Transcript (NHANES :1999-2004). Source: NCHS and NHLBI.

Cardiovascular Epidemiology:
Definitions
Historical Perspectives and Assessing
Risk of CVD
Recent trends and population
differences in CHD and CHD risk
factors
Deaths in Thousands
500
461
410
400
285
300
265
Males
Females
200
100
70
59
64
35
47 38
0
A
B
A Total CVD
B Cancer
C Accidents
C
D
E
A
B
D
F
E
D Chronic Lower Respiratory Diseases
E Diabetes Mellitus
F Alzheimer’s Disease
Leading causes of death for all males and females
(United States: 2004). Source: NCHS and NHLBI.
52%
13%
.4%
.5%
4%
6%
Coronary Heart Disease
Heart Failure
Diseases of the Arteries
Defects
Rheumatic Fever/
Rheumatic Heart Disease
7%
17%
Stroke
High Blood Pressure
Congenital Cardiovascular
Other
Percentage breakdown of deaths from cardiovascular diseases
(United States:2004)
Source: NCHS and NHLBI.
Deaths in Thousands
1 000
872
900
800
700
555
600
500
400
325
267
300
200
100
0
5 3
4 4
16 15
46 49
<25
25-34
35-44
45-54
78 96
55-64
CVD
130 139
65-74
165
80
75-84
85+
Cancer
Cardiovascular disease deaths vs. cancer deaths by age
(United States: 2004). Source: NCHS and NHLBI.
Total
Development of Atherosclerotic
Plaques
Fatty streak
Normal
Lipid-rich plaque
Foam cells
Fibrous cap
Thrombus
Ross R. Nature. 1993;362:801-809.
Lipid core
Atherosclerotic Plaque Rupture and
Thrombus Formation
Intraluminal thrombus
Growth of thrombus
Blood Flow
Intraplaque thrombus
Adapted from Weissberg PL. Eur Heart J Supplements
1999:1:T13–18
Lipid pool
PDAY: Percentage of Right Coronary Artery Intimal
Surface Affected With Early Atherosclerosis
30
Intimal
surface
(%)
Men
Raised lesions 30
Fatty streaks
20
20
10
10
0
30
0
15-19 20-24 25-29 30-34
White
30
20
20
10
10
0
0
15-19 20-24 25-29 30-34
Black
Age (y)
PDAY= Pathobiological Determinants of Atherosclerosis in Youth.
Strong JP, et al. JAMA. 1999;281:727-735.
Women
15-19 20-24 25-29 30-34
White
15-1920-2425-2930-34
Black
Coronary Remodeling
Progression
Compensatory expansion
maintains constant lumen
Normal
vessel
(Adapted from Glagov et al.)
Glagov et al, N Engl J Med, 1987.
Minimal
CAD
Moderate
CAD
Expansion
overcome:
lumen narrows
Severe
CAD
Most Myocardial Infarctions Are Caused
by Low-Grade Stenoses
Pooled data from 4 studies: Ambrose et al, 1988; Little et al, 1988; Nobuyoshi et al, 1991; and Giroud et al,
1992.
(Adapted from Falk et al.)
Falk E et al, Circulation, 1995.
Vulnerable Versus Stable
Atherosclerotic Plaques
Vulnerable Plaque
Lumen
Fibrous Cap
Lipid
Core
• Thin fibrous cap
• Inflammatory cell infiltrates:
proteolytic activity
• Lipid-rich plaque
Stable Plaque
Lumen
Lipid
Core
Fibrous Cap
Libby P. Circulation. 1995;91:2844-2850.
• Thick fibrous cap
• Smooth muscle cells:
more extracellular matrix
• Lipid-poor plaque
Correlation of CT angiography of the
coronary arteries with intravascular
ultrasound illustrates the ability of MDCT
to demonstrate calcified and non-calcified
coronary plaques (Becker et al., Eur J
Radiol 2000)
Non-calcified, soft, lipid-rich plaque in
left anterior descending artery (arrow)
(Somatom Sensation 4, 120 ml Imeron
400). The plaque was confirmed by
intravascular ultrasound (Kopp et al.,
Radiology 2004)
Features of a Ruptured
Atherosclerotic Plaque
• Eccentric, lipid-rich
• Fragile fibrous cap
• Prior luminal
obstruction < 50%
• Visible rupture
and thrombus
Constantinides P. Am J Cardiol. 1990;66:37G-40G.
Clinical Manifestations
of Atherosclerosis
• Coronary heart disease
–
Stable angina, acute myocardial infarction, sudden
death, unstable angina
• Cerebrovascular disease
–
Stroke, TIAs
• Peripheral arterial disease
–
Intermittent claudication, increased risk of death
from heart attack and stroke
American Heart Association, 2000.
Definitions
• CARDIOVASCULAR DISEASE or CVD
includes CORONARY ARTERY DISEASE
and other cardiac conditions (congenital,
arrhythmias, and congestive heart failure)
• CORONARY ARTERY DISEASE (CAD) or
CORONARY HEART DISEASE (CHD) (often
broadly referred to as ISCHEMIC HEART
DISEASE (IHD): primarily myocardial
infarction and sudden coronary death,
broader definition may include angina
pectoris, atherosclerosis, positive
angiogram, revascularization, and
myocardial infarction
Definitions (cont.)
• REVASCULARIZATION includes coronary
artery bypass graft (CABG), percutaneous
transluminal coronary angioplasty (PTCA),
stent, and atherectomy
• CEREBROVASCULAR DISEASE includes
stroke (ischemic or hemorrhagic) and
transient ischemic attack (TIA)
• PERIPHERAL VASCULAR DISEASE
includes carotid artery disease and
intermittent claudication
• SURROGATE MEASURES include: carotid
intimal medial thickness (IMT), coronary
calcium, angiographic stenosis, brachial
ultrasound flow mediated dilatation (FMD)
92.0
Percent of Population
100.0
71.3 75.1
80.0
83.0
60.0
39.1 39.5
40.0
20.0
14.8
9.4
0.0
20-39
40-59
Males
60-79
80+
Females
Prevalence of cardiovascular diseases in adults age 20 and older
by age and sex (NHANES: 1999-2004). Source: NCHS and NHLBI.
These data include coronary heart disease, heart failure, stroke and hypertension.
Percent of Population
35.0
32.7
30.0
22.8
25.0
20.0
21.6
15.4
15.0
7.8
10.0
5.0
5.5
0.6 0.6
0.0
20-39
40-59
Men
60-79
Women
Prevalence of coronary heart disease by age and sex
(NHANES :1999-2004). Source: NCHS and NHLBI.
80+
Annual Number of Americans Having
Diagnosed Heart Attack by Age and Sex
New and Recurrent Attacks
ARIC: 1987-2000
500,000
410,000
400,000
300,000
372,000
250,000
Men
Women
200,000
100,000
88,000
34,000
10,000
0
29-44
45-64
65+
Ages
Source: Extrapolated from rates in the NHLBI’s ARIC surveillance study,
1987-2000. These data don’t include silent MIs.
Annual Rate of First Heart Attacks
by Age, Sex and Race
ARIC: 1987-2000
Per 1,000 Persons
14
12
10
White Men
8
Black Men
6
White Women
4
Black Women
2
0
35-44
45-54
55-64
65-74
Ages
Source: NHLBI’s ARIC surveillance study, 1987-2000.
Percent of Population
16
14.8
14
12.4
12
10
8
6.5 6.2
6
4
2
0.5 0.5
1.2
2.3
0
20-39
40-59
Men
60-79
80+
Women
Prevalence of stroke by age and sex (NHANES: 1999-2004).
Source: NCHS and NHLBI.
Percent of Population
14
11.6
12
12.4
10
7.2
8
5.2
6
4
2
2
0.3
1.5
0.2
0
20-39
40-59
Men
60-79
Women
Prevalence of heart failure by age and sex
(NHANES: 1999-2004). Source: NCHS and NHLBI.
80+
Discharges in Thousands
700
600
Male
500
Female
400
300
200
100
0
79 80
85
90
95
00
Years
Hospital discharges for heart failure by sex
(United States: 1979-2004). Source: NHDS, NCHS and NHLBI.
Note: Hospital discharges include people discharged alive, dead and
status unknown..
04
Deaths in Thousands
520
500
480
460
440
420
400
380
0
79 80
85
90
95
Years
Males
Females
00
04
Source: NHLBI 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases
____________________________________________________________
Lifetime Risk of Coronary Heart Disease
in the Framingham Study
______________________________________________________________
Men
At age 40 years: 48.6%
At age 70 years: 34.9%
Women
31.7%
24.2%
_________________________________________________________________
Lloyd-Jones et al. Lancet 1999; 353:89-92
____________________________________________________________
First Coronary Events: Framingham
Study
________________________________________________________
Percent as Specified Event
Myocardial
Infarction
Age Men Women
Angina
Pectoris
Men Women
35-64 43% 28%
65-84 55% 44%
41%
28%
59%
41%
Sudden
Death
Men Women
9%
4%
11% 7.4%
____________________________________________________________
Framingham Study 44 year follow-up.
Estimated 10-Year CHD Risk in
55-Year-Old Adults According to Levels
of Various Risk Factors
Estimated 10-Year Rate (%)
Framingham Heart Study
40
35
30
25
20
15
10
5
0
37
27
25
20
Men
Women
13
5
8
5
A
B
C
A
B
D
C
D
Blood Pressure (mm Hg)
120/80
140/90
140/90
140/90
Total Cholesterol (mg/dL)
200
240
240
240
HDL Cholesterol (mg/dL)
50
50
40
40
Diabetes
No
No
Yes
Yes
Cigarettes
No
No
No
Yes
mm Hg = millimeters of mercury
mg/dL = milligrams per deciliter of blood
Source: Circulation 1998;97:1837-1847.
Estimated 10-Year Stroke Risk in 55Year-Old Adults According to Levels of
Various Risk Factors
Estimated 10-Year Rate (%)
Framingham Heart Study
30
27
25
22.4
19.1
20
14.8
15
8.4
10
5
2.6
6.3
5.4
4
3.5
2
1.1
0
A
B
C
D
Men
Systolic BP*
Diabetes
Cigarettes
Prior Atrial Fib.
Prior CVD
A
95-105
No
No
No
No
B
130-148
No
No
No
No
Source: Stroke 1991;22:312-318.
E
F
Women
C
130-148
Yes
No
No
No
D
130-148
Yes
Yes
No
No
E
130-148
Yes
Yes
Yes
No
F
130-148
Yes
Yes
Yes
Yes
*BP in millimeters of mercury (mmHg)
Estimated 10-Year Rate (%)
30
27
25
22.4
Men
20
W omen
19.1
14.8
15
8.4
10
5
2.6
5.4
4
2
1.1
6.3
3.5
0
A
Systolic BP*
Diabetes
Cigarettes
Prior Atrial Fib.
Prior CVD
B
A
95-105
No
No
No
No
C
B
130-148
No
No
No
No
D
C
130-148
Yes
No
No
No
D
130-148
Yes
Yes
No
No
E
E
130-148
Yes
Yes
Yes
No
F
F
130-148
Yes
Yes
Yes
Yes
*BP in millimeters of mercury (mmHg)
Estimated 10-year stroke risk in 55-year-old adults according to levels
of various risk factors (FHS).
Source: Wolf et al., Stroke.1991;22:312-318.
Offspring CVD Risk by Parental CVD Status:
Framingham Study
Parental CVD <55
men, <65 Women
NONE
MATERNAL
PATERNAL
Risk Ratio
2.5
2.5
22
2.2
1.5
1.7
1.7
1.7
11
1.0
1.0
0.5
0.5
00
Men
MEN
Women
WOMEN
Adjusted for: age, total/HDL Chol. ratio, SBP, smoking, diabetes, BMI
Risk imposed by a strong family
history of heart attacks varies widely
depending on the burden of
modifiable risk factors
Multivariable Risk
9
Doubts about
cholesterol as
late as 1989
Risk of Coronary Heart Disease
by Serum Cholesterol
30-Year Follow-up, The Framingham Study
Age-Adjusted Annual Rate per 1000
Serum
Cholesterol
Age: 35-64*
Wome
Men
n
Age: 65-94
Men+
Women*
84-204
8
4
22
11
205-234
13
5
24
15
235-264
14
4
26
17
265-294
15
7
23
17
295-1124
26
10
38
32
*Trends Significant at P.001. +P.07.
Correlation Between Serum
Cholesterol and CVD Mortality
6-Year CVD Death Rate Per 1000
30
Multiple Risk Factor Intervention Trial (MRFIT)
N=325,346
Untreated Patients
25
55-57 years
20
50-54 years
15
45-49 years
10
40-44 years
35-39 years
5
0
Q1
(<182)
Q2
(182-202)
Q3
(203-220)
Q4
(221-244)
Q5
(>244)
Serum Cholesterol Quintile (mg/dL)
Q = serum cholesterol quintile.
Kannel WB et al. Am Heart J. 1986;112:825-836.
_______________________________________________________________________________
Lifetime Risk of CHD Increases with Serum
Cholesterol
___________________________________________________________________________
60
50
Cholesterol
<200 mg
200-239 mg
57
>240 mg
Percent
40
44
30
34
29
20
33
19
10
0
Men
Women
Framingham Study: Subjects age 40 years
DM Lloyd-Jones et al Arch Intern Med 2003; 1966-1972
Percent of Population
45
40
35
30
25
20
15
10
5
0
39.0
32.0 32.0
Total Population
32.0
34.0
NH Whites
Men
32.0 30.0
31.0
NH Blacks
Mexican
Americans
Women
Age-adjusted prevalence of Adults age 20 and older with LDL
cholesterol of 130 mg/dL or higher, by race/ethnicity and sex
(NHANES: 2003-2004). Source: NCHS and NHLBI. NH – non-Hispanic.
Percent of Population
30
25
28
26
25
20
16
13
15
10
9
9
7
5
0
Total
NH Whites
Men
NH Blacks
Mexican
Americans
Women
Age-adjusted prevalence of Adults age 20 and older with HDL
cholesterol <40 mg/dL, by race/ethnicity and sex
(NHANES: 2003-2004). Source: NCHS and NHLBI. NH – non-Hispanic.
Mean Serum Total Cholesterol
208
206
204
206
204
205
204
202
202
202
201
199
200
197
198
196
194
192
NH White
NH Black
1988-94
1999-02
Mexican American
2003-04
Trends in mean total serum cholesterol among adults
age 20 and older, by race/ethnicity, sex and survey
(NHANES : 1988-94, 1999-02 and 2003-04).
Source: NCHS and NHLBI. NH – non-Hispanic.
Mean Total Blood Cholesterol
180
175
171
170
165
160
155
170
165 166
161
163 163
172
166
163 164
174
168
161
156
155
150
145
White Males
Black Males
1976-80
1988-94
White Females
1999-02
Black Females
2003-04
Trends in mean total blood cholesterol among adolescents
ages 12-17 by race, sex, and survey (NHES: 1966-70;
NHANES: 1971-74 and 1988-94). Source: NCHS and NHLBI.
________________________________________________________
CK Friedberg on Hypertension:
Diseases of the Heart 1996
___________________________________________________________
“There is a lack of correlation in
most cases between the severity
and duration of hypertension and
development of cardiac
complications.”
_______________________________________________________________
Relation of Non-Hypertensive Blood
Pressure to Cardiovascular Disease
Vasan R, et al. N Engl J Med 2001; 345:1291-1297
10-year Age- Adjusted Cumulative Incidence
12%
Hazard Ratio*
<120/80 mm Hg
120-129/80-84 mm Hg
130-139/85-89 mm Hg
10%
SBP
10.1
8%
7.6
6%
2%
4.4
2.8
1.9
0%
Women
1.0
1.5
2.5
1.0
1.3
1.6
H.R. adjusted for age,
BMI, Cholesterol, Diabetes
and smoking *P<.001
5.8
4%
<120/80
120-129
130-139
Women Men
Men
Framingham Study: Subjects Ages 35-90 yrs.
Percent of Population
83.8
90.0
80.0
70.0
60.0
50.0
40.0
30.0
20.0
10.0
0.0
73.9
69.5
63.6
55.4
49.1
37.5 37.4
23.2
11.2
18.3
6.4
20-34
35-44
45-54
Men
55-64
65-74
75+
Women
Prevalence of high blood pressure in Adults by age and sex
(NHANES: 1999-2004). Source: NCHS and NHLBI.
Percent of Population
80
70
60
50
40
30
20
10
0
74.6
75.3
62.5
68.4
52.3
39.8
35.8
34.3
24.6
Awareness
Treatment
20-39
40-59
Controlled
60+
Extent of awareness, treatment and control of high blood
pressure by age (NHANES : 1999-2004.) Source: NCHS and NHLBI.
Percent of Population
50
37.5 39.0
40
30
25.6
28.5
38.2
41.4
28.0
26.9 26.2
22.9
25.0
27.0
20
10
0
NH WhiteOnly Men
NH WhiteOnly
Women
NH Black
or AA Men
NH Black
or AA
Women
1988-94
1999-04
Mexican
Men
Mexican
Women
Age-adjusted prevalence trends for high blood pressure in
Adults age 20 and older by race/ethnicity, sex and survey
(NHANES: 1988-94 and 1999-2004). Source: NCHS and NHLBI.
Percent of Population
90
80
70
60
50
40
30
20
10
0
72.9
76.9
63.4
62.4
66.9
49.1
37.2
33.6
25.1
Awareness
NH Whites
Treatment
NH Blacks
Controlled
Mexican Americans
Extent of Awareness, Treatment and Control of High
Blood Pressure by Race/Ethnicity
(NHANES: 1999-2004).
Source: NCHS and NHLBI.
_______________________________________________________________
CK
Friedberg
on
Hypertension
_______________________________________________________________
Diseases of the Heart 1966
“Hypertension imposes a load on
the heart which for many years
may be compensated by left
ventricular hypertrophy”
_______________________________________________________________
CVD Risk Imposed by ECG-LVH
Framingham Study 36-yr. Follow-up
_______________________________________________________________
Age-adjusted
Rate per 1000
Age Men Women
35-64 164
135
65-94 234
235
Risk
Excess Risk
Ratio
per 1000
Men Women Men Women
4.7*** 7.4***
129
117
2.8*** 4.1*** 51
178
_____________________________________________________________
Biennial Rate per 1000. CVD=CHD, stroke,
peripheral vascular disease, heart failure
***P<0.001
____________________________________________________________
Smoking Statement Issued in 1956 by
American Heart Association
___________________________________________________________
“It is the belief of the committee that much
greater knowledge is needed before any
conclusions can be drawn concerning
relationships between smoking and
death rates from coronary heart
disease. The acquisition of such
knowledge may well require the use of
techniques and research methods that
have not hitherto been applied to this
___________________________________________________________
problem.”
CHD Risk by Cigarette Smoking. Filter
Vs. Non-filter. Framingham Study. Men
<55 Yrs.
14-yr. Rate/1000
250
Non-Smoker
Reg. Cig. Smoker
Filter Cig. Smoker
200
206
210
150
100
210
119
112
50
59
0
Total CHD
Myocardial
Infarction
Percent of Population
40
35
30
25
20
15
10
5
0
37.3
33.4
24.1 23.9
20.4 20.2
18.9 17.8
15
11.3
Men
NH White
NH Black
Hispanic
Women
Asian
American Indian or Alaska Native
Prevalence of current smoking for Adults age 18 and older
by race/ethnicity and sex (NHIS:2004).
Source: MMWR. 2004;54:1121-24. NH – non-Hispanic.
Percent of Population
45
40
35
30
25
20
15
10
5
0
24.9
27
24.8
19.2
14
NH Whites
11.9
NH Blacks
Males
Hispanics
Females
Prevalence of high school students in grades 9-12 reporting
current cigarette smoking by race/ethnicity and sex.
(YRBS:2005).Source: MMWR. 2006;55:SS-5. June 9, 2006. . NH – non-Hispanic.
Diseases of The Heart
Charles K Friedberg MD, WB
________________________________________________________________
Saunders Co. Philadelphia, 1949
“The proper control of diabetes is
obviously desirable even though
there is uncertainty as to whether
coronary atherosclerosis is more
frequent or severe in the
uncontrolled diabetic”
______________________________________________________________
Risk of Cardiovascular Events in Diabetics
Framingham Study
_________________________________________________________________
Cardiovascular Event
Coronary Disease
Stroke
Peripheral Artery Dis.
Cardiac Failure
All CVD Events
Age-adjusted
Biennial Rate Age-adjusted
Per 1000
Risk Ratio
Men Women Men Women
39 21
1.5** 2.2***
15
6
2.9*** 2.6***
18 18
3.4*** 6.4***
23 21
4.4*** 7.8***
76 65
2.2*** 3.7***
_________________________________________________________________
Subjects 35-64 36-year Follow-up **P<.001,***P<.0001
13.2
Percent of Population
14.0
12.0
10.7
10.9
11.0
10.0
8.0
6.7
5.6
6.0
4.0
2.0
0.0
Men
NH Whites
Women
NH Blacks
Mexican Americans
Age-adjusted prevalence of physician-diagnosed diabetes in
Adults age 18 and older by race/ethnicity and sex
(NHANES: 1999-2004). Source: NCHS and NHLBI. NH – non-Hispanic.
Deaths/1000 Person Years
50.0
44.1
45.0
40.0
35.0
28.1
30.0
25.0
26.1
21.1
20.0
17.0
15.0
16.7
10.9
10.0
5.0
30.0
2.6
4.3 4.8
6.3
7.8
17.1
14.4
11.5
8.6
No MetS or DM
MetS w/o DM
MetS w/DM
DM only
Prior CVD
Prior CVD and DM
5.3
0.0
CHD Mortality
CVD Mortality
Total Mortality
Mortality rates in U.S. adults, age 30-75, with metabolic syndrome
(MetS), with and without diabetes mellitus (DM) and pre-existing
CVD (NHANES II: 1976-80 Follow-up Study). **
Source: Malik et al., Circulation. 2004;110:1245-50.
** Average of 13 years of follow-up.
Note: Age and gender adjusted.
Skepticism About Importance of Obesity
Keys A, Aravanis C, Blackburn H, et al. Ann Intern Med 1972;
77:15-27.
Concluded that all the excess risk of coronary heart
disease in the obese derives from its atherogenic
accompaniments, illogically leaving the impression that obesity
is therefore unimportant.
Mann GV. N Engl J Med 1974; 291:226-232.
“The contribution of obesity to CHD is either small or
non-existent. It cannot be expected that treating obesity is
either logical or a promising approach to the management of
CHD”.
Barrett-Connor EL. Ann Intern Med 1985; 103:1010-1019
NIH consensus panel is equivocal about the role of
obesity as a cause of CHD.
Relation of Weight Change to Changes in
Atherogenic Traits: The Framingham Study
Frantz Ashley, Jr. and William B Kannel
J Chronic Dis 1974
“Weight gain is accompanied by atherogenic alterations in
blood lipids, blood pressure, uric acid and carbohydrate
tolerance.”
“It seems reasonable to expect that correction of overweight
will improve the coronary risk problem.”
“Avoidance of overweight would seem a desirable goal in the
general population if the appalling annual toll from disease
is to be substantially reduced.”
Risk Factor Sum and Obesity
Framingham Study
Risk Factor Sum
3
2.4
1.8
(1971-74) and (1989-93)
(1989)
(1971)
Risk factors accumulate with weight gain
1.2
0.6
0
Q1
Thin
Q2
Q3
Q4
Risk variables include bottom quintile for HDL-C and top
quintiles for cholesterol, SBP, triglycerides and glucose
Q5
Obese
Overall
Wilson PWF, & Kannel WB
Nutr Clin Care 1999; 1:44-50
Percent of Population
40
34
30.2
30
26
20.6
20
10.7
12.2
15.7
12.8
16.8
17.1
10
0
Men
1960-62
Women
1971-74
1976-80
1988-94
2001-2004
Age-adjusted prevalence of obesity in Adults ages 20-74 by
sex and survey
(NHES, 1960-62; NHANES, 1971-74, 1976-80, 1988-94 and
2001-2004). Source: Health, United States, 2006, unpublished data. NCHS.
Note: Obesity is defined as a BMI of 30.0 or higher.
Percent of Population
20
18
16
14
12
10
8
6
4
2
0
18.7
16.3
11.6
11
6.6
6.4
4.3
3.6
6-11
1971-74
12-19
1976-80
1988-94
2001-2004
Trends in prevalence of overweight among U.S. children and
adolescents by age and survey
(NHANES, 1971-74, 1976-80, 1988-94 and 2001-2004).
Source: Health, United States, 2006, unpublished data. NCHS.
Percent of Population
24
21.3
20
16
15.2
16.1
15.9
12.1
12
8.2
8
4
0
Males
NH Whites
Females
NH Blacks
Hispanics
Prevalence of overweight among students in grades 9-12
by race/ethnicity and sex (YRBS: 2005). Source: BMI 95th
percentile or higher. MMWR. 2006 55: No. SS-5. NH – non-Hispanic.
Percent of Population
45.7
50
40
30
37.5
34.2
26.4
27.0
32.5
25.0
39.6
33.9
31.5
24.0
28.3
23.8
21.6
20.4
18.4
20
34.4
44.8
36.3
31.8
10
0
NH
W
te
hi
M
e
al
NH
k
ac
l
B
M
e
al
Hi
ic
n
a
sp
M
e
al
de
n
sla
e
al
rM
I
ka
s
ii c
f
a
c
Al
a
/
/P
an
i
n
ia
nd
.I
As
Am
e
M
e
al
tiv
a
N
NH
W
te
hi
m
Fe
e
al
NH
k
ac
l
B
m
Fe
e
al
Hi
ic
n
a
sp
cif
a
P
n/
a
i
As
1994
e
al
m
Fe
ic
I
de
n
sla
Am
.I
em
F
r
e
al
a
e
iv
t
Na
...
k
as
l
A
n/
a
i
nd
2004
Prevalence of leisure-time physical inactivity among adults age
18 and older by race/ethnicity, and sex. (BRFSS: 1994 and 2004).
Source: MMWR, 2005;54:No. 39. NH – non-Hispanic.
Percent of Population
50
45
40
35
30
25
20
15
10
5
0
46.9
NH White
38.2
NH Black
Hispanic
39
30.2
26.5
21.3
Male
Female
Sex and Race/Ethnicity
Note: “Currently recommended levels” is defined as activity that increased
their heart rate and made them breathe hard some of the time for a total of
at least 60 minutes/day on 5 or more of the 7 days preceding the survey.
Prevalence of students in grades 9-12 who met currently recommended
levels of physical activity during the past
7 days by race/ethnicity and sex (YRBS: 2005).
Source: MMWR. 2006;55:No. SS-5. NH – non-Hispanic.
International Comparisons in
CVD Morbidity and Mortality
• CVD accounts for 25-45% of deaths
among different countries
• CVD death rates (per 100,000)
range from 1310 in Russia to 201 in
Japan (6.5 fold difference) in men
and from 581 in Russia to 84 in
France (7-fold difference)
• USA ranks 16th for both men (413)
and women (201)
Secular Trends in CHD and
Stroke Mortality
• From 1985-1992, greatest annual
decline (6-7%) in CHD seen in Israel
among men and France among
women, USA intermediate (4%),
increases in Poland and Romania.
• Stroke death rates declined most in
Australia, Italy, and France (8-9%),
USA about 3%.
Age-Adjusted Death Rates for Coronary Heart Disease by Country and Sex,
Ages 35-74, 1999
•Age-Adjusted to European Standard
•Data for 1999 unless noted
Source: NHLBI 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases
Age-Adjusted Death Rates for Stroke by Country and Sex, Ages 35-74, 1999
•Age-Adjusted to European Standard
•Data for 1999 unless noted
Source: NHLBI 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases
Change in Age-Adjusted Death Rates for Coronary Heart Disease by Country and
Sex, Ages 35-74, 1990-1999
Men
Women
•Age-Adjusted to European Standard
•Latest data year note in parentheses
Change in Age-Adjusted Death Rates for Stroke by Country and Sex, Ages 35-74,
1990-1999
Men
Women
•Age-Adjusted to European Standard
•Latest data year note in parentheses
Source: NHLBI 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases
Migrant Studies
• Ni-Hon-San Study showed
Japanese living in Japan to have
the lowest cholesterol levels and
lowest rates of CHD, those living in
Hawaii to have intermediate rates
for both, and those living in San
Francisco to have the highest
cholesterol levels and CHD
incidence
Approaches to Primary and
Secondary Prevention of
CVD
• Primary prevention involves prevention
of onset of disease in persons without
symptoms.
• Primordial prevention involves the
prevention of risk factors causative o
the disease, thereby reducing the
likelihood of development of the
disease.
• Secondary prevention refers to the
prevention of death or recurrence of
disease in those who are already
symptomatic
Risk Factor Concepts in
Primary Prevention
• Nonmodifiable risk factors include age,
sexc, race, and family history of CVD,
which can identify high-risk populations
• Behavioral risk factors include sedentary
lifestyle, unhealthful diet, heavy alcohol
or cigarette consumption.
• Physiological risk factors include
hypertension, obesity, lipid problems,
and diabetes, which may be a
consequence of behavioral risk factors.
Population vs. High-Risk
Approach
• Risk factors, such as cholesterol or blood
pressure, have a wide bell-shaped distribution,
often with a “tail” of high values.
• The “high-risk approach” involves
identification and intensive treatment of those
at the high end of the “tail”, often at greatest
risk of CVD, reducing levels to “normal”.
• But most cases of CVD do not occur among the
highest levels of a given risk factor, and in fact,
occur among those in the “average” risk group.
• Significant reduction in the population burden
of CVD can occur only from a “population
approach” shifting the entire population
distribution to lower levels.
Pyramid of Risk
(Werner et al. Canadian Journal of
Cardiology 1998; 14(Suppl) B:3B-10B)
Expected Shifts in Cholesterol Distribution
from High-Risk, Population, and
Combined Approaches
Population and CommunityWide CVD Risk Reduction
Approaches
• Populations with high rates of CVD are those with
Western lifestyles of high-fat diets, physical
inactivity, and tobacco use.
• Targets of a population-wide approach must be
these behaviors causative of the physiologic risk
factors or directly causative of CVD.
• Requires public health services such as
surveillance (e.g.,BFRSS), education (AHA,
NCEP), organizational partnerships (Singapore
Declaration), and legislation/policy (Anti-Tobacco
policies)
• Activities in a variety of community settings:
schools, worksites, churches, healthcare
facilities, entire communities
A conceptual framework for public
health practice in CVD prevention.
(From Pearson et al., J Public Health. 2001; 29:69 –78)
Communitywide CVD
Prevention Programs
• Stanford 3-Community Study (1972-75)
showed mass media vs. no intervention in
high-risk residents to result in 23% reduction
in CHD risk score
• North Karelia (1972-) showed public education
campaign to reduce smoking, fat
consumption, blood pressure, and cholesterol
• Stanford 5-City Project (1980-86) showed
reductions in smoking, cholesterol, BP, and
CHD risk
• Minnesota Heart Health Program (1980-88)
showed some increases in physical activity
and in women reductions in smoking
Materials Developed for US
Community Intervention
Trials
•
•
•
•
•
•
•
•
•
Mass media, brochures and direct mail
Events and contests
Screenings
Group and direct education
School programs and worksite
interventions
Physician and medical setting programs
Grocery store and restaurant projects
Church interventions
Policies
Individual and High-Risk
Approaches
• Primary Prevention Guidelines (1995) and
Secondary Prevention Guidelines (Revised 2001)
released by the American Heart Association
provide advice regarding risk factor assessment,
lifestyle modification, and pharmacologic
interventions for specific risk factors
• Barriers exist in the community and healthcare
setting that prevent efficient risk reduction
• Surveys of CVD prevention-related services show
disappointing results regarding cholesterollowering therapy, smoking cessation, and other
measures of risk reduction
• Examination:
Presentation
– Height: 6 ft 2 in
– Weight: 220 lb (BMI 28
kg/m2)
– Waist circumference: 41
in
– BP: 150/88 mm Hg
– P: 64 bpm
– RR: 12 breaths/min
• Cardiopulmonary exam:
normal
• Laboratory results:
–
–
–
–
–
TC:
220 mg/dL
HDL-C: 36 mg/dL
LDL-C: 140 mg/dL
TG:
220 mg/dL
FBS: 120 mg/dL
Risk Assessment
Count major risk factors
• For patients with multiple (2+) risk
factors
– Perform 10-year risk assessment
• For patients with 0–1 risk factor
– 10 year risk assessment not required
– Most patients have 10-year risk <10%
ATP III Assessment of CHD Risk
For persons without known CHD, other forms of
atherosclerotic disease, or diabetes:
• Count the number of risk factors:
– Cigarette smoking
– Hypertension (BP 140/90 mmHg or on
antihypertensive medication)
– Low HDL cholesterol (<40 mg/dL)†
– Family history of premature CHD


CHD in male first degree relative <55 years
CHD in female first degree relative <65 years
– Age (men 45 years; women 55 years)
• Use Framingham scoring for persons with 2
risk factors* (or with metabolic syndrome) to
determine the absolute 10-year CHD risk.
(downloadable risk algorithms at
www.nhlbi.nih.gov)
Expert Panel on Detection, Evaluation, and Treatment of
High Blood Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Assessing CHD Risk in Men
Step 1: Age
Years
20-34
35-39
40-44
45-49
50-54
55-59
60-64
65-69
70-74
75-79
Step 4: Systolic Blood Pressure
Points
-9
-4
0
3
6
8
10
11
12
13
Systolic BP
(mm Hg)
<120
120-129
130-139
140-159
160
Points
Points
if Untreated if Treated
0
0
0
1
1
2
1
2
2
3
HDL-C
(mg/dL)
60
Points
-1
50-59
0
40-49
1
<40
2
Age
Total cholesterol
HDL-cholesterol
Systolic blood pressure
Smoking status
Point total
Step 7: CHD Risk
Step 2: Total Cholesterol
TC
Points at
at Points at
(mg/dL)
Age 20-39
70-79
<160
0
160-199
4
200-239
7
240-279
9
280
11
Step 3: HDL-Cholesterol
Step 6: Adding Up the Points
Points at
Points at
Points
Age 40-49 Age 50-59 Age 60-69 Age
0
3
5
6
8
0
2
3
4
5
0
1
1
2
3
0
0
0
1
1
Step 5: Smoking Status
at
Points at
Points at
Age 20-39
70-79
Nonsmoker
0
from
the experience8of
Smoker
Points at
Point Total 10-Year Risk
Risk
<0
<1%
0
1%
1
1%
2
1%
3
1%
4
1%
5
2%
6
2%
7
3%
8
4%
9
5%
10
6%
Points at
Point Total 10-Year
11
12
13
14
15
16
17
8%
10%
12%
16%
20%
25%
30%
Points
Age 40-49 Age 50-59 Age 60-69 Age
0
0
Note: Risk estimates were derived
the Framingham
Heart Study,
5
3
a predominantly Caucasian population in Massachusetts, USA.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.
JAMA. 2001;285:2486-2497.
0
1
0
1
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Assessing CHD Risk in Women
Step 4: Systolic Blood Pressure
Step 1: Age
Systolic BP
(mm Hg)
<120
120-129
130-139
140-159
160
Years
Points
20-34
-7
35-39
-3
40-44
0
45-49
3
50-54
6
55-59
8
60-64
10
65-69
12
70-74
14
75-79
16
Step 2: Total Cholesterol
TC
Points at
at Points at
(mg/dL)
Age 20-39
70-79
<160
0
160-199
4
200-239
8
240-279
11
13
Step 280
3: HDL-Cholesterol
HDL-C
(mg/dL)
60
Points
-1
50-59
0
40-49
1
<40
2
Step 6: Adding Up the Points
Points
Points
if Untreated if Treated
0
0
1
3
2
4
3
5
4
6
Age
Total cholesterol
HDL-cholesterol
Systolic blood pressure
Smoking status
Point total
Step 7: CHD Risk
Points at
Points at
Points
Age 40-49 Age 50-59 Age 60-69 Age
0
3
6
8
10
0
2
4
5
7
0
1
2
3
4
0
1
1
2
2
Step 5: Smoking Status
at
Points at
Points at
Age 20-39
70-79
Nonsmoker
0
Smoker
from
the experience9of
Points at
Point Total 10-Year Risk
Risk
<9
<1%
9
1%
10
1%
11
1%
12
1%
13
2%
14
2%
15
3%
16
4%
17
5%
18
6%
19
8%
Points at
Point Total 10-Year
20
21
22
23
24
25
11%
14%
17%
22%
27%
30%
Points
Age 40-49 Age 50-59 Age 60-69 Age
0
0
7
4
Note: Risk estimates were derived
the Framingham
Heart Study,
a predominantly Caucasian population in Massachusetts, USA.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.
JAMA. 2001;285:2486-2497.
0
2
0
1
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 1: Age
Men
Years
20-34
35-39
40-44
45-49
50-54
55-59
60-64
65-69
70-74
75-79
Women
Points
-9
-4
0
3
6
8
10
11
12
13
Years
20-34
35-39
40-44
45-49
50-54
55-59
60-64
65-69
70-74
75-79
Points
-7
-3
0
3
6
8
10
12
14
16
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 2: Total Cholesterol
Men TC
Points at
Points at
Points at
Age 20-39
Age 40-49
Age 50-59
Age 60-69
0
4
7
9
11
0
3
5
6
8
0
2
3
4
5
0
1
1
2
3
TC
(mg/dL)
Points at
Age 20-39
Points at
Age 40-49
Points at
Age 50-59
<160
160-199
200-239
240-279
280
0
4
8
11
13
0
3
6
8
10
0
2
4
5
7
at
(mg/dL)
70-79
<160
160-199
200-239
240-279
280
Points at Points
Age
0
0
0
1
1
Women
79
Points atPoints at
Age 60-69 Age 700
1
2
3
4
0
1
1
2
2
Note: TC and HDL-C values should be the average of at least two fasting
lipoprotein measurements.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 3: HDL-Cholesterol
Men
HDL-C
(mg/dL)
60
Women
Points
-1
HDL-C
(mg/dL)
60
Points
-1
50-59
0
50-59
0
40-49
1
40-49
1
<40
2
<40
2
Note: HDL-C and TC values should be the average of at least two
fasting lipoprotein measurements.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 4: Systolic Blood Pressure
Men
Systolic BP
Points
(mm Hg) if Untreated
<120
0
120-129
0
130-139
1
140-159
1
160
2
Points
if Treated
0
1
2
2
3
Women
Systolic BP
(mm Hg)
<120
120-129
130-139
140-159
160
Points
Points
if Untreated if Treated
0
0
1
3
2
4
3
5
4
6
Note: The average of several BP measurements is needed for an accurate
measurement of baseline BP. If an individual is on antihypertensive treatment,
extra points are added.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 5: Smoking Status
Men
at
70-79
Nonsmoker
Smoker
Points at
Points at
Age 20-39 Age 40-49
Points at
Points at Points
Age 50-59
Age 60-69
0
1
0
8
0
5
0
3
Points at
Points at
Points at
Age
0
1
Women
at
70-79
Nonsmoker
Smoker
Age 20-39 Age 40-49
0
9
Points at Points
Age 50-59
Age 60-69
0
4
0
2
0
7
Age
0
1
Note: Any cigarette smoking in the past month.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 6: Adding Up the Points
(Sum From Steps 1–5)
Age
Total cholesterol
HDL-cholesterol
Systolic blood pressure
Smoking status
Point total
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
ATP III Framingham Risk Scoring
Step 7: CHD Risk for Men
Point Total
Risk
<0
0
1
2
3
4
5
6
7
8
9
10
10-Year Risk
Point Total
<1%
1%
1%
1%
1%
1%
2%
2%
3%
4%
5%
6%
11
12
13
14
15
16
17
10-Year
8%
10%
12%
16%
20%
25%
30%
Note: Determine the 10-year absolute risk for hard CHD (MI and
coronary death) from point total.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
What is WJC’s 10-year absolute
risk
of fatal/nonfatal MI?
• A 12% absolute risk is derived from points
assigned in Framingham Risk Scoring to:
–
–
–
–
–
Age:
6
TC:
3
HDL-C:
2
SBP:
2
Total: 13 points
In 1992 he exercised 14 minutes in a Bruce protocol exercise
stress test to 91% of his maximum predicted heart rate without
any abnormal ECG changes. He started on a statin in 2001.
But in Sept 2004, he needed urgent coronary bypass surgery.
ATP III Framingham Risk Scoring
Step 7: CHD Risk for Women
Point Total
Risk
<9
9
10
11
12
13
14
15
16
17
18
19
10-Year Risk
Point Total
<1%
1%
1%
1%
1%
2%
2%
3%
4%
5%
6%
8%
20
21
22
23
24
25
10-Year
11%
14%
17%
22%
27%
30%
Note: Determine the 10-year absolute risk for hard CHD (MI and
coronary death) from point total.
Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. JAMA. 2001;285:2486-2497.
© 2001, Professional Postgraduate Services®
www.lipidhealth.org
CHD Risk Equivalents
• Risk for major coronary events
equal to that in established CHD
• 10-year risk for hard CHD >20%
Hard CHD = myocardial infarction + coronary
death
Diabetes as a CHD Risk
Equivalent
• 10-year risk for CHD  20%
• High mortality with established CHD
– High mortality with acute MI
– High mortality post acute MI
CHD Risk Equivalents
• Other clinical forms of
atherosclerotic disease (peripheral
arterial disease, abdominal aortic
aneurysm, and symptomatic carotid
artery disease)
• Diabetes
• Multiple risk factors that confer a 10year risk for CHD >20%