Transcript Antimicrobial Copper

Copper Alloys and Microbial Ecosystems
Harold Michels, PhD, PE
Copper Development Association
MetaSUB Summit, New York City, June 20, 2015
80% of infectious diseases transferred by touch*
*TIERNO, P. (2001): The Secret Life of Germs. Atria Books: New York, NY, USA.
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Germs can survive on surfaces for a long time
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Rotavirus: 60 days
VRE: 4 months
Acinetobacter spp: 5 months
C.diff spores: 5 months
MRSA: 7 months
E. coli: 16 months
S. typhimurium: 4.2 years
1) KRAMER, A., SCHWEBKE, I. & KAMPF, G. 2006. How long do nosocomial pathogens persist on inanimate
surfaces? A systematic review. BMC Infect Dis. 6:130.
What is Antimicrobial Copper? A family of EPARegistered copper alloys that intrinsically kill bacteria
Solid, copper-based metal
alloys (e.g. brass, bronze)
Durable environmental
surfaces
Bent, formed,
welded, cast,
stamped, etc.
Not a coating or surface treatment!
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0 minutes
30 minutes
60 minutes
120 minutes
Stainless
Steel
31,300,000 CFUs
26,899,425 CFUs
25,933,468 CFUs
21,066,000 CFUs
Antimicrobial
Copper
Antimicrobial Efficacy: E. Coli O157:H7
31,400,000 CFUs
1,600,000 CFUs
2,740 CFUs
<0.1% CFUs
Epifluorescence Images after Staining with Viability Fluorophore CTC
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MRSA Count on Copper and Stainless Steel
After 8 Inoculations Over 24 Hours
Three required test protocols
C110
Stainless Steel
Bacteria Count (CFU/carrier)
 Efficacy
1.00E+08 as a Sanitizer
 Does it kill bacteria?
1.00E+07
 Residual
1.00E+06 Self-Sanitizing Activity
 Is the antimicrobial property a
1.00E+05
permanent effect?
1.00E+04
 Continuous Reduction of Bacteria
 1.00E+03
Will it still clean after
repeated contamination?
1.00E+02
0
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Time (hours)
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Norovirus unable to infect host cells after 2 hours
exposure to copper surfaces at room temperature
Stainless steel
Infectious virus recovered
from stainless steel surfaces
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Copper
No infectious virus recovered
from copper surfaces
Warnes SL, Keevil CW (2013) Inactivation of Norovirus on Dry Copper Alloy Surfaces. PLoS ONE
8(9): e75017. doi:10.1371/journal.pone.0075017
Clinical Testing of Antimicrobial Copper
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Antimicrobial copper components in Memorial
Sloan Kettering Cancer Center
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Bacteria decreased by 83% on copper surfaces
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Schmidt et al. J Clin Microbiol 2012;50(7):2217-2223.
Patients treated in ICU rooms with copper
surfaces had significantly fewer infections
Copper Rooms: 10 HAIs in 294 patients
Control Rooms: 26 HAIs in 320 patients
Normalize populations = 24 Infections in control rooms
= 14 Infections prevented in copper rooms
= 58% reduction in HAI (N=614, p=0.013)
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Salgado et. al. Copper surfaces reduce the rate of healthcare-acquired infection in the intensive care
unit. Infection Control and Hospital Epidemiology, Vol. 34, No. 5, May 2013, pp. 479-486
Investigating impact of copper surfaces on
Healthcare Associated Infections over 1 year
Do dirty surfaces cause HAIs?
Can copper surfaces reduce HAIs?
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Contaminated surfaces increase infection risk
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Salgado et. al. Copper surfaces reduce the rate of healthcare-acquired infection in the intensive care
unit. Infection Control and Hospital Epidemiology, Vol. 34, No. 5, May 2013, pp. 479-486
Grand Central Terminal
New York City
How long will copper alloys retain their
antimicrobial properties?
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Grand Central Station, New York City
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Brass retains antimicrobial efficacy
throughout its lifetime
563 CFU/100cm2
1,866 CFU/100cm2
88 CFU/100cm2
51 CFU/100cm2
60+ year old brass hardware and railings
Grand Central Station, New York City
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While hospitals are the obvious place to focus, Antimicrobial
Copper has many benefits to offer beyond the healthcare sector
Industries where microbial contamination is a major issue and where antimicrobial surfaces have a role to play
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MEDICAL & HEALTHCARE
PUBLIC BUILDINGS
PUBLIC TRANSPORT
Healthcare Associated
Infections are costing society
thousands of lives and billions
of dollars
Viruses caught in public
buildings and malls are costing
society millions of sick days
Viruses caught in public buses
and trains are costing society
millions of sick days
SCHOOLS
FOOD & HOSPITALITY
SPORTS FACILITIES
Viruses caught in schools and
day care are costing society
millions of sick days
Bacteria and viruses picked up
in hotels and restaurants are
costing lost business and
society millions of sick days
Viruses caught in gyms, leisure
centers and locker rooms are
costing society millions of sick
days
These are just some of
the environments where
microbes, including
bacteria, viruses, molds
and fungi are costing
money and lives today.
Details of the other
environments are
contained on our website.
Thank you
Harold Michels, PhD, PE
[email protected]
(212) 251-7224
www.copper.org
www.AntimicrobialCopper.com
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