Transcript Application of optical imaging in the detection of tumors

Inexpensive and Accessible
Thermal Imaging for the
Detection of Cancer
Angela Fan
Ben Wang
Mark Bucklin
Nancy Diao
Olufunke Laseinde
A Problem and a Solution
Methods Used to
Screen and
Monitor for Cancer
Current Methods
A Device That
Will:
Measure Skin-Surface
Temperature
Report Topographic
Location
Expensive
Be Inexpensive
Uncomfortable
Inconvenient
Rely on Presence of Tumor not
Growth of Tumor
Software That
Will:
Map and Record Spatial
Temperature Fluctuations
Recognize Patterns of
Carcinoma Development
Common
Detecting Cancer: Current
Methods
Mammography
Self Exam
Ultrasound
Less
Common
MRI
PET/CT
Thermography
From top left, clockwise: Mammogram (Harvey), Breast Self Exam, Ultrasound of the breast (Tiefenbacher), MRI of the breast with T1 contrast and fat reduction (Harvery), Combined
PET and CT (Lavayssiere), Breast Thermogram (http://www.aathermography.com)
Thermography
CMOS Focal Plane
Array Cameras
~10 μm IR
radiation at 36º C
FDA Approved for
Screening Alongside
Mammograms
Particularly good at
screening for
•Breast Cancer
•Pain
•Neurological Disorders
“Breast thermography has an
average sensitivity and
specificity of 90%”
“Breast thermography has the
ability to detect the first signs
that a cancer may be forming
up to 10 years before any other
procedure can detect it.”
“When used as part of a
multimodal approach (clinical
examination + mammography +
thermography) 95% of early
stage cancers will be detected.”
Bronzino, Joseph. The Biomedical
Engineering Handbook. 3rd ed.
©2006. CRC Press. Ch.25
Top to Bottom: Angiogenesis (http://www.gene.com/gene/research/focusareas/oncology/angiogenesis.html), Breast Thermogram
(http://www.thermogramcenter.com/Images.htm)
Similar Devices
Handheld Optical Scanner
Thermal Imaging Camera
Single-Sensor Thermography
System
•Near Infrared Absorbance
•Drexel/Upenn
•In Clinical Trials
Left: Material from Drexel/Upenn device by Chance, B (http://www.biomed.drexel.edu/new04/Content/ProgressReport/fnir_breastcancer.pdf) , Center: Nec TS9100 Thermal Imaging Camera
(www.metrum.co.uk) , Thermal Body Scan (http://thermalbodyscan.com/DITI.aspx). Right: Se Jin Yoon, et. Al. A Study of Thermographic Diagnosis System and Imaging Algorithm
by Distributed Thermal Data using Single Infrared Sensor. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:3319-22.
Design
Specifications/Constraints
Versatile
Power
-Comfortable and Adaptable
-Enough power to run a
complete body scan
Spatially Accurate
-Develop Anatomically
Relevant Temperature Map
Software
-User Friendly GUI
-Pattern Recognition
Design
Specifications/
Constraints
Reliable
-At least 95% accuracy
-Detect temperature
changes of ~0.1˚F
Accessible/Inexpensive
-Lightweight & Handheld
-Home
-Family Physician,
-Humanitarian
Components and Related Products
Position Tracking
Optical Sensor
Temperature Measurement
Thermistor
Optical Sensor
Gyro
Thermopile
Accelerometer
Design Concept #1
Handheld Device
•Thermopiles
•Optoelectronic Sensors
•Gyro/Accelerometer
•IR Tracker
CPU
•Process position
•Display Coverage
•Store Temperature
•Give Directions
•Diagnose via Pattern
Recognition
User
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html
http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #2
Advantages
• Form-fitting, stationary
devices allows the surveyed
area to be easily mapped
• User will be familiar with
and the device form
• Material will be comfortable.
Disadvantages
• Needs to be made for a
variety of breast sizes.
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html
http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #3
Advantages
• No complex tracking
needed since device would
be stationary
• Flexible material is
suitable for a range of
breast sizes
Disadvantages
• May be large, and
unwieldy
• May be uncomfortable
Questions?