Transcript 3.4.4.P UnderstandingNanodevices. pptx

Understanding Cancer and Related Topics
Understanding Nanodevices
Developed by:
Jennifer Michalowski, M.S.
Donna Kerrigan, M.S.
Jeanne Kelly
Brian Hollen
Explains nanotechnology and its potential
to improve cancer detection, diagnosis,
and treatment. Illustrates several
nanotechnology tools in development,
including nanopores, quantum dots, and
dendrimers.
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What Is Nanotechnology?
Water
molecule
Nanodevices
Nanopores
Dendrimers
Nanotubes
Quantum dots
Nanoshells
White
blood cell
A period
Tennis ball
Nanotechnology Plays by Different Rules
Normal Scale
Nanoscale
Designing Nanodevices for
Use in the Body
Too Small
Too Big
Manufacturing Nanodevices
X-ray
beam
Crystal
Crystal
Scattered
X-rays
Detector
Nanodevices
Atoms
in crystal
White
blood cell
Nanodevices Are
Small Enough to Enter Cells
Cell
Nanodevices
Nanodevices
Water
molecule
White
blood cell
Nanodevices Can Improve Cancer
Detection and Diagnosis
Nanotechnology
Imaging
Physical Exam,
Symptoms
Nanodevices Can Improve Sensitivity
Nanodevices
could potentially
enter cells
Precancerous cells
Normal cells
and determine
which cells are
cancerous or
precancerous.
Precancerous cells
Normal cells
Nanodevices Can
Preserve Patients’ Samples
Traditional Tests
Cells from patient
Cells altered
Active state lost
Nanotechnology Tests
Cells from patient
Cells preserved
Active state preserved
Additional tests
Nanodevices Can Make Cancer Tests
Faster and More Efficient
Patient A
Patient B
Cantilevers Can Make Cancer Tests
Faster and More Efficient
Cancer cell
Antibodies
with proteins
Antibodies
Bent cantilever
Water
molecule
White
blood cell
Nanodevices
Cantilevers
Nanopores
Single-stranded
DNA molecule
A
T
C
G
Nanopore
Singlestranded
DNA
molecule
A
Nanopore
T
Nanopore
Single-stranded
DNA molecule
Water
molecule
Nanodevices
Nanopores
White
blood cell
Nanotubes – Marking Mutations
Cancer cell
DNA
Bulky
molecule
tag
Mutation
Cancerassociated
changes
are tagged
with bulky
molecules.
Water
molecule
Nanodevices
Bulky molecule tag
White
blood cell
Nanotubes – Mapping Mutations
Nanotube
A nanotube
traces the
shape of the
DNA and
makes a map.
Water
molecule
Nanodevices
Nanotube
White
blood cell
Quantum Dots
Ultraviolet
light off
Quantum dot
bead
Water
molecule
Ultraviolet
light on
Quantum
dots
Nanodevices
Quantum dots
Quantum dots
emit light
White
blood cell
Quantum Dots Can
Find Cancer Signatures
Quantum dot beads
Cancer cells
Healthy cells
Cancer cells
Quantum dot beads
Healthy cells
Improving Cancer Treatment
Traditional Treatment
Drugs
Nanotechnology Treatment
Toxins
Nanodevices
Cancer
cells
Cancer
cells
Noncancerous cells
Dead
cancer
cells
Dead noncancerous cells
Toxins
Noncancerous cells
Dead
cancer
cells
Intact noncancerous cells
Nanoshells
Near-infrared light off
Nanoshell
Near-infrared light on
Gold
Nanoshell absorbs heat
Water
molecule
Nanodevices
Nanoshells
White
blood cell
Nanoshells as Cancer Therapy
Nanoshells
Nanoshells
Cancer cells
Cancer
cells
Healthy cells
Healthy cells
Near-infrared light
Dead cancer cells
Intact healthy cells
Nanodevices as a Link Between
Detection, Diagnosis, and Treatment
Traditional
Cancer Treatment
Nanotechnology
Cancer Treatment
Cancer cell
Cancer cell
Nanodevice
Drug
Imaging
Reporting
Detection
Targeting
Dendrimers
Cancer cell
Dendrimer
Water
molecule
Nanodevices
Dendrimer
White
blood cell
Dendrimers as Cancer Therapy
Therapeutic
agent
Cancer
detector
Cell death
monitor
Reporter
Water
molecule
Nanodevices
Dendrimer
White
blood cell
Nanotechnologies in Patient Care
Today
2020
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