Transcript March 26th Powerpoint

Day Date Subject To be read prior to this class period:
Th
3/12
Chapter 7
T
3/17
students = epigenetics Richie
Th
3/19
students = toxicology and cancer Anna, Bouradee
T
3/24
Th
3/26
T
3/31
no class - Spring Break
Th
4/2
no class - Spring Break
T
4/7
students = life cycles
Th
4/9
Chapter 9
second short writing assignment due at the start of class on Thurs, 4/9
T
4/14
students = nutrients and development Meg, Zeb
Th
4/16
T
4/21
students = evolution Greg
Th
4/23
Chapter 10
T
4/28
Th
4/30
Capstone Papers due
Chapter 8
T
5/5
Discussion of Capstone Papers
Th
5/7
Chapter 8
Comprehensive Final Exam, Thursday, May 7th, 8:00 – 10:00 AM
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second short writing assignment for your Capstone project:
1)Describe your career goals.
2)Describe you past, current, and future career plans and efforts.
3) Explain which college course has had the most impact on your
career plans and why (not this class).
4) Connect your career goals, plans, and efforts with your Capstone
project efforts in as many ways as you can. These can be similarities
and/or differences.
5) What kind of sources/references could be include in this writing?
Incorporate at least five sources/references.
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correlation of adult blood pressure and birth rate:
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Molecular mechanism might be in the kidney?
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There are many examples of maladaptive responses in Chapter 7
plus new examples that aren’t maladaptive.
maladaptive = a misinterpretation of the environment
Dutch Hunger Winter
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epigenetics
toxicology and cancer
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epigenetics (narrow definition) = DNA methylation and/or
histone modification
DNA methylation stories:
1) promoter of the glucocorticoid receptor
2) thrifty phenotype in mammmals
3) folic acid (methyl donor) in obesity of agouti rats
4) queen ants
5) transgenerational
6) Richie’s paper on the “methylome”
imprinting
embryonic stem cells
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research article Richie selected
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epigenetics
toxicology and cancer
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Cancer
traditional and dominant view: Cancer is caused my DNA mutations.
Carcinogens are carcinogenic because they are mutagens.
This is the somatic mutation hypothesis.
Mutations in oncogenes and tumor suppressor genes are
correlated with cancers and have often been shown to cause cancer.
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Cancer
traditional and dominant view: Cancer is caused my DNA mutations.
Carcinogens are carcinogenic because they are mutagens.
This is the somatic mutation hypothesis.
Mutations in oncogenes and tumor suppressor genes are
correlated with cancers and have often been shown to cause cancer.
Our authors explore a possible new addition:
Some cancers may be caused in part by altered epigenetic
modifications (DNA methylation and histone modifications).
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Cancer
traditional and dominant view: Cancer is caused my DNA mutations.
Carcinogens are carcinogenic because they are mutagens.
This is the somatic mutation hypothesis.
Mutations in oncogenes and tumor suppressor genes are
correlated with cancers and have often been shown to cause cancer.
Our authors explore a possible new addition:
Some cancers may be caused in part by altered epigenetic
modifications (DNA methylation and histone modifications).
epigenetic progenitor model
tissue organization field hypothesis
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Ch 7: Epigenetic origin of adult disease
page 270:
aging lead to increased methylation
aging and random epigenetic drift
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Ch 7: Epigenetic origin of adult disease
page 270:
aging lead to increased methylation
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Ch 7: Epigenetic origin of adult disease
page 270:
aging lead to increased methylation
aging and random epigenetic drift
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Fetal Origins of Adult Disease model
or perhaps a better term for this would be:
Developmental Origin of Health and Disease
The Environmental Mismatch Hypothesis =
A PAR incorrectly anticipates a later
environment.
For example, what if
the thrifty phenotype is formed but the
later environment is rich?
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Allelic variation in each of these examples
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Next topics from Chapter 7:
Aging and cancer as diseases of epigenesis
Public Health issues
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DES daughters
molecular mechanism of action: represses Hoxa10 expression
This could be called a “homeotic disruption”
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