Transcript The Myc Transcription Factor

The Myc Transcription
Factor
By: Michael Reisfeld
MYC Was Originally cloned
From a transforming Virus
Myc is a Transcription Factor Which
Dimerizes With a Leucine Zipper and
binds to DNA Via a Helix-Loop-Helix
Myc is part of pathway that
promotes Cell Proliferation
Myc Targets a Huge Array of
Genes to Perform This Function
Myc is a Family
of Three
Proteins, in
Which Each
Possesses a
Slightly
different
Function
Overexpression of Each Specific Myc Protein Is
Responsible for Corresponding Tumor Types
Neuroblastoma (N-myc)
Burkitt’s Lymphoma (c-myc)
Small Cell Lung Cancer (L-myc)
c-Myc Overexpression Can Induce
Tumors
A More
Human
Side…
Burkitt’s Lymphoma
• 2% of Lymphoproliferative Disorders
• C-myc translocation associated with ALL cases
– 85% involve translocation to IGH
Is Myc a Viable Target for
Treatment?
Works Cited
Bellan, C et al. “Burkitt’s lymphoma: new insights into molecular pathogenesis.” Journal of Clinical Pathology. 11 July 2002; 56:3, 188-192.
Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, et al. ”Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved
in growth, cell cycle, signaling, and adhesion.” Proc Natl Acad Sci USA. 2000; 97(7):3260-5.
Dalla-Favera R, et al. “Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).” Proc Natl Acad
Sci U S A. 1982;79:6497–501
Ellwood-Yen, Katherine et al. “Myc-driven murine prostate cancer shares molecular features with human prostate tumors.” UClA.
Hatton, Kimi S et al. “Expression and Activity of L-Myc in Normal Mouse Development.” Molecular and Cellular Biology. 1996; 16:4, 1794-1804
Henriksson, Marie and Marina Vita. “The Myc oncoprotein as a therapeutic target for human cancer.” Seminars in Cancer Biology. 2006; 16, 318-330
Laurenti, Elisa et al. “Hematopoietic Stem Cell function and Survival Depend on c-myc and N-myc activity.” Cell Stem Cell. 4 Dec 2008; 3:6, 611-624
Nesbitt, Chad et al. “Myc Oncogenes and human neoplastic disease.” Oncogene. 13 May 1999; 18:19, 3004-3016
Penn, Linda Z and Amanda R. Wasylishen. “Myc: The Beauty and the Beast.” Genes and Cancer. 26 July 2010;
1:6, 532-541
Wey, Alice et al. “c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development.” Cerebellum. Dec 2010; 9:4, 537-547
http://www.thepoultrysite.com/publications/6/diseases-of-poultry/203/myelocytomatosis
.http://www.scripps.org/articles/1391-neuroblastoma
http://www.aboutcancer.com/LUNG_CANCER_PET_8_06._2.pg.jpg