Transcript Action potential propagation from real guinea pig

Effects of Ischemia on Discontinuous Action Potential
Conduction in Hybrid Pairs of Ventricular Cells
by Ronald Wilders, E. Etienne Verheijck, Ronald W. Joyner, David A. Golod, Rajiv
Kumar, Antoni C. G. van Ginneken, Lennart N. Bouman, and Habo J. Jongsma
Circulation
Volume 99(12):1623-1629
March 30, 1999
Copyright © American Heart Association, Inc. All rights reserved.
A and B, Cell chamber for application of simulated ischemic conditions.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
A, Po2; B, APD90; and C, RMP for an isolated guinea pig ventricular cell with ischemic
conditions applied for period indicated by horizontal bar.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Action potential propagation from real guinea pig ventricular cell to Luo-Rudy model cell13
under control conditions.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Action potential propagation from real guinea pig ventricular cell to Luo-Rudy model cell,13 in
same format as Figure 3, after 8 minutes of exposure of real cell to ischemic conditions.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Action potential propagation from real guinea pig ventricular cell to Luo-Rudy model cell13
under control versus ischemic conditions.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Action potential propagation from real guinea pig ventricular cell to Luo-Rudy model cell13
under control conditions versus ischemic conditions including norepinephrine.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
A, Critical coupling conductance and B, maximum conduction delay for action potential
propagation from real guinea pig ventricular cell to Luo-Rudy model cell13 under control versus
ischemic conditions (control versus ischemia, n=11) and control conditions versus ischemic
conditions including 1 μmol/L norepinephrine (control versus ischemia+NA, n=8).
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Action potential propagation from real guinea pig ventricular cell to Luo-Rudy model cell13
under control versus ischemic conditions (left) and control conditions versus ischemic
conditions including norepinephrine (right).
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.
Current-voltage relations of single guinea pig ventricular cells after 10 to 15 minutes of exposure
to ischemic conditions: peak current (left) and quasi–steady-state current (right) elicited on 500ms depolarizing voltage clamp steps from holding potentials of −40 and −80 mV, respectively.
Ronald Wilders et al. Circulation. 1999;99:1623-1629
Copyright © American Heart Association, Inc. All rights reserved.