Transcript Presentation1 Dr samah semary

Oncothermia, i. e. the loco-regional deep electrohyperthermia system is a fast-developing supportive,
complementary treatment method against different
types of tumors. The principles are based on the
classical method of hyperthermia, but the aim, beside
the absolute increase in temperature, is especially the
direct electric-field energy absorption in the
extracellular liquid and destroying the membrane of
the cancer cells. Oncothermia's effect is synergic to
radiotherapy and to numerous chemotherapies.
Furthermore, it leads to an increased immunogenicity
and effectively reduces the pain of the patient.(1)
Oncothermia: how the method works and how it is used
A modulated electric field with a carrier frequency of 13.56
MHz is generated by two active electrodes. Since malignant
tissue has higher conductivity than healthy human tissue, the
electric field tends to flow predominantly through the
malignant tumor tissue. The combination of deep layer
heating and the electric field leads to stimulation of
malignant tumor cells. This, in turn, triggers increased
apoptotic activity in the tumor region and as a result,
promotes cell death.
Compared with classic Hyperthermia, which can result in
burns, Oncothermia works at a significantly lower
temperature.
Oncothermia achieves a greater effect at just 38°C-42°C.
Thanks to the selection at cellular level, the radiation only has
an effect in the region of the tumor (2)
Oncothermia achieves a long lasting increase of the
temperature in the extracellular liquid of the tumour
tissue. Due to the constant energy-supply, a
temperature gradient (temperature trap) between the
extra- and intracellular electrolytes develops until the
thermal equilibrium is reached at the end of the
therapy. This (in absolute numbers very low)
temperature difference acts on the likewise small
distance through the cellular membrane (from extra- to
intracellular) and that leads to a destabilizing thermal
stress on the membrane of the tumour cells, leading
those into apoptosis.(3)
Hyperthermia as a complementary method
The most active regions of a tumor and regions far
from blood supply are usually severely hypoxic and
therefore radiation has reduced efficacy in these
regions. The possible vasodilation caused by
hyperthermia aids the synergy via the overall increased
blood perfusion (oxygenation) creating considerable
sensitization to ionizing radiation.
Chemotherapy drugs are delivered into the tumor
through the blood circulation, therefore, it is most
effective in the regions near arterioles. In this respect,
chemotherapy is similar to radiation therapy in that it
primarily targets regions of high blood perfusion due
to the oxygen-rich conditions, then the region which is
more distant from the fresh blood perfusion is less
cooled, so treated effectively by hyperthermia,
completing the treatment of the chemotherapy treated
volume, the thermo-chemotherapy results in a better
therapeutic effect and increases the target specificity as
well as reducing systemic side effects.
Hyperthermia successes:
Summary of the results obtained in Japan by capacitive
hyperthermia combined with radiotherapy.
Brain tumors treated by hyperthermia:
Lung and bronchus:
Some successful clinical trials in combination with
radiotherapy have shown the feasibility of the
hyperthermia method for non-small cell lung cancer.
Capacititive hyperthermia in combination with
radiotherapy was also successful for locally advanced
non-small lung cancer (5) the complete remission rate
was 26% and 0% with and without hyperthermia,
respectively.
Hepatocellular carcinoma and metastatic tumors of the
liver.
References :
(1)Keszler G, Csapo z, Spasokoutskaja T et al (2000) Hyperthermia increases the
phoshorylation of deoxycytidine in the membrane phospholipid precursors and
decrease its incorporation into DNA. AdvExper Med Biol 486:333-337.
(2)Szasz, Andras; Szasz, Nora; Szasz, Oliver (2010-12-03). Oncothermia: Principles
and
Practices.
Springer.ISBN
978-90-481-9497-1.
http://books.google.com/books?id=Ek-2nEe1HpwC. Retrieved 31 July 2011.
(3)Andocs G, Szasz O, Szasz A (2009). "Oncothermia treatment of cancer: from the
laboratory to clinic".ElectromagnBiol Med 28 (2): 148–65. PMID 19811397.
(4)Wismeth c.,Hirschmann B., Pascher C., Dudel C., Szaaz A.,Bogdahn U., Hau
P.:Transcranial electro- hyperthermia combined with alkylating chemotherapy in
patients with relapsing high-grade gliomas-phase I clinical results; Expanding the
Frontiers of thermal Biology, medicine and Physics Annual Meeting of Society of
Thermal Medicine, Tucsan, AZ. USA. 2009
(5)Karasawa K, Muta N, Nakagawa K et al (1994) Thermoradiotherapy in the
treatment of locally advanced non-small cell cancer. Int J radiatOncolBiolPhys
30(5): 1171-1177
(6)Dan A., Clinical experience of electro-hyperthermia for advanced lung tumors,
ESHO Conference, Munich, june2003Ferrari VD, De Ponti S, Valcamonico F,
Amoroso V, Grisanti S, ran goni G, Marpicati P, Vassalli L, Simoncini E, Marini
G:Deep electro-hyperthermia (EHY) with or without thermo-active agents in
patients with advanced hepatic cell carcinoma: phase ll study, Joumal of Clinical
Oncology,25:18S,15168,2007