Transcript AHA Branded Blue Presentation

American Heart Association
Texas Affiliate
Brent Fields
Vice President
Research Administration &
State Health Alliances
Research
AHA Top Priority
The AHA believes that learning more about the #1 and #3 killers in
America is one of the best ways to accomplish our mission:
Impact Goal: By 2010, we will reduce coronary heart disease, stroke
and risk by 25 percent.
The AHA’s commitment to research is
reflected in our strategic plan:
1. Increasing the capacity of the
research community to generate
the highest quality research;
2. Identifying critical research
agendas and increasing the
understanding of specific
cardiovascular issues.
Research Expense
for
Major National Health Agencies: 2004
A American Cancer Society
$140
B Alzheimer’s Association
$120
C American Diabetes Association
$100
$80
D National Multiple Sclerosis
Society
$60
E March of Dimes
$40
F Muscular Dystrophy
Association
$20
G Juvenile Diabetes Association
$0
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H American Heart
Association
AHA’s 2004-05
EXPENDITURES
Management
& General
7%
Community
Services
7%
Research
23%
Professional
Educ &
Training
12%
Fundraising
15%
AHA National Budget Expenditures
Public Health
Education
36%
How each dollar is spent
75¢
25¢
Donor Dollar
National Center
13.5¢
Texas Affiliate
Research
Allocation
28.5%
15¢
Nobel Prize Recipients funded by
AHA
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1937 – Dr. Albert Szent-Gyorgyi
1971 – Dr. Earl Sutherland
1985 – Dr. Joseph Goldstein
1985 – Dr. Michael Brown
1992 – Dr. Edwin Krebs
1998 – Dr. Robert Furchgott
2003 – Dr. Peter Agre
Milestones
1956 - Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first links dietary fat with
cholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to
change their eating habits.
1956 - Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful
ending of ventricular fibrillation in humans by externally applied countershock.
1957 - Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs.
Vincent Gott and Walter Lillehei, implants the first externally powered pacemaker in a patient
with a surgical heart blockage.
1960 - Dr. Albert Starr performs the first long-term successful mitral valve replacement with a caged
ball valve, ushering in a new era of valve replacement. He was supported in developing the
artificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards.
1961 - Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with
the aid of a microscope. Microsurgery ultimately leads to changes in coronary artery surgery,
plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor
surgery.
1985 - Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are
awarded the Nobel Prize in Physiology or Medicine for their research on the role of lowdensity lipoprotein receptors in controlling blood cholesterol levels. Their research provides
new insights into the ways fatty cholesterol enters body cells and why cholesterol levels may
become too high.
Texas Research Statistics
• FY 06-07 there are currently 154 Texas Researchers funded by the
AHA
(TX Affiliate = 96; National = 58)
• FY 06-07 total amount funded =$9,152,708
(TX Affiliate = $4,974,265; National = $4,178,443)
• 2000-2008 total funding = $67,993,077
(TX Affiliate = $36,611,162; National $31,381,915)
• Currently 11 cities and 22 institutions are represented by funded
researchers in Texas
• 100+ Texas researchers participated in our TXA Peer Review in
2006
• There are currently 15 Research Allocations and
Advisory Committee Members (RAAC)
Galveston Statistics
University of Texas Medical Branch
TXA Applications received/funded for the 2006 cycle = 13/2
TXA Applications received/funded 2000-2006 = 100/19
7 Active Researchers = TXA - 6; National – 1
410,500 in Active AHA grants (FY 06-07 actual spent)
(TXA - $345,500; National - $65,000)
$3,728,376 in AHA funding (2000-2008 allocated)
(TXA - $2,355,981; National - $1,372,395)
Current Research Allocations & Advisory Committee Members
Paul Boor, MD – Professor, Dept. of Pathology
Galveston Statistics
University of Texas Medical Branch
Texas Affiliate – Currently Funded Researchers
2005-07 Kishor Bhakat, PhD
Beginning Grant-in-Aid
Role of Human AP-endonuclease (APT1/Ref-1) in Regulation of Blood
Pressure
2005-07
Perenlei Enkhbaatar, MD, PhD
Beginning Grant-in-Aid
Role of nitric oxide in pathogenesis of cardiopulmonary derangements in
sepsis induced by smoke inhalation and pnemonia
2005-07
Luis Ruess, MD
Grant-in-Aid
Architecture of the Pore of Connexin43 Channels and Hemichannels
2005-07
Bruns Watts lll, PhD
Beginning Grant in Aid
Regulation of Renal Transport by Neurotropins
2006-08
Michael Kinsky, PhD
Beginning Grant in Aid
Pharmacologic Modulation of Fluid Therapy
2006-08
Sutapa Ray, PhD
Beginning Grant in Aid
STAT3 Signaling in Acute Phase Response
Galveston Statistics
University of Texas Medical Branch
National Center – Currently Funded Researchers
2006-09
Sanjeev Choudhary, PhD
Scientist Development Grant
Novel Role of the NF-kB inducing kinase in Respiratory Syncytial Virus
infection
Research Focus
• Training and career development of
beginning scientists
• Support of cutting edge basic and
clinical science
What Kinds of Research
Do We Support?
The AHA supports research that is
broadly related to the cardiovascular area
and stroke.
SCIENCE AREAS
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Basic Cell and Molecular Biology
Behavior Science, Epidemiology & Prevention
Bioengineering & Biotechnology
Brain
Cardiac Biology/Regulation
Cardiac Electrophysiology &
Arrhythmias/Regulation
Cardiorenal
Cardiovascular Development
Cell Transort, Physiology & Metabolism
Immunology and Microbiology
Liporproteins, Lipid Metabolism & Nutrition
Lung, Respiration & Resuscitation
SCIENCE AREAS
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Molecular Signaling
Radiology & Imaging
Surgery
Thrombosis
Vascular Biology & Blood Pressure/Regulation
Vascular Wall Biology
Programs Offered by AHA
National Center
• Scientist Development Grant
January and July Application Deadline for January
and July activation
• Fellow to Faculty Grant
January and July Application Deadline for
January and July activation
• Established Investigator Award
July Application Deadline for January activation
Programs Offered by the
Texas Affiliate
• Postdoctoral Fellowship
January application deadline for July activation
• Beginning Grant-in-Aid
January application deadline for July activation
• Grant-in-Aid
January application deadline for July activation
Postdoctoral Fellowship
To provide stipend support to help trainees initiate careers in
cardiovascular and stroke research, and further research training while
obtaining significant research results.
(2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded)
Deadline: January 4, 2007
Award:
$30,000 - $46,000 stipend, depending on years of training or experience,
plus annual $3,000 departmental allowance.
Term:
1 or 2 years. May apply for competitive one-year award.
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Full-time research effort and sincere interest in pursuing a career in
cardiovascular related research expected.
Applicant must hold a doctoral degree and have less than 6 years of post doctoral
research training and experience at award activation (July 1, 2007).
Support is limited to work within non-profit institutions in Texas.
Institutional supplementation permissible under certain conditions.
An investigator may sponsor no more than two Affiliate Post Doctoral Fellows at any
one time. Any application for a new award that would exceed this limit will not be
reviewed.
Each of the following criteria will be considered:
– The applicant
– The sponsor’s qualifications
– The environment and training program resources
– The specific research project
Beginning Grant-in-aid
To Promote the Independent Status of Promising Beginning Scientists by
Supporting High Quality, Well-defined Research Projects in the
Cardiovascular Area, Including Stroke.
(2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded)
Deadline: January 4, 2007
Award:
$65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI
salary, including fringe benefits.
Term:
2 years. Competitive renewal is possible for up to four years of
support.
Applicants must have:
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an MD, PhD, DO, DVM, or equivalent doctoral degree.
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A faculty appointment or equivalent academic or research track position, up to
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and including a rank of assistant professor, by the time of award activation (July 1, 2007).
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The applicant must meet institutional requirements for submission of an extramural, peer
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reviewed grant proposal.
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No more than 7 years of active faculty appointment prior to award activation (July 1, 2007).
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No more than $100,000 of all extramural grant support per year, excluding principal
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investigator and collaborating investigators salaries, fringe, and intramural funding
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Each of the following criteria will be considered:
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Evidence the award will promote the independent status of the applicant
Scientific excellence of the proposal
Qualifications of the applicant, including relevant experience, familiarity with published work in the
field and productivity
Adequacy of the available resources, including research facilities and institutional environment
Grant-in-aid
To Support the Most Innovative and Meritorious Research Projects From
Independent Investigators in the Cardiovascular Area, Including Stroke.
(2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded)
Deadline: January 4, 2007
Award:
$65,000 per year maximum, including 10% overhead. Up to $15,000
annually for PI salary, including fringe benefits.
Term:
2 years. (One year requests are exceptional, but allowed)
Continuous support of any one investigator is limited to 4 years
Applicants must have:
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An MD, PhD, DO, DVM, or equivalent doctoral degree
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A faculty appointment or equivalent academic or research track position, up to and including a rank of
assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional
requirements for submission of an extramural, peer reviewed grant proposal.
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No more than $200,000 of all extramural grant support per year, excluding principal investigator and
collaborating investigators salaries, fringe, and intramural funding
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Grants will not be awarded to supplement or duplicate any work that is being supported by other
funding agencies. The only exceptions are career development awards.
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The scientific merit – with emphasis on the innovative nature of the proposal – is the most important
factor.
Other Criteria include:
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The presence of new or original ideas
Clear statement of research
Sufficient experimental detail in the research plan
Understanding of the essential methodology
Adequacy of the experimental design
2006
Success Rate – Texas Affiliate
Program
Applications
Funded
%
Postdoctoral
51
8
16
Beginning Grant
90
21
23
Grant-in-Aid
78
16
21
Totals
219
45
21
Awards Funded = 45 ($5,314,314)
11 cities – 18 institutions (New 2006 Awards)
(RAAC allocations from May, 2006 Committee Meeting)
2006
Success Rate – National Center
Program
Pharmaceutical
Roundtable Award –
Career Development
in Implementation
Scientist
Development Grant
Established
Investigator Award
Totals
Applications
Funded
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5
1
20
61
15
25
12
6
50
78
22
28
Awards Funded = 22 ($7,500,000)
7 cities – 7 institutions
(National allocations to Texas for January & July 2006)
American Heart Association
Texas Affiliate
2006-07 Funding Outcomes / Critical Funding Gap1
% Success
Number of
Worthy,
Unfunded
Applications
Additional
Dollars
Needed2
8
16%
14
$1,048,000
42
21
23%
21
$2,730,000
78
36
16
21%
20
$2,723,996
219
100
45
21%
55
$6,501,996
Program
Number of
Applicants
Number of Applicants
in
Fundable range
Number of
Applicants
Funded
Postdoctoral
Fellowship
51
22
Beginning
Grant-in-Aid
90
Grant-in-Aid
Total
Amount committed
to TXA
$5,314,314
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Established at May TX RAAC meeting for new awards activated July 1.
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Additional dollars required to fund meritorious proposals which could not be funded due to insufficient
resources
Peer Review Structure
Western Review Consortium
Texas Affiliate
Research
Committee
Consortium
Steering
Committee
Peer Review
Committees
(10)
WSA
Research
Committee
Peer Review Study Groups
2006-07
•Brain, Cardiorenal, Lung, Respiration, Surgery
•Behavioral Science, Epidemiology & Prevention,
•CV Regulation, Cardiac (Patho) Physiology, Radiology &
Imaging
•CV Development, Immunology & Microbiology, Basic Cell &
Molecular Biology
•Lipoproteins & Lipid Metabolism, Thrombosis, Vascular Wall
Biology
•Cell Transport and Metabolism,
•Cellular CV Physiology & Pharmacology, Molecular Signaling
Life Cycle of a Research Application
Hmm
…
An idea begins
Peer Review
Committee
Application
submitted
Rankordered list
Assigned to
reviewers
Critique
developed
Research
Committee
$ Funded
Reports
Published
Findings
translated
Yea!
E-mail
notification
Research
completed
The Process
Texas Affiliate
January
•Application Deadline
•Applications assigned
to Committees
February
March
•Committee Chairs
review assignments
•Paper copies are sent
to reviewers
•Committee Chairs
finalize assignments
•Reviewers input
preference
April
•Peer Review
Committee meets
May
•Research Committees
meet
•Award Notification
September: online applications are available
October: institutional tour to promote program
July
•Award activation
Other AHA Scientific Products
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AHA Professional Membership/Scientific
Council
Scientific Statements/Guidelines
Scientific Sessions, Conferences and Workshops
AHA Scientific Journals
My.Americanheart.org
QUESTIONS?
For Assistance Contact:
Brent Fields
VP, Research Administration
512-433-7103 – Phone
Rhonda Jennings
Administrative Assistant, Research Administration
512-433-7108 – Phone
512-433-7260 – fax
[email protected]