working in
partnership to develop new products, which can be
delivered in the field.
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Ideas to be transformed into
research projects
1.
2.
3.
4.
5.
Outline of the Presentation.
Introduction
The Action Plan
Danish Proposals
Funding of Proposals
Conclusions
15
ETP Global Animal Health
Danish Proposals and the Action Plan
Proposals
1. A European Academic
Network for Vaccine
Research
2. Coordination of
Veterinary
Epidemiological
Research on
Infectious Diseases in
Europe
3. Endemic diseases
1.
2.
3.
4.
5.
6.
Questions
What is new?
How do these
proposals fit into the
action plan?
What are the priority
diseases?
What is an endemic
disease?
What benefits would
they bring?
What is the best way
forward?
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A European Academic Network for
Vaccine Research.
Objectives:
•
To promote the development of vaccines for endemic diseases including
MUMS
Deliverables
•
•
•
•
•
•
•
To support all aspects of design, development and testing of vaccines
and strengthen collaboration (AP3.1)
To train young researchers. (AP 4.5)
To advise and propose strategies for future research of more generic
and fundamental nature in all aspects of vaccine development.(AP4.3)
To provide information, advice and decision support to European
authorities.
To identify the main problems related to vaccine research from the
perspective of all stakeholders
To identify global centres of excellence
To identify subjects and areas of importance in relation to innate
immunity, T-cell immunity, DNA vaccines, Bio-informatics, antigen
delivery systems.(AP3.3). Genomic and proteomic approach
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Coordination of Veterinary Epidemiological
Research on Infectious Diseases in Europe
(1)
Objectives:
•
To ensure the coordination of research and education activities in the area of
veterinary epidemiology of infectious diseases.
Deliverables
•
•
•
•
•
•
•
•
•
To create a cost effective body to coordinate animal health research at a European
level.
To act as a coordination body for epidemiology in the EU
To train young researchers. (AP 4.5)
To initiate timely projects related to veterinary epidemiological research into
infectious diseases.
To provide objective, transparent, and comparable information concerning the
occurrence, dissemination and control of animal diseases.
To provide easy access to new animal health research concerning risk based and
targeted surveillance
To develop risk based principles to optimise the use of resources
To contribute through horizon scanning to an updated picture of the threats as
regards animal diseases.
To contribute to the Community Animal Health plan
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Coordination of Veterinary Epidemiological
Research on Infectious Diseases in Europe
(2)
Deliverables
•
•
•
•
To initiate multinational harmonised data collection,
epidemiological studies and reporting of trans border
diseases outbreaks
To develop and use modelling for animal diseases and
surveillance to promote scenarios for the control including
cost benefit of potential control measures.
To initiate research in sampling and survey methodologies
including risk based principles in disease monitoring or
surveillance in order to secure a more focused use of
resources
To identify challenges including animal heath questions
related to climate change to ensure European preparedness.
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ETP Global Animal Health
Action Plan
3.2.
Establish a European Centre for Epidemiology and Infectious
Animal Diseases.
SRA Recommendations. 21
Objective: In Europe, epidemiological research is carried out in national
institutions and is mainly organised and funded by the EU Member States. A
central institution with coordinating responsibilities for fundamental and
applied research in the field of infectious diseases and epidemiology is
required. In view of the recent enlargement of the EU there is a requirement
for an efficient infrastructure or centralised institution for fundamental and
applied research into epidemiology and infectious diseases.
Deliverables:
• A scoping study of the options available for improving applied research into
epidemiology and infectious diseases and the development of an
appropriate infrastructure with responsibility for training epidemiologists to
create a critical mass for the future
• A report into the pros and cons of a virtual versus a physical centre
• The implementation of the most appropriate option either the establishment
of a specific or a virtual European Central Institution for Epidemiology and
Animal Infectious Diseases. Alternatively a fully funded community
reference laboratory could be established. The centre to act as a repository
for a range of databases on disease information.
• Availability of a budget for the centre whether virtual or physical
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ETP Global Animal Health
Action Plan
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•
•
•
•
•
•
Tasks for European Centre for Epidemiology and Infectious Animal
Disease
Development of knowledge along the entire animal health chain, e.g.:
- research in the area of interaction between epidemiology and
infection biology focussed
on the development of integrated control strategies;
- integration of innovation by research groups with development of
vaccines and
diagnostics by the pharmaceutical industry;
- policy support of governmental bodies in the fields of prevention and
control.
Development of risk assessment models
Data mining techniques to be developed and implemented
Reference Centre for education and training, particularly in the field of
epidemiology.
Integration of research with research centres for human infectious
diseases.
Management of a common European database for surveillance and
early warning.
Initiation of joint research programmes and exchange of expertise with
centres in developing countries, in particular the source countries for
(re)emerging infectious diseases (i.e. twinning)
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ETP Global Animal Health
Danish Proposals and the Action Plan
Endemic diseases.
Objective
•
To develop a broader scientific approach to welfare threatening
diseases
Deliverables
–
–
–
–
Multidisciplinary approach to causes and best intervention
strategies
Explore links between immunity development, pathogenesis
and epidemiology to areas such as business and animal
health economics, animal ethics and sociology
Explore from the welfare perspective as opposed to production
perspective
Define welfare spanning farmer and consumer
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ETP Global Animal Health
Danish Proposals and the Action Plan
Diseases in the Action plan.
In the Action plan the process was developed
further with the result that 47 priority diseases
in 3 groups were listed.
Group 1 Epizootic diseases and diseases for surveillance
Group 2 : Zoonoses and food-borne diseases
Group 3: Major food-producing animal disease complexes
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FP7 projects contributing to research
Group 1 Epizootic
diseases and diseases
for surveillance
Vaccine
Diagnostic
African Horse Sickness
FP7
African Swine Fever
Pharmac
eutical
Control
Strategy
Capacity
building
FP7
FP7
FP7
FP7
ASFRISK
ASFRISK
ASFRISK
ASFRISK
FP6
FP6
FP6
FP6
Avian Influenza
FP6
Bluetongue
FP6/7
FP6/7
Classical Swine Fever
CSFV
GoDIVA
CSFV GoDIVA
Foot & Mouth Disease
Discovac
Discovac
Discovac
ARBO
ZOONET
ARBO
ZOONET
ARBO
ZOONET
ARBO
ZOONET
ARBO
ZOONET
ARBO
ZOONET 24
FP6/7
FP6/7
CSFV
GoDIVA
CSFV
GoDIVA
FP6/7
Contagious Bovine
Pleuro Pneumonia
Discovac
CSFV GoDIVA
Discovac
Peste des Petits
Ruminants
Rift Valley Fever
Ruminant Pox Virus
infection
Swine Vesicular
Disease
West-Nile Virus
Group 2 : Zoonoses and food-borne
diseases
Vaccine
Diagnostic
Pharmaceutical
Control
Strategy
Capacity
building
ICONZ
TB_STEP
ICONZ
TB_STEP
ICONZ
TB_STEP
ICONZ
TB_STEP
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
FP7
FP7
FP7
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
ICONZ
Anthrax
Nipah virus infection
Bovine Tuberculosis
Brucellosis
Chlamydia
Cryptosporidium
Cysticercosis
Echinococcosis
Food-borne bacterial: Salmonella
E. Coli
Campylobacter
Food-borne viral (Hepatitis E Virus
Leishmaniasis
Leptospirosis
Q Fever
Rabies
Trypanosomiasis
Transmissible Spongiform
Encephalopathies
ICONZ
ICONZ
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FP6 and FP7 projects contributing to research
Group 3: Major foodproducing animal disease
complexes
Parasitic gastro-intestinal
diseases
Liver Fluke
Coccidiosis
Nematodes
Vaccine
Diagnostic
Pharmaceutical
Control
Strategy
Capacity
building
FP7/10
FP7/10
FP7/10
FP7/10
FP/10
FP7/10
FP7/09
FP7/09
FP7 2009
FP7/09
FP7/09
FP7/09
Paratuberculosis (Johne’s)
Mastitis :
Staph.aureus mastitis
Environmental/Streptococcal
mastitis
Small ruminant mastitis
Respiratory – Swine
PRRS – CG3 + HN
PCV II
SIV
A. pleuropneumonia
Mycoplasma
Respiratory – Bovine
BVDV
BRSV
BHV-I (IBR)
Mycoplasma
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ETP Global Animal Health
Action Plan
Theme 3 Fundamental Science
No
Item
Status
Project title
Comment
3.1
Support and Strengthen
Fundamental Sciences in
the EU
Partial
ongoing
various
A number of FP7 projects target
research to areas of fundamental
science
A European Academic Network
for Vaccine Research
3.2
Establish a European Centre for
Epidemiology and Infectious
Animal Diseases.
To
commence
3.3
Specific Requirements for
Fundamental Research
Host pathogen interaction
Fundamental immunology
Epidemiology
Genomics
Bio-informatics.
(i) ongoing
(ii) To be
commenced
i
ii
iii
iv
v
No action taken
Coordination of Veterinary
Epidemiological Research
on Infectious Diseases in
Europe
MACROSYS
Macrophage systems biology
applied to disease control
A European Academic Network
for Vaccine Research
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Ideas to be transformed into
research projects
1.
2.
3.
4.
5.
Outline of the Presentation.
Introduction
The Action Plan
Danish Proposals
Funding of Proposals
Conclusions
28
ETP Global Animal Health
Action plan: Funding
Sources of funding for the proposals
EC Programs (e.g. FP7, COST, DGs)
• Close consultation with EC, MSs, EP representatives
National research programs- EMIDA
• Providing opportunities to better align and coordinate
national programs. (EMIDA ERA-Net), SCAR
Public/private research partnerships
• Exploring areas of strategic importance in which ambitious
initiatives can be taken
Charities and private non-profit foundations .
All these funding bodies have their own agendas/priorities
that are set independently of each other)
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EC Funding :
Framework 7 Programme 2007 to 2013
Cooperation – Collaborative research €32.342b (€1.944)
Ideas – Frontier Research €7.460b
People – Human Potential €4.728b
Capacities – Research Capacity €4.243b
Cooperation is 64% of budget of FP 7 budget of €50.524 billion
Food, Agriculture & Biotech - €1.944b
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Cooperation – Collaborative research
Joint Technology Initiatives
Collaborative research
(Collaborative projects; Networks of Excellence; Coordination/support actions)
Coordination of non-Community research programmes
(ERA-NET; ERA-NET+; Article 169)
International Cooperation
Small collaborative projects (“small or medium-scale focused research
actions”) are projects with a requested Commission contribution up to € 3 million
Large collaborative projects (“large-scale integrating projects”) and Networks
of Excellence between € 3 million and € 6 million
Coordination and Support Actions (CSA) up to € 1 million
31
Cooperation – Collaborative research
Calls made
Call FP7-KBBE-2007-1:
Publication Date: 22/12/2006: Deadline: 02/5/07
ERA Net, discontools, BTb, ASF, RVF, WNF, CCF
FP7- KBBE-2007-2A:
Publication Date: 15/6/2007, Deadlines: 11/9/07 : stage 2 19/2/08 - Stage 2
(only for proposals retained at stage 1
Wildlife, ICONZ, zoonoses
FP7- KBBE-2008-2B:
Publication Date: 30/11/ 2007: Deadline: 26/2/ 2008.
FMD, CSF
FP7- KBBE-2009-3:
Publication Date: 03/9/2008 : Deadline: 15/1/ 2009
PRRS, Orboviruses, Tick borne diseases, campylobacter
FP7-KBBE-2010-4
Publication Date 30/7/2009 Deadline 14/1/2010
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Swine influenza, Parasites,welfare
FP7 KBBE-2010-4
Activity 2.1: Sustainable production and management of biological resources from land,
forest and aquatic environments
Area Topics called
Funding Schemes
2.1.3
–
KBBE.2010.1.3-01: Development of vaccines and improvement
of detection systems to control helminth parasite infections of
livestock and reservoirs
SICA (Latin America and/or Asia and/or African Mediterranean
Partner Countries and/or African ACP) Collaborative Project (largescale integrating project) for Specific Cooperation Actions Dedicated
to International Cooperation Max. EC contribution/proposal:
EUR 9 000 000
2.1.3
KBBE.2010.1.3-02: Promoting coordination and cooperation at
international level of research programmes in the area of
animal health, in particular infectious diseases
including zoonoses -
Mandatory ICPC (Latin America and Asia) Coordination and Support
Action (coordinating action) Max. EC contribution/proposal:
EUR 1 000 000
2.1.3
KBBE.2010.1.3-03: Development and integration of animal
based welfare indicators in livestock species
Collaborative Project (large scale integrating project) Max. EC
contribution/proposal: EUR 4 500 000
2.1.3
KBBE.2010.1.3-04: Improving integration in farm animal
welfare research in an enlarged Europe
Coordination and Support Action (coordinating action) Max. EC
contribution/proposal: EUR 1 000 000
KBBE.2010.1.3-05: Swine influenza surveillance network
Coordination and support action (coordinating action) Max. EC
contribution per proposal: EUR 1 000 000 Maximum one proposal can
be selected.
KBBE.2010.1.3-06: Pathogenesis and transmission of
influenza in pigs (CP-IP)
Collaborative project (large scale integrating project32) Max. EC
contribution per proposal: EUR 5 000 000 Maximum one proposal can
be selected
33
EC Funding :
Framework 7 Programme 2007 to 2013 :
Cooperation – Collaborative research €32.342b (€1.944)
Ideas – Frontier Research €7.460b
People – Human Potential €4.728b
Capacities – Research Capacity €4.243b
Cooperation is 64% of budget of FP 7 budget of €50.524 billion
Food, Agriculture & Biotech - €1.944b
34
Capacities – Research Capacity
1. Research Infrastructures
2. Research for the benefit of SMEs
3. Regions of Knowledge
4. Research Potential
5. Science in Society
6. Activities of International Cooperation
35
EC Funding :
COST Programme
• COST – together with EUREKA and the
EU framework programmes – is one of the
three pillars of joint European research
initiatives. These three complementary
structures have differing areas of
research.
36
37
38
39
40
41
EC Funding :
Framework 7 Programme 2007 to 2013 :
• The ERA-NET scheme was introduced under FP6
to support the networking of research funding
organisations (programme owners and managers
e.g. government ministries and research councils)
to develop and strengthen the coordination of
national research programmes.
• KBBE-2007-1-3-02: Coordination of European
research in the area of animal health, including
emerging threats, infectious diseases and
surveillance. ERA-Net (SRA 13,35,37,47) (1m€) 3
years 1/4/08
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Member State Funding:
EMIDA ERA-NET
• Coordination of European research in the
area of animal health, including emerging
threats, infectious diseases and
surveillance
• 26 partners in 19 countries and four
associated partners
• Combined research budget in the region of
270 million Euros
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44
Aims of EMIDA
The overall aim of the Animal Health ERANET is to build on and accelerate the work
of the SCAR CWG in developing a durable
focused network of national research
funders in Member and Associated States
of the EU for the purpose of sharing
information, coordinating activities and
working towards a common research
agenda and mutual research funding
activities in the field of animal health.
45
Scope of EMIDA
The scope of the project will include
emerging and major infectious diseases of
production animals, including fish and
bees and including those conditions which
pose a threat to human health but
excluding food safety issues relating to
livestock products and diseases of wildlife,
except where they act as a reservoir of
infection for humans and animals.
46
47
Transnational Calls from EMIDA
• Vectorborne diseases - Development of underpinning
knowledge and tools for early warning, detection &
monitoring and novel control strategies
• Zoonoses and antimicrobial resistance, excluding
microbial safety of products - Development of
underpinning knowledge and tools for early warning,
detection & monitoring and novel control strategies
• Major infectious diseases affecting production
Development of underpinning knowledge and tools for
early warning, detection & monitoring and novel
control strategies, including genetics of resistance
• Aquaculture - Development of underpinning
knowledge and tools for early warning, detection &
monitoring and novel control strategies, particularly
vaccine-based approaches
48
Transnational Calls from EMIDA
•
•
•
•
Pre-announcement flyer www.EMIDA-ERA.NET
Formal Announcement
21 July
Call opens
7 September
Pre-proposal Submission deadline
16 November
• Invitation for full proposals
23 December
• Deadline for full proposals
1 March
• Funding decisions
June 2010
49
Ideas to be transformed into
research projects
1.
2.
3.
4.
5.
Outline of the Presentation.
Introduction
The Action Plan
Danish Proposals
Funding of Proposals
Conclusions
50
Conclusions
Danish Proposals and the Action Plan
Proposals
1. A European Academic
Network for Vaccine
Research
2. Coordination of
Veterinary
Epidemiological
Research on
Infectious Diseases in
Europe
3. Endemic diseases
Action plan
Components in the action
plan, 3.1,,3.3,4.1
Recommended in the
action plan, 3.2
Apart from MUMS not in
the action plan
51
Conclusions
Danish Proposals and the Action Plan
Proposals
1. A European Academic
Network for Vaccine
Research
2. Coordination of
Veterinary
Epidemiological
Research on
Infectious Diseases in
Europe
3. Endemic diseases
Funding
COST
FP7 Collaboration
COST
EMIDA
52
Conclusions.
To be successful any proposals must:• Reinforce leadership at international level,
increase international cooperation
• Early involvement of industry, SMEs
• Contribute to the
– EU Animal Health Strategy
– Development policy and MDGs
– Action Plan ETPGAH
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Mirror groups
54
THANK YOU
55
COST National Coordinators (CNC)
Mr Gorm Bramsnæs
Country representative for Denmark
Ministry of Science, Technology and
Innovation
Bredgade 40
DK-1260 Copenhagen K
Denmark Tel. +45 3544 6343
Fax +45 3544 6201
[email protected]
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