Transcript Table 4. The Revised Bethesda Guidelines for Testing Colorectal

Table 4. The Revised Bethesda Guidelines for Testing Colorectal Tumors for
Microsatellite Instability (MSI)
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Colorectal cancer diagnosed in a patient who is less than 50 years of age.
Presence of the synchronous or metachronous colorectal cancer or other
HNPCC – associated tumors*, regardless of the age.
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Colorectal cancer with the MSI-H, histology, diagnosed in a patient who is less
than 60 years of age.
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Colorectal cancer diagnosed in one or more first-degree relatives with HNPCC
related tumor*, with one of the cancer being diagnosed under the age of 50
years.
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Colorectal cancer diagnosed in two or more first- or second -degree relatives
with HNPCC- related tumors regardless of the age.
*colorectal carcinoma, endometrial carcinoma, and other related cancer: small bowel,
transitional cell carcinoma of the upper urinary tract, stomach, ovarian, brain( Turcot
syndrome) and sebaceous gland adenomas or keratoachantomas ( Muir-Torre sundrome).
MSI-H, microsatelite instability-high in tumors refers to changes in equal or more than 2 of
the 5 national cancer institute (NCI)-recommended panels.
HNPCC, hereditary nonpolyposis colorectal cancer