Transcript BioSeal CVC Powder

Today’s Technology
to Keep Access Sites
Dry and Intact
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The Challenge
A major source of catheter-related infection is soiled,
wet or loose dressings caused by bleeding or oozing
at insertion sites and/or diaphoresis.
The Centers for Disease Control (CDC)
Guidelines for Prevention of Intravascular
Catheter-Related Infections include
recommendations to:
 Replace catheter-site dressing if the dressing
becomes damp, loosened, or visibly soiled;
therefore, keep catheter site dry and intact.
 Replace dressings used on short-term CVC
sites every 2 days for gauze dressings and at
least every 7 days for transparent dressings.
Site without BioSeal CVC
– soiled dressing
Site with BioSeal CVC –
Dry/intact dressing 07days
Photos by Penny Offer, CRNI
How do you keep access sites dry and intact?
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The Solution: BioSeal CVC Powder
BioSeal CVC Powder, formerly PRO QR Powder, is a topical
powder that forms an occlusive seal to stop the flow of blood and
exudates and keep microbes from entering the site.
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The ingredients are a
mixture of a hydrophilic
polymer and a potassium
ferrate.
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BioSeal CVC Powder is not
a vasoconstrictor, or a
cauterizing agent. It is nonsystemic, non-toxic and it is
not biologically derived.
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Proven Efficacy
Results from a product trial** of BioSeal CVC (PRO QR) usage for 418
PICC lines at a large Florida hospital:
Time to Hemostasis (including patients with
clotting difficulties)
Elimination of 24-48 hour dressing change
(first dressing change at 7 days)
Total reported complications
Reduction in Catheter-Related Bloodstream
Infections (CRBSIs)
≤ 2 minutes in
96% of
applications
100%
0
40%
**Trial results on file at Biolife.
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How Does the Powder Work?
 The mechanism of action is a simultaneous
two-step action whereby the hydrophilic
polymer rapidly dehydrates the blood and
absorbs exudates while the potassium ferrate
binds with the blood proteins to create an
occlusive seal.
 As the blood becomes dehydrated, the
“nothing in, nothing out” seal thickens until
blood and nutrient-rich exudates can no
longer permeate through the seal. The seal
creates a hostile barrier to microbes on the
distal side, while maintaining a neutral
environment on the proximal side.
BioSeal CVC Powder
Actual scanning electron
microscopy (SEM) image
For more on the mechanism of action, see the
video at:
http://www.youtube.com/watch?v=00bcKWOFTrs
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The Difference is the Seal
Seal
Extra
powder
The seal:
 Allows “nothing in/nothing out”
 Keeps sites dry and intact
 Minimizes complications from
bleeding/exudate leakage
 Eliminates unnecessary dressing
changes
 Fits all sizes of lines or tubes
 Increases patient satisfaction
SEM photography of a 5 Fr. Catheter.
Note the occlusive seal that has
formed around the line.
Seal the site, don’t just patch it.TM
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BioSeal Creates a Sustained Hostile Environment
Above the Seal
• Bacteria, full of water and salts, come in contact
with the BioSeal CVC powder on the top side of the
seal. (H20 & Ca++, Na+, K+)
• The bacteria dries (desiccation)
• The moisture pulled from the bacteria contain salts.
The cations of these salts are exchanged for H+
(acidic), creating a low pH environment (~2) above
the seal.
The Seal
• Composed of coagulated blood components
• Below the seal the pH is ~ neutral
• Above the seal the pH is ~ 2
Below the Seal
The BioSeal CVC Powder floats on the blood, therefore it
doesn’t penetrate the seal. This results in a neutral pH
below the seal. (The pH below the seal was measured @
7.4 in a saline extraction of a laboratory-created seal.)
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Key Applications
Use BioSeal CVC Powder with the following devices to
stop bleeding and oozing and protect the site:
Vascular Devices: (insertions and removal)
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PICCs/Midlines
Central Venous Catheters
Dialysis Catheters
Arterial Catheters (maintenance)
Also effective in controlling bleeding and exudate
leakage from Non-Vascular Devices such as:
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Peritoneal dialysis catheters
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Epidural catheters
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Large-bore needles used for paracentesis,
thoracentesis, or biopsies
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PEG/Gastrostomy feeding tubes
Photo by Penny Offer, CRNI
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BioSeal CVC Application – Tips for
Success
Do’s:
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To ensure success, secure the line with securement device
before applying powder
Apply firm pressure for two minutes directly over wound
with dry, gloved fingers or non-adherent dressing to form
the protective seal and achieve hemostasis.
Roll fingers off of site to release pressure
Leave seal over wound; the “BioSeal” will fall off naturally
on its own, or if needed, may be removed with sterile
technique.
Pour
Powder
Hold
Pressure
Don’ts:
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Do not hold pressure over BioSeal powder with gauze to
avoid tearing the seal (use dry, gloved fingers instead).
Do not check for hemostasis before the recommended
holding time complete. This could disturb the strengthening
seal.
Seal is
formed
Photos by Penny Offer, CRNI
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Additional Clinical Studies
Further clinical studies have been completed and data
is available for the following BioSeal CVC Powder
applications:
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Vascular Access (arterial and venous)
Mohs Surgery
Wound dehiscence
Ask your sales representative for further information
including clinical references.
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Educational Tools
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Brochures for Patients and Medical Staff
Posters
Protocols
Computer-based Learning Modules
Other support at www.biosealcvc.com
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BIOSEAL CVC Ordering Information
Order Number
Product Description
LP606
6 Applications per Box*
LP636
24 Applications per
Case*
* Each application includes bottle, PCD, product
description label and Patient Discharge
Instructions.
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More Biolife Products
Other Biolife product offerings include:
BioSeal Advanced

Biolife’s powder technology
that controls external
bleeding from arterial
access procedures
PRO QR for Nosebleeds

Topical powder that stops
anterior nosebleeds and
other hard to reach wounds
in a convenient package
with an applicator
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For More Information
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Call Biolife at 800-722-7559
Visit www.biosealcvc.com
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