Transcript Evaluation of Combination Regimens in GT1

Update on Genetic Links to HCV Clearance
Todd Wills, MD
ETAC Infectious Disease Specialist
HEPATITIS C TREATMENT EXPANSION INITIATIVE
MULTISITE CONFERENCE CALL
FEBRUARY 20, 2013
Percentage of SVR by genotypes for IL-28B region
DL Ge et al. Nature 461, 399-401(2009)
Clinical Correlates of IL28B CC Genotype
• Spontaneous Clearance of HCV infection
• Improved response to interferon based
treatment
• Faster progression to cirrhosis in HIV infection
• Treatment effect less significant with HCV
direct acting antivirals
• Potential role in treatment decisions in acute
HCV infection
Barreiro P et al. J Infect Dis. 2011;203:1629-1636
DL Ge et al. Nature 461, 399-401(2009)
Genetic Loci Associated with Spontaneous Clearance of HCV
Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013.
Conditional Analysis of Allele Effect – HLA and IL28B
Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013.
Clinical Correlates of HLA loci
(DQB1*03:01 )
• Increased rate of HCV spontaneous clearance
• Does not effect response to treatment
• May be associated with preserved HCV
specific proliferative CD4 response
Duggal, P. et al. Annals of Internal Medicine. 158(4):235-245, February 19, 2013.