Transcript Presentation Lyme Case study Autism One Lorene Ametx

Lyme Disease in Autism: Diagnosis and Treatment Options
Introduction
Inflammation/ oxydative stress
Diagnosis
Disease paradigm
Antibiotic Treatment
Naturopathic approaches
A parent perspective
www.autismtreatmenttrust.org
www.loreneamet.net
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Lyme Disease Agents
USA: Essentially Borrelia burgdorferi.
Europe: B. afzelii, B. garinii, B. burgdorferi, and occasionally
other species of borrelia
Scanning electron micrograph image of Borrelia burgdorferi. Image-Wadsworth Center, New York State Department of Health
Lyme disease is spread by the bite of ticks of the genus Ixodes (deer tick) that are
infected with Borrelia burgdorferi.
Life cycle of Borrelia is linked to the tick life cycle
Two Year Life-Cycle Deer Tick
Reported Cases of Lyme Disease—United States, 2010. Source CDC
Lyme Disease Symptoms
Early Symptoms
(Acute)
Erythema migrans seen in 50% of people
Less frequently still in EU
Late Symptoms
(Chronic)
“The Great Imitator”
Common symptoms:
Profound fatigue
Chills, sweats ad skin flushes
Migrating arthralgia
Muscle pain/ twitching
Severe headaches
Tremors
Numbness/ Tingling sensations, pain shifting
Cranial nerves disturbances
Cont...
Lyme Disease Symptoms Cont.
Neurological symptoms associated with late stage Lyme disease:
Progressive dementia
Seizure disorders
ALS-like symptoms (similar to Lou Gehrig’s disease)
Gillian-Barre-like symptoms
Multiple Sclerosis-like symptoms
Parkinson’s disease-like symptoms
Other extrapyramidal disorders
Visual disturbances or loss
Loss of attention/ executive functions, auditory and mental tracking and
memory retrieval. These will impact on:
Memory functions
Language functions
Visual and spatial processing
Abstract reasoning
Processing speed
Systemic inflammation
The prolonged immune response, trying to
fight Borrelia burgdorferi infection, causes most
of the symptoms of Lyme disease, including
joint inflammation, skin changes, and
neurological problems.
Spirochete and colony-like Borrelia forms
Characteristic morphology of Borrelia burgdorferi (Dark field microscopy images
of Borrelia burgdorferi strain B31 showing the usual spiral form of spirochetes (A)
and their agglomeration into colony-like masses (B)
Cystic Borrelia forms
Rolled and cystic forms of Borrelia burgdoferi spirochetes observed after one
week of culture in medium to which Thioflavin S had been added.
Intracellular and cystic Borrelia forms
Atypical and cystic Borrelia forms following 1
week exposure of primary neuronal and
astrocytic cultures to Borrelia burgdorferi. C:
OspA positive Borrelia spirochetes closely
surrounding neurons (strain B31). D: Atypical
filamentous and ring-shaped cystic, apparently
intra-cellular spirochetes in a neuron (strain
B31).
Systemic Inflammation in Lyme’s Disease
Chronic neuroinflammation in the
frontal cortex of a patient with
Lyme neuroborreliosis. First column
(A, D and G): Accumulation of HLADR (A) and CD68 (D)
immunoreactive microglia forming
clumps, and GFAP (G) positive large
reactive astrocytes in the frontal
cortex of a patient with Lyme
neuroborreliosis.
Systemic inflammation in Autism
Diagnosis of Lyme
1- Detection of Borrelia agents
PCR, Serology and Elispot
2- Co-infections: Ehrlichia, Babesia, Bartonella, Yersinia, Toxoplasma gondii,
Anaplasma phagocytophilum, and other potential infections that can affect
health: Streptococcus A, Chlamydia, Mycoplasma, Borrelia burgdorferi
2- Clinical symptoms of chronic infection
Sweating, excessive thirst, level of activity, fatigue, body temperature
regulation issues, muscle tones, skin flushing, rash, motor and cognitive
functions, pain, hearing sensitivity.
3- Complementary lab work
Natural Killer cell counts: NK1, NK2, NK3
Complete blood count
Inflammation Markers
Auto-immune issues
Liver/ Kidney function
Nutritional markers
Hormonal profile
The Lyme War
International Lyme And Associated
Diseases Society (ILADS):
Symptoms of Chronic Lyme are real
and associated with remaining Borrelia
Long-term treatment of infection is
required.
Infectious Diseases Society of America
(IDSA), American Academy of Neurology,
Centers for Disease Control and Prevention
NIH, NHS:
Chronic Lyme does not exist.
Advise against long-term antibiotic treatment.
No other treatment considered.
Treatment Options
General points
Remove Stressors
GF/CF –SCD- Sugar etc.
Allergens
Toxins
Optimal metabolism & physiology
Nutrition
Digestion
Immune system
Liver & kidney functions
Hormonal
Treat the Infection
Three Borrelia stages to consider
& Potential co-infections
Example of antibiotic regimen
Heirxheimer reaction proves that inflammation
causes a wide range of behavioural and health
Disturbances
Cholestyramine- Questran ideally version without Aspartame
Activated charcoal
Aspirin
Hydrocortisone (100mg) During AB treatment
Prednisolone during AB treatment
Systemic Enzymes e.g Wobenzymes
Breaks in treatments
Sauna/ detoxification
Other problems associated with prolonged
antibiotic use
•Yeast and clostridia flare ups
•Liver and kidney function
•Heart
•Eye sight
•Drug-drug interaction
Buhner’s protocol
Core protocol
Andrographis Paniculata standardised to 10%
andrographolids
Japanese Knotweed (Resvertrol)
Cat's Claw (uncaria tomentosa)
Astragalus
anti-inflammatory, antibacterial, anti-viral, anti-malarial, vermicidal,
immunostimulant, sedative, hepatoprotective. Crosses blood brain barrier.
Neuroborreliosis, low immune function.
Broadly systemic plant. Acts against a number of Gram + and Gram - bacteria.
Enhahnces blood flow. Co-Infection, Neuroborreliosis. Anti-viral (Herpes etc).
Anti-inflammatory (diminish arachidonic acid pro-inflammatory metabolites and
raises white blood cell count).
immune potentiator, anti-inflammatory, cognition, raises NK cell count, raises
neutrophil cell count., late stages of chronic infection, helps with memory deficit
and relaxes the CNS.
Immune enhancer, modulator, stimulant, antiviral, antibacterial, GI tract. Good for
Lyme residing in an endemic area, chronic fatigue, night sweats, pre and early
Lyme- may not be suitable in late Lyme if auto-immune issues coexist. Ehrlichia
infection. Inhibit NF-KB pathway. Improved issues of memory impairement in
Lyme
Smilax
Systemic plant, Heirxheimer- binds to toxins in the blood, immunomodulatory,
antibacterial, antiv viral, neuroprotective, antioxydant, antifungal, anti fatigue.
Enhences cognitive function. Neuroborreliosis.
Bee Venom
Extending the protocol
Siberian Ginseng (Eleuthero)
Potent antioxidant, antifungal, antibacterial, antiinflammatory
Strongly initiate response to spirochete infection. Immune tonic and potentiator,
adrenal tonic, antidepressant, mental clarity, restore energy levels.
Kalmegh, Lycopodium clavatum also used for epilepsy, Periwinkle (vinpocetine) (V minor, V major), cerebral
blood flow and cognitive function. Red Root (Ceanothus americanus or equivalent) Artemesinin (Artemisia
annua), Autumn crocus (Colchicum autumnale) surijan-i-talkh etc.
Alternative Treatment Options?
Electromedicine –Rifle machine
Mortar Oscillatory Rate (MOR)