Transcript Document

Welcome to the genetic ice age in animals.
Remember: Extinction is forever!
July 7, 2015
Dr. Plechner
This will be an introduction to EI
imbalances in animals.
July 7, 2015
Dr. Plechner
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Hopefully
you will
never have
to treat an EI
imbalance
that looks
like this!
July 7, 2015
Dr. Plechner
Why have these EI imbalances
occurred first in animals?
 A genetic
geometric progression of
EI imbalances has occurred.
 Indiscriminate family breeding plus
“designer” animal breeding has
brought the “gene pool” close
enough to cause the EI imbalance.
July 7, 2015
Dr. Plechner
Dogs & cats – live 12-15 years and have multiple offspring.
Horses – live 20 –25 years and +/- have 1-2 offspring.
Humans – live 70 – 75 years and +/- have 1-2 offspring.
July 7, 2015
Dr. Plechner
What is this EI imbalance ?
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The imbalance is the development of deficient or
bound cortisol leading to the high estrogen, which
not only further binds cortisol, but also binds T3T4
leading to a deregulated immune system.
The actual animal EI test is only done on blood
samples.
This includes cortisol, T3 T4, total estrogen & IgA,
IgG & IgM. These are comparative levels, not
emperical levels. The laboratory will give you the
normal ranges versus the level that appears in the
animal.
July 7, 2015
Dr. Plechner
Genetics, aging, medical input and
environment input:
Regulates
Hormones
Regulates
B & T Cells
July 7, 2015
Dr. Plechner
one – The adrenal,
thyroid, pituitary,
hypothalamic axis
normalizes the immune
system in animals.
Figure
July 7, 2015
Dr. Plechner
This schematic shows normal relationships and
feedback activity between the adrenal cortex and the
hypothalamus and pituitary, and in turn, a healthy
regulatory influence on the immune system.
July 7, 2015
Dr. Plechner
two – Cortisol deficiency or
imbalance can lead to anterior
pituitary over-producing ACTH
which leads to an adrenal estrogen
excess which not only binds
cortisol, T3 T4 but deregulates the
immune system in animals.
 Figure
July 7, 2015
Dr. Plechner
Deficient or inactive cortisol triggers a flood of ACTH and adrenal
estrogen. The combination binds remaining cortisol as well as thyroid
hormone, and destabilizes the immune system. Metabolism also slows
as a result of impact on the thyroid.
July 7, 2015
Dr. Plechner
Figure three – replacement therapy
with physiological dose levels of
hydrocortisone and thyroid
hormones restore order to immune
regulation through adrenal, thyroid,
and pituitary hypothalamic axis
resulting in normalization in
animal.
July 7, 2015
Dr. Plechner
Long-term replacement therapy with physiologic doses of
cortisone (and thyroid hormone, as needed) restores order
to the hypothalamus-pituitary-adrenal axis and immune
system.
July 7, 2015
Dr. Plechner
In clinical studies, the guide to
hormonal replacement therapy lies with
normalizing adrenal estrogen and IgA,
IgG & IgM levels through cortisol
thyroid replacement.
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In dogs a
combination of
hydrocortisone and
thyroid supplements
will be used.
July 7, 2015
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In cats, 90% of the EI
cases, hydrocortisone
will be used.
Dr. Plechner
 Remember,
in animals, too little or too
much steroid thyroid replacement may
lead to deregulation of the immune
system.
 In animals, usually the sooner the EI
imbalance occurs, the sooner the disease
begins.
July 7, 2015
Dr. Plechner
What are the diseases that we see in
animals?
 Allergy,
auto immunities, chronic
bacterial, fungal and viral
diseases, retroviral diseases and
cancer.
 Retrovirus are seen mainly in
cats.
July 7, 2015
Dr. Plechner
What are these retrovirus?
Feline
Leukemia
Feline Aids
Feline Infectious Peritonitis.
July 7, 2015
Dr. Plechner
 Does
not occur in cats with normal EI
balance.
 Only occurs in cats with hormonal
imbalances which have led to a
deregulated immune system.
 When the deregulated immune cells
recognize the virus, they kill the virus
and the host.
July 7, 2015
Dr. Plechner
Success
rate with retroviral
diseases.
Felv – 85%
Fiv - 75%
Fip - 70%
July 7, 2015
Dr. Plechner
In a multiple cat household, if one cat has
developed a retrovirus, test the others.
 If negative, watch carefully.
 However, if any of the cats test positive,
then the EI test is done.
 If EI test is normal for example, FIV will
not develop into feline Aids.
 If EI test abnormal, then you correct the
imbalance to stop the development of feline
aids.
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July 7, 2015
Dr. Plechner
 Inflammatory
bowel disease patients all
have EI imbalances with abnormal IgA
levels.
 IgA imbalances relate to most diseases of
the mucous membranes in the body.
 Research has shown the secretory and
circulatory IgA levels are the same
animals.
July 7, 2015
Dr. Plechner
What are some of the IgA imbalanced
diseases:
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July 7, 2015
Periodontal disease
Food sensitivities
Inflammatory bowel disease
Chronic respiratory disease
Chronic kidney and bladder disease
Stinging insect sensitivity
Vaccine reactions
Anaphylaxis
Dr. Plechner
 To
re-regulate the EI imbalance,
if IgA level is below 60g/dL,
injectable steroid will be given at
3-week intervals with thyroid
hormone twice daily. Due to
steroid malabsorption, injectable
steroids are more effective.
July 7, 2015
Dr. Plechner
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When adrenal estrogen approaches normal, so
will IgA. Oral steroid is indicated now.
In a dog & cat, normal range for IgA = 70 –
170mg/dL.
Again remember in an animal, too little or too
much steroid or thyroid will lead to an EI
imbalance.
These animal models are easier to work with
because most female patients have had an ovariohysterectomies.
Further studies have indicated that hormone
levels may be normal but without comparative
test, no one knows if they actually work.
July 7, 2015
Dr. Plechner
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A sluggish metabolism can lead to a hormone
being present in the blood stream at a 36 hour
level as opposed to a 24 hour measurement
level which appear to be normal.
Hemoconcentration may raise hormone levels
and give false normals.
These animal studies indicate that a patient’s
window for hormone replacement relates to
normalizing the immune system.
July 7, 2015
Dr. Plechner
In closing, the hormone replacement
protocol used to treat an EI imbalance is
simple and effective:
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July 7, 2015
Establish initial levels of total estrogen, T3& T4, IgG,
IgM and IgA. (Depending on the patient’s symptons,
other blood tests may be indicated.)
Fund the patients deficiencies with either injectable or
oral steroid and a thyroid supplement.
Re-test hormone and antibody levels and adjust
medication accordingly.
At least annual testing should be done after the patient
has been normalized.
Dr. Plechner