Transcript PPT - EDUCAUSE Library

The NIH Roadmap
for Medical Research
nihroadmap.nih.gov
Evolving Health Challenges
Acute to Chronic Conditions
Aging Population
Health Disparities
Emerging Diseases
Biodefense
Why was there a need for a Roadmap?
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Position NIH to address evolving
public health challenges
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Accelerate the pace of discoveries
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Develop more rapid translation from
laboratories to patients and back
NIH Roadmap Goals..
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Accelerate basic research discoveries and
speed translation of those discoveries into
clinical practice
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Explicitly address roadblocks that slow the
pace of medical research in improving the
health of the American people
NIH opportunities and challenges…
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Revolutionary and rapid changes in science
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Increasing breadth and growth of NIH mission
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NIH is a complex organization made up of 27
institutes and centers, as well as multiple
program offices, structured by Disease,
Organ, Life stage, Discipline ….
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Rapid convergence of science
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Multi- and interdisciplinary research
Multi- and Interdisciplinary Research will be Required to
Solve the “Puzzle” of Complex Diseases and Conditions
Genes
Behavior
Diet/Nutrition
Infectious agents
Environment
Society
???
How was the Roadmap developed?
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Extensive consultations with stakeholders,
scientists, health care providers
Discussions addressed:
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What are today’s scientific challenges?
What are the roadblocks to progress?
What do we need to do to overcome roadblocks?
What can’t be accomplished by any single Institute
but is the responsibility of NIH as a whole?
What is the NIH Roadmap?
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A framework of priorities that the NIH
as a whole must address in order to
optimize its entire research portfolio.
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A set of initiatives that are central to
extending the quality of healthy life for
people in this country and around the
world.
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A vision for a more efficient and
productive system of biomedical and
behavioral research.
Roadblocks
to technology transfer
Bench
Bedside
Public
Three themes emerged….
New Pathways
to Discovery
NIH
Research Teams
of the Future
Re-engineering the
Clinical Research
Enterprise
New Pathways to Discovery
Bench
Bedside
Public
Building Blocks,
Biological Pathways,
& Biological Networks
Molecular Libraries &
Molecular Imaging
Bioinformatics &
Computational Biology
Structural Biology
Nanomedicine
nihroadmap.nih.gov/newpathways/index.asp
New Pathways to Discovery
Initiatives within this theme address
technologies and approaches necessary to
meet contemporary research challenges.
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Grasping the emerging complexity of biology
Understanding biological systems
Accessing biological data, technologies, and other
scientific resources
Promoting Multi-and Interdisciplinary research
Bioinformatics and Computational Biology:
National Centers for Biomedical Computing
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Partnerships of:
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Computer scientists
Biomedical computational scientists
Experimental and clinical biomedical and behavioral
researchers
Focused on software rather than hardware
Each National Center to have Driving Biological
Projects
Programs in preparation for partnerships between
individual investigators and National Centers
www.bisti.nih.gov/ncbc/index.cfm?
The FY-2004 NIH Roadmap National Centers for Biomedical Computing:
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Physics-based Simulation of Biological Structures
Russ Altman, M.D., Ph.D.
Stanford University
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National Alliance for Medical Imaging Computing
Ron Kikinis, M.D.
Brigham and Women's Hospital
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Informatics for Integrating Biology and the Bedside
Isaac Kohane, M.D., Ph.D.
Brigham and Women's Hospital
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Center for Computational Biology
Arthur Toga, Ph.D.
University of California at Los Angeles
Research Teams of the Future
Interdisciplinary
Research Teams
Pioneer Award
Bench
Public-Private Partnerships
Bedside
Public
Building Blocks,
Biological Pathways, &
Biological Networks
Molecular Libraries &
Molecular Imaging
Bioinformatics &
Computational Biology
Structural Biology
Nanomedicine
nihroadmap.nih.gov/researchteams/index.asp
Research Teams of the Future
Initiatives within this theme provides
mechanisms for interdisciplinary research,
high-risk strategies and public-private
partnerships.
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Encouraging Multi- and Interdisciplinary teams
Supporting larger, coordinated, resource sharing teams
Preserving investigator-initiated strategy
Promoting investigators to take creative, unexplored
avenues of research
NIH Director’s Pioneer Award
 New program to support individuals with
untested, potentially groundbreaking ideas!
 Encourages innovation, high risk taking
 Totally new application and peer review process
 Expected to be highly competitive
 Expanded eligibility – (not only traditional
biomedical investigators)
 Provides $500,000 per year for 5 years
nihroadmap.nih.gov/pioneer/
NIH Director’s Pioneer Award
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Laurence F. Abbott, Ph.D., Brandeis University, Waltham, MA
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George Q. Daley, M.D., Ph.D., Children's Hospital, Boston, MA
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Homme W. Hellinga, Ph.D., Duke University Medical Center, Durham, NC
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Joseph McCune, M.D., Ph.D., J. David Gladstone Institutes, San Francisco, CA
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Steven L. McKnight, Ph.D., UT Southwestern Medical Center, Dallas, TX
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Chad Mirkin, Ph.D., Northwestern University, Evanston, IL
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Rob Phillips, Ph.D., California Institute of Technology, Pasadena, CA
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Steven R. Quake, Ph.D., California Institute of Technology, Pasadena, CA
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Sunney Xie, Ph.D.. Harvard University, Cambridge, MA
nihroadmap.nih.gov/pioneer/Recipients04.aspx
Re-engineering the Clinical Research
Enterprise
Interdisciplinary
Research Teams
Pioneer Award
Bench
Building Blocks,
Biological Pathways &
Biological Networks
Molecular Libraries &
Molecular Imaging
Bioinformatics &
Computational Biology
Structural Biology
Nanomedicine
Public-Private Partnerships
Bedside
Public
Clinical Research Networks, & NECTAR
Dynamic Assessment of Patient-Reported
Chronic Disease Outcomes
Clinical Research Policy Analysis &
Coordination
Clinical Research Workforce Training
Translational Research
nihroadmap.nih.gov/clinicalresearch/index.asp
Reengineering the Clinical Research
Enterprise
Initiatives within this theme address the need
for developing new strategies to enhance the
infrastructure and capacity for clinical research
and reenergize the clinical research workforce.
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Promoting better integration of existing clinical research
networks, including the National Electronics Clinical Trials
and Research (NECTAR) network
Supporting translational research
Encouraging the development of technologies to improve
the assessment of clinical outcomes
Harmonizing regulatory processes
Enhancing training for clinical researchers
NIH Roadmap
Percent of Total NIH Budget – FY-2004
FY-2005 Request = $28,757 Million
Non-Roadmap
99.2%
($28,520 Million)
Roadmap
0.8%
($237 Million)
“How does the NIH Roadmap benefit
research funded by NIH ICs?”
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Speeding removal of major and fundamental
roadblocks common to all diseases
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Institutes working together to solve issues
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This is a common trans-NIH pool of
transforming investments open to all disease
areas and all investigators for competition
The NIH Roadmap:
A Work in Progress
nihroadmap.nih.gov